Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NT4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | NT4 |
| Full Name | Neurotrophin 4 |
| Chromosome | 19q13.33 |
| Protein Family | Neurotrophin |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | various brain regions: - Hippocampus: CA1-CA3 regions and dentate gyrus - Cerebral cortex |
| Amino Acids | 130 aa |
| Pathways | PI3K, mTOR, mtor, MAPK |
| UniProt ID | [P34130](https://www.uniprot.org/uniprot/P34130) |
| Ensembl ID | ENSG00000100292 |
| GeneCards | NT4 |
| Human Protein Atlas | NT4 |
| Associated Diseases | neurodegeneration |
| Interactions | BDNF, MECP2, NT3, NEPRILYSIN, SIRT1, TRKB |
| KG Connections | 18 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NT4["NT4"]
Ms{"Ms"}
NT4 -->|"activates"| Ms
Als{"Als"}
NT4 -->|"activates"| Als
Alzheimer{"Alzheimer"}
NT4 -->|"activates"| Alzheimer
BDNF["BDNF"]
NT4 -->|"activates"| BDNF
MECP2["MECP2"]
NT4 -->|"activates"| MECP2
AMYLOID["AMYLOID"]
NT4 -->|"activates"| AMYLOID
NT3["NT3"]
NT4 -->|"activates"| NT3
NEPRILYSIN["NEPRILYSIN"]
NT4 -->|"activates"| NEPRILYSIN
ALZHEIMER["ALZHEIMER"]
NT4 -->|"activates"| ALZHEIMER
AND["AND"]
NT4 -->|"activates"| AND
AMYLOID_BETA["AMYLOID-BETA"]
NT4 -->|"activates"| AMYLOID_BETA
SIRT1["SIRT1"]
NT4 -->|"activates"| SIRT1
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
NT4 -->|"activates"| ALZHEIMER_S_DISEASE
TRKB["TRKB"]
NT4 -->|"activates"| TRKB
APP["APP"]
NT4 -->|"activates"| APP| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| BDNF | activates | gene | 0.60 |
| MECP2 | activates | gene | 0.60 |
| NT3 | activates | gene | 0.60 |
| NEPRILYSIN | activates | gene | 0.60 |
| SIRT1 | activates | gene | 0.60 |
| TRKB | activates | gene | 0.60 |
| APP | activates | gene | 0.60 |
| AMYLOID | activates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| AMYLOID-BETA | activates | gene | 0.60 |
| ALZHEIMER'S DISEASE | activates | gene | 0.60 |
| APP/PS1 | activates | gene | 0.60 |
| Amyloid | activates | pathway | 0.60 |
| Epigenetic | activates | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||