gene

NT4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NT4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections
0Hypotheses
0Analyses
18Outgoing
0Incoming

Summary

Page for NT4 Gene

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🧬 Gene Info
Gene SymbolNT4
Full NameNeurotrophin 4
Chromosome19q13.33
Protein FamilyNeurotrophin
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionvarious brain regions: - Hippocampus: CA1-CA3 regions and dentate gyrus - Cerebral cortex
Amino Acids130 aa
PathwaysPI3K, mTOR, mtor, MAPK
UniProt ID[P34130](https://www.uniprot.org/uniprot/P34130)
Ensembl IDENSG00000100292
GeneCardsNT4
Human Protein AtlasNT4
Associated Diseasesneurodegeneration
InteractionsBDNF, MECP2, NT3, NEPRILYSIN, SIRT1, TRKB
KG Connections18 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

NT4 Gene

gene · 1047 words

Neurotrophic Factor Therapies

therapeutic · 1747 words

NTF4 — Neurotrophin-4

gene · 769 words

Genes

index · 271 words

Pathway Diagram

graph TD
    NT4["NT4"]
    Ms{"Ms"}
    NT4 -->|"activates"| Ms
    Als{"Als"}
    NT4 -->|"activates"| Als
    Alzheimer{"Alzheimer"}
    NT4 -->|"activates"| Alzheimer
    BDNF["BDNF"]
    NT4 -->|"activates"| BDNF
    MECP2["MECP2"]
    NT4 -->|"activates"| MECP2
    AMYLOID["AMYLOID"]
    NT4 -->|"activates"| AMYLOID
    NT3["NT3"]
    NT4 -->|"activates"| NT3
    NEPRILYSIN["NEPRILYSIN"]
    NT4 -->|"activates"| NEPRILYSIN
    ALZHEIMER["ALZHEIMER"]
    NT4 -->|"activates"| ALZHEIMER
    AND["AND"]
    NT4 -->|"activates"| AND
    AMYLOID_BETA["AMYLOID-BETA"]
    NT4 -->|"activates"| AMYLOID_BETA
    SIRT1["SIRT1"]
    NT4 -->|"activates"| SIRT1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    NT4 -->|"activates"| ALZHEIMER_S_DISEASE
    TRKB["TRKB"]
    NT4 -->|"activates"| TRKB
    APP["APP"]
    NT4 -->|"activates"| APP

Outgoing (18)

TargetRelationTypeStr
Msactivatesdisease0.65
Alsactivatesdisease0.65
Alzheimeractivatesdisease0.65
BDNFactivatesgene0.60
MECP2activatesgene0.60

Incoming (0)

SourceRelationTypeStr
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found