NTRK1

Understanding Entity Pages

This page aggregates everything SciDEX knows about NTRK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

NTRK1 encodes TrkA, a receptor tyrosine kinase for nerve growth factor (NGF) that mediates neuronal survival, differentiation, and synaptic plasticity. A key therapeutic target in Alzheimer's and Parkinson's disease with both agonist and antagonist strategies under investigation.

View on Wiki →

graph TD
    NTRK1["<b>NTRK1</b>"]
    BDNF["BDNF"]
    BDNF -->|"activates"| NTRK1
    LMNA["LMNA"]
    NTRK1 -->|"regulates"| LMNA
    PRDX1["PRDX1"]
    NTRK1 -->|"regulates"| PRDX1
    RNA["RNA"]
    NTRK1 -->|"regulates"| RNA
    SQSTM1["SQSTM1"]
    NTRK1 -->|"regulates"| SQSTM1
    TPM3["TPM3"]
    NTRK1 -->|"regulates"| TPM3
    NPM1["NPM1"]
    NTRK1 -->|"regulates"| NPM1
    PRDX1["PRDX1"]
    NTRK1 -->|"associated with"| PRDX1
    Genes["Genes"]
    NTRK1 -->|"causes"| Genes
    Glioma["Glioma"]
    NTRK1 -->|"causes"| Glioma
    Proteins["Proteins"]
    NTRK1 -->|"causes"| Proteins
    Genes["Genes"]
    NTRK1 -->|"interacts with"| Genes
    disease["disease"]
    NTRK1 -->|"interacts with"| disease
    disease["disease"]
    NTRK1 -->|"causes"| disease
    Neuropathy["Neuropathy"]
    NTRK1 -->|"interacts with"| Neuropathy
    Pain["Pain"]
    NTRK1 -->|"interacts with"| Pain
    arhgef2["arhgef2"]
    arhgef2 -->|"associated with"| NTRK1
    LMNA["LMNA"]
    LMNA -->|"associated with"| NTRK1
    NPM1["NPM1"]
    NPM1 -->|"associated with"| NTRK1
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"associated with"| NTRK1
    TPM3["TPM3"]
    TPM3 -->|"associated with"| NTRK1
    PDGFRA["PDGFRA"]
    PDGFRA -->|"causes"| NTRK1
    PDGFRA["PDGFRA"]
    PDGFRA -->|"activates"| NTRK1
    CCT5["CCT5"]
    CCT5 -->|"interacts with"| NTRK1
    SPTLC1["SPTLC1"]
    SPTLC1 -->|"interacts with"| NTRK1
    RAB7["RAB7"]
    RAB7 -->|"interacts with"| NTRK1
    SPTLC1["SPTLC1"]
    SPTLC1 -->|"causes"| NTRK1
    RAB7["RAB7"]
    RAB7 -->|"causes"| NTRK1