Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NEURONAL CELL DEATH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | NEURONAL CELL DEATH |
Knowledge base pages for this entity
graph TD
NEURONAL_CELL_DEATH["NEURONAL CELL DEATH"]
IL_6R["IL-6R"] -->|"mediates"| NEURONAL_CELL_DEATH
Beta_Amyloid["Beta-Amyloid"] -->|"causes"| NEURONAL_CELL_DEATH
Regulated_Cell_Death["Regulated Cell Death"] -->|"mediates"| NEURONAL_CELL_DEATH
Multiple_Sclerosis["Multiple Sclerosis"] -->|"causes"| NEURONAL_CELL_DEATH
Autophagy["Autophagy"] -->|"inhibits"| NEURONAL_CELL_DEATH
Inflammatory_Mediators["Inflammatory Mediators"] -->|"contributes to"| NEURONAL_CELL_DEATH
Mitochondrial_Fission["Mitochondrial Fission"] -->|"causes"| NEURONAL_CELL_DEATH
T835M["T835M"] -->|"causes"| NEURONAL_CELL_DEATH| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Neurodegenerative Diseases | associated_with | disease | 0.95 |
| IL-6R | mediates | protein | 0.93 |
| Beta-Amyloid | causes | compound | 0.90 |
| Regulated Cell Death | mediates | process | 0.90 |
| Necroptotic Signaling Pathway | mediates | pathway | 0.90 |
| Multiple Sclerosis | causes | disease | 0.90 |
| NPM | regulates | protein | 0.90 |
| Mitochondrial Fission | causes | process | 0.88 |
| Autophagy | inhibits | process | 0.88 |
| Inflammatory Mediators | contributes_to | protein | 0.88 |
| T835M | causes | protein | 0.85 |
| Chromosome Instability | contributes_to | process | 0.85 |
| DRP1 | mediates | gene | 0.85 |
| LINE-1 | mediates | process | 0.85 |
| CLU | inhibits | protein | 0.85 |
| Autophagy | regulates | process | 0.85 |
| Inflammation | causes | process | 0.85 |
| Calcium Signaling | mediates | process | 0.85 |
| Chromosome Instability | causes | process | 0.80 |
| Calcium-Dependent Processes | causes | process | 0.80 |
| Pi4Kiii Beta Inhibition | suppresses | mechanism | 0.80 |
| PARP1 | causes | gene | 0.80 |
| oxidative stress | causes | pathway | 0.80 |
| inflammation | causes | pathway | 0.80 |
| apoptosis | causes | pathway | 0.80 |
| Autophagy | involved_in | process | 0.80 |
| oxidative stress | drives | process | 0.75 |
| autophagy | protects_against | process | 0.70 |
| MAP1LC3B | protects_against | gene | 0.70 |
| NRF2 | protects_against | protein | 0.70 |
| aberrant autophagy | activates | process | 0.70 |
| ischemic stroke | causes | disease | 0.70 |
| glutamate excitotoxicity | causes | process | 0.70 |
| defective mitophagy | activates | process | 0.70 |
| TFEB | protects_against | protein | 0.70 |
| mitophagy | protects_against | process | 0.70 |
| Akt | inhibits | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||