protein

PRDX1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRDX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

177Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Peroxiredoxin 1: antioxidant protein with crucial roles in oxidative stress defense, redox signaling, and neuroprotection in Alzheimer's and Parkinson's disease.

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🔬 Protein Info

Gene Symbol	PRDX1
Full Name	Peroxiredoxin 1
Chromosome	1p34.2
Function	Peroxiredoxin 1 is a ubiquitous antioxidant enzyme
Molecular Weight	22 kDa
Amino Acids	199 aa
Pathways	GLYCOLYSIS
UniProt ID	Q06830
NCBI Gene ID	8852
Ensembl ID	ENSG00000117450
OMIM	176583
GeneCards	PRDX1
Human Protein Atlas	PRDX1
Approach	Mechanism
Overexpression	Gene therapy
Associated Diseases	Lymphoma, Tumor
Known Drugs/Compounds	Lipopolysaccharide, LPS
Interactions	ERK1, TRAF6, CHUK, PRDX6, MAPK14, BECN1
KG Connections	177 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (17)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PRDX1["PRDX1"] -->|"activates"| Ms["Ms"]
    PRDX1["PRDX1"] -->|"activates"| Als["Als"]
    PRDX1["PRDX1"] -->|"activates"| Cancer["Cancer"]
    PRDX1["PRDX1"] -->|"associated"| Lymphoma["Lymphoma"]
    PRDX1["PRDX1"] -->|"biomarker for"| Ms_1["Ms"]
    PRDX1["PRDX1"] -->|"associated"| Tumor["Tumor"]
    MOF["MOF"] -->|"regulates"| PRDX1["PRDX1"]
    LPS["LPS"] -.->|"inhibits"| PRDX1["PRDX1"]
    P38["P38"] -->|"activates"| PRDX1["PRDX1"]
    AKT["AKT"] -->|"activates"| PRDX1["PRDX1"]
    style PRDX1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (111)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
Redox Signaling	involved_in	process	0.95
Inflammatory Macrophage Activation	mediates	process	0.90
Redox Signaling	regulates	process	0.90
ERK1/2	phosphorylates	protein	0.85
Glycolysis	upregulates	pathway	0.85
IL-6	upregulates	protein	0.85
Glycolysis	associated_with	pathway	0.85
DLBCL	biomarker_for	disease	0.80
Als	activates	disease	0.75
Autophagy	activates	pathway	0.70
Ms	activates	disease	0.65
Cancer	activates	disease	0.65
Lymphoma	associated_with	disease	0.65
Ms	biomarker_for	disease	0.65
Tumor	associated_with	disease	0.65
ALS	activates	disease	0.65
Infection	activates	disease	0.65
Colorectal Cancer	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	regulates	disease	0.65
ALS	regulates	disease	0.65
Als	regulates	disease	0.65
HYDROGEN_PEROXIDE	regulates	protein	0.64
IL6	regulates	protein	0.64
ERK1	activates	gene	0.60
TRAF6	activates	gene	0.60
CHUK	activates	gene	0.60
PRDX6	activates	gene	0.60
MAPK14	activates	gene	0.60
BECN1	activates	gene	0.60
TNF	activates	gene	0.60
ECSIT	activates	gene	0.60
MAP3K7	activates	gene	0.60
TLR4	activates	gene	0.60
RELA	activates	gene	0.60
TAK1	activates	gene	0.60
IKBKB	activates	gene	0.60
IL6	activates	gene	0.60
LC3	activates	gene	0.60
AKT	activates	gene	0.60
P38	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
IL1B	activates	gene	0.60
CUL3	interacts_with	gene	0.60
NRF2	inhibits	gene	0.60
SQSTM1	associated_with	entity	0.60
TPM3	associated_with	entity	0.60
ARHGEF2	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60

Incoming (66)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
MOF	phosphorylates	enzyme	0.95
MOF	associated_with	enzyme	0.95
Lipopolysaccharide	modulates	compound	0.90
MOF	regulates	protein	0.72
AUTOPHAGY	activates	gene	0.70
LPS	inhibits	drug	0.64
P38	activates	gene	0.60
AKT	activates	gene	0.60
IL1B	activates	gene	0.60
ERK1	activates	gene	0.60
TLR4	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
MAPK14	activates	gene	0.60
TNF	activates	gene	0.60
MAP3K7	activates	gene	0.60
LC3	activates	gene	0.60
BECN1	activates	gene	0.60
TRAF6	activates	gene	0.60
ECSIT	activates	gene	0.60
CHUK	activates	gene	0.60
IKBKB	activates	gene	0.60
IL6	activates	gene	0.60
PRDX6	activates	gene	0.60
RELA	activates	gene	0.60
TAK1	activates	gene	0.60
MTOR	biomarker_for	gene	0.60
BRD4	biomarker_for	gene	0.60
ATM	biomarker_for	gene	0.60
PTEN	activates	gene	0.60
GPX4	activates	gene	0.60
AKT	phosphorylates	entity	0.60
ERK1	phosphorylates	entity	0.60
P38	phosphorylates	entity	0.60
ARHGEF2	associated_with	entity	0.60
LMNA	associated_with	entity	0.60
NPM1	associated_with	entity	0.60
LMNA	interacts_with	gene	0.60
NPM1	interacts_with	gene	0.60
TPM3	interacts_with	gene	0.60
ACO1	biomarker_for	gene	0.60
LPIN1	biomarker_for	gene	0.60
MT1G	biomarker_for	gene	0.60
PEBP1	biomarker_for	gene	0.60
MAP1LC3	activates	gene	0.60
CANCER	activates	gene	0.60
NF-KB	activates	gene	0.60
NFKB	activates	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
SRXN1	biomarker_for	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PRDX1

Understanding Entity Pages

Summary

Wiki Pages (17)

PRDX1 Gene

dimethyl-fumarate-nrf2-ad-nct06850597

PRDX2 — Peroxiredoxin 2

KEAP1 Protein

prdx6

PRDX1 (Peroxiredoxin 1)

FOXO3 Protein (Forkhead Box O3)

PRDX1 Protein (Peroxiredoxin 1)

ntrk1

Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2)

Oxidative Stress Therapeutics Investment Landscape

NRF2-KEAP1 Oxidative Stress Response Pathway

ARHGEF2 Gene

PRDX3 Protein

SRXN1 Protein