Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TPM3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive information about TPM3 (Tropomyosin 3), an actin-binding protein involved in cytoskeletal dynamics, synaptic function, and neurodegenerative diseases.
| Gene Symbol | TPM3 |
| Full Name | Tropomyosin 3 |
| Chromosome | 1p36.22 |
| Molecular Weight | 33 kDa |
| Amino Acids | 248 aa |
| Exons | 9 |
| UniProt ID | [P06753](https://www.uniprot.org/uniprot/P06753) |
| Ensembl ID | ENSG00000143548 |
| GeneCards | TPM3 |
| Human Protein Atlas | TPM3 |
| Chromosomal location | 1p36.22 |
| Genomic size | ~11 kb |
| Exon count | 9 exons |
| Protein | 248 amino acids, ~33 kDa |
| TPM3.1 (γ-tropomyosin) | Muscle-specific isoform |
| Associated Diseases | Als, Cancer, Prostate Cancer |
| Interactions | NPM1, LMNA, ARHGEF2, SQSTM1, PRDX1, AND |
| KG Connections | 54 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TPM3["<b>TPM3</b>"]
Heart_Failure{"Heart Failure"}
TPM3 -->|"expressed in"| Heart_Failure
Ms{"Ms"}
TPM3 -->|"expressed in"| Ms
TNF["TNF"]
TPM3 -->|"expressed in"| TNF
IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
TPM3 -->|"expressed in"| IMMUNE_INFILTRATION
RIPK1["RIPK1"]
TPM3 -->|"expressed in"| RIPK1
TNFRSF1A["TNFRSF1A"]
TPM3 -->|"expressed in"| TNFRSF1A
CXCR4["CXCR4"]
TPM3 -->|"expressed in"| CXCR4
Necroptosis(["Necroptosis"])
TPM3 -->|"expressed in"| Necroptosis
neurodegeneration["neurodegeneration"]
TPM3 -->|"implicated in"| neurodegeneration
CD44["CD44"]
CD44 -->|"expressed in"| TPM3
CASP1["CASP1"]
CASP1 -->|"expressed in"| TPM3
MYD88["MYD88"]
MYD88 -->|"expressed in"| TPM3
style TPM3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Heart Failure | expressed_in | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Prostate Cancer | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Tumor | regulates | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| TNF | expressed_in | gene | 0.60 |
| RIPK1 | expressed_in | gene | 0.60 |
| TNFRSF1A | expressed_in | gene | 0.60 |
| CXCR4 | expressed_in | gene | 0.60 |
| NPM1 | interacts_with | gene | 0.60 |
| LMNA | interacts_with | gene | 0.60 |
| ARHGEF2 | interacts_with | gene | 0.60 |
| SQSTM1 | interacts_with | gene | 0.60 |
| PRDX1 | interacts_with | gene | 0.60 |
| TPR | associated_with | gene | 0.60 |
| IMMUNE INFILTRATION | expressed_in | gene | 0.60 |
| Necroptosis | expressed_in | pathway | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| PER | associated_with | gene | 0.60 |
| RNA | regulates | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| IRF2BP2 | interacts_with | gene | 0.60 |
| T Cell | regulates | cell_type | 0.60 |
| Myosin | regulates | protein | 0.60 |
| Fus | interacts_with | protein | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| T Cell | expressed_in | cell_type | 0.55 |
| PRDX1 | associated_with | protein | 0.50 |
| NTRK1 | associated_with | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CD44 | expressed_in | gene | 0.60 |
| CASP1 | expressed_in | gene | 0.60 |
| MYD88 | expressed_in | gene | 0.60 |
| ARHGEF2 | associated_with | entity | 0.60 |
| LMNA | associated_with | entity | 0.60 |
| NPM1 | associated_with | entity | 0.60 |
| PRDX1 | associated_with | entity | 0.60 |
| SQSTM1 | associated_with | entity | 0.60 |
| PRDX1 | interacts_with | gene | 0.60 |
| ARHGEF2 | interacts_with | gene | 0.60 |
| SQSTM1 | interacts_with | gene | 0.60 |
| LMNA | interacts_with | gene | 0.60 |
| NPM1 | interacts_with | gene | 0.60 |
| NEFL | associated_with | gene | 0.60 |
| KIF5A | associated_with | gene | 0.60 |
| NTRK2 | associated_with | gene | 0.60 |
| IRF2BP2 | interacts_with | gene | 0.60 |
| IRF2BP2 | associated_with | gene | 0.60 |
| SQSTM1 | co_discussed | gene | 0.50 |
| NTRK1 | regulates | protein | 0.50 |
| RNA | regulates | gene | 0.50 |
| arhgef2 | associated_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||