protein

PERKPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PERKPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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Summary

Perk (Protein Kinase R Like Er Kinase) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	PERK
Full Name	perk-protein
Chromosome	2p22.2
Protein Type	Kinase
Function	Stress sensing: Accumulation of unfolded proteins in the ER lumen
Subcellular Localization	the ER membrane that activates the Integrated Stress Response (ISR) when misfolded proteins accumulate in the ER lumen (
Molecular Weight	125 kDa
UniProt ID	Search UniProt
GeneCards	PERK
Human Protein Atlas	PERK
Associated Diseases	AD, ALI, ALS, Aging, Alzheimer
Known Drugs/Compounds	rapamycin, Dolutegravir, SB202190, DTG
Interactions	MAP1LC3B, BECN1, RHOT1, STING1, LC3, MAPK8
KG Connections	878 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PERKPROTEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

perk-protein

protein · 1290 words

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Pathway Diagram

graph TD
    PERKPROTEIN["PERKPROTEIN"]
    neurodegeneration["neurodegeneration"]
    PERKPROTEIN -->|"implicated_in"| neurodegeneration
    style PERKPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found