SCN8A

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCN8A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

SCN8A is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, activates. Associated with Als, Ataxia, Migraine. Connected to 26 entities in the SciDEX knowledge graph.

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graph TD
    SCN8A["<b>SCN8A</b>"]
    Parkinson{"Parkinson"}
    SCN8A -->|"associated with"| Parkinson
    Ms{"Ms"}
    SCN8A -->|"associated with"| Ms
    Ataxia{"Ataxia"}
    SCN8A -->|"associated with"| Ataxia
    SCN8A -->|"inhibits"| Ms
    Migraine{"Migraine"}
    SCN8A -->|"inhibits"| Migraine
    AKT1["AKT1"]
    SCN8A -->|"therapeutic target"| AKT1
    SCN2A["SCN2A"]
    SCN8A -->|"therapeutic target"| SCN2A
    APOPTOSIS["APOPTOSIS"]
    SCN8A -->|"associated with"| APOPTOSIS
    SCN4A["SCN4A"]
    SCN8A -->|"therapeutic target"| SCN4A
    GBA["GBA"]
    SCN8A -->|"therapeutic target"| GBA
    Apoptosis(["Apoptosis"])
    SCN8A -->|"associated with"| Apoptosis
    Akt(["Akt"])
    SCN8A -->|"therapeutic target"| Akt
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"associated with"| SCN8A
    DOCK2["DOCK2"]
    DOCK2 -->|"associated with"| SCN8A
    TRPA1["TRPA1"]
    TRPA1 -->|"inhibits"| SCN8A
    SRC["SRC"]
    SRC -->|"inhibits"| SCN8A
    style SCN8A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0