gene

TPM3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TPM3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

54Connections
0Hypotheses
0Analyses
32Outgoing
22Incoming

Summary

Comprehensive information about TPM3 (Tropomyosin 3), an actin-binding protein involved in cytoskeletal dynamics, synaptic function, and neurodegenerative diseases.

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🧬 Gene Info
Gene SymbolTPM3
Full NameTropomyosin 3
Chromosome1p36.22
Molecular Weight33 kDa
Amino Acids248 aa
Exons9
UniProt ID[P06753](https://www.uniprot.org/uniprot/P06753)
Ensembl IDENSG00000143548
GeneCardsTPM3
Human Protein AtlasTPM3
Chromosomal location1p36.22
Genomic size~11 kb
Exon count9 exons
Protein248 amino acids, ~33 kDa
TPM3.1 (γ-tropomyosin)Muscle-specific isoform
Associated DiseasesAls, Cancer, Prostate Cancer
InteractionsNPM1, LMNA, ARHGEF2, SQSTM1, PRDX1, AND
KG Connections54 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

TPM3 Gene

gene · 2465 words

TPM3 Protein — Tropomyosin 3

protein · 2046 words

ntrk1

general · 2045 words

TPM1 — Tropomyosin 1

gene · 1701 words

TPM2 — Tropomyosin 2

gene · 1363 words

TPM2 Protein — Tropomyosin 2

protein · 675 words

Pathway Diagram

graph TD
    TPM3["<b>TPM3</b>"]
    Heart_Failure{"Heart Failure"}
    TPM3 -->|"expressed in"| Heart_Failure
    Ms{"Ms"}
    TPM3 -->|"expressed in"| Ms
    TNF["TNF"]
    TPM3 -->|"expressed in"| TNF
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    TPM3 -->|"expressed in"| IMMUNE_INFILTRATION
    RIPK1["RIPK1"]
    TPM3 -->|"expressed in"| RIPK1
    TNFRSF1A["TNFRSF1A"]
    TPM3 -->|"expressed in"| TNFRSF1A
    CXCR4["CXCR4"]
    TPM3 -->|"expressed in"| CXCR4
    Necroptosis(["Necroptosis"])
    TPM3 -->|"expressed in"| Necroptosis
    neurodegeneration["neurodegeneration"]
    TPM3 -->|"implicated in"| neurodegeneration
    CD44["CD44"]
    CD44 -->|"expressed in"| TPM3
    CASP1["CASP1"]
    CASP1 -->|"expressed in"| TPM3
    MYD88["MYD88"]
    MYD88 -->|"expressed in"| TPM3
    style TPM3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (32)

TargetRelationTypeStr
Heart Failureexpressed_indisease0.65
Msexpressed_indisease0.65
Prostate Cancerassociated_withdisease0.65
Cancerassociated_withdisease0.65
Alsassociated_withdisease0.65

Incoming (22)

SourceRelationTypeStr
CD44expressed_ingene0.60
CASP1expressed_ingene0.60
MYD88expressed_ingene0.60
ARHGEF2associated_withentity0.60
LMNAassociated_withentity0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found