gene 3,328 words KG: WNT4 2026-03-27
kind:genesection:genestopic:alzheimerstopic:parkinsonsstate:published
Contents

WNT4 Gene

🧬 Gene Info
Gene SymbolWNT4
Full NameWNT4
Chromosome1p36.23
Protein TypeGene
Functionis a member of the Wnt family of secreted lipid-modified signaling proteins that play critical roles in development, tissue homeostasis, and disease processes.
Primary Expressionvarious brain regions and regulates neural stem cell maintenance, neuronal differentiation, synapse formation, and neuroprotection
Amino Acids351 aa
Exons4
PathwaysWNT, Wnt, Wnt signaling
UniProt IDP56705
NCBI Gene ID7498
Ensembl IDENSG00000163359
GeneCardsWNT4
Human Protein AtlasWNT4
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsLGALS1, JAK2, GNB4, HSP90B1, EGFR, HSPA4
KG Connections28 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.44

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Wnt Signaling in Neurodegeneration
mechanism · KG edge: activates
MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: activates
QSOX1 Gene
gene · KG edge: activates
PRKACB — Protein Kinase cAMP-Activated Catalytic Subuni
gene · KG edge: activates

Knowledge Graph (12 edges)

WNT4 activates LGALS1
WNT4 activates JAK2
WNT4 regulates AKT
WNT4 activates GNB4
WNT4 regulates CANCER
WNT4 regulates Melanoma
WNT4 regulates Diabetes
WNT4 regulates Colorectal Cancer
WNT4 regulates Cancer
WNT4 activates Als