gene

MAG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

98Connections

5Hypotheses

10Analyses

50Outgoing

41Incoming

Summary

MAG is a gene implicated in neurodegeneration research. Key relationships include: activates, contributes to, inhibits. Associated with Als, Inflammation, Multiple Sclerosis. Connected to 21 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MAG
Full Name	Myelin-Associated Glycoprotein
Chromosome	19q13.12
Protein Type	Type I membrane protein, Siglec family
Function	is a critical component of the myelin sheath in the central and peripheral nervous systems.
Pathways	Apoptosis, Oxidative Stress
UniProt ID	P20916
NCBI Gene ID	4099
Ensembl ID	ENSG00000141670
OMIM	159460
GeneCards	MAG
Human Protein Atlas	MAG
Associated Diseases	ALS, Alzheimer
Known Drugs/Compounds	aducanumab
Interactions	MIRO1, PLP1, MBP, GFAP, OLIG1, SIGLEC11
KG Connections	98 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MAG — AlphaFold P20916 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MAG["<b>MAG</b>"]
    MIRO1["MIRO1"]
    MAG -->|"inhibits"| MIRO1
    AXONAL_MITOCHONDRIAL_TRANSPORT["AXONAL MITOCHONDRIAL TRANSPORT"]
    MAG -->|"inhibits"| AXONAL_MITOCHONDRIAL_TRANSPORT
    neurodegeneration["neurodegeneration"]
    MAG -->|"implicated in"| neurodegeneration
    CNTN6["CNTN6"]
    CNTN6 -->|"upregulates"| MAG
    HDAC6["HDAC6"]
    HDAC6 -->|"inhibits"| MAG
    RHOA["RHOA"]
    RHOA -->|"activates"| MAG
    style MAG fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (57)

Target	Relation	Type	Str
oligodendrocytes	expressed_in	cell_type	0.70
Als	contributes_to	disease	0.65
Multiple Sclerosis	contributes_to	disease	0.65
Inflammation	contributes_to	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Als	inhibits	disease	0.65
MIRO1	inhibits	gene	0.60
HK1	regulates	gene	0.60
PLCB1	regulates	gene	0.60
NDUFS7	regulates	gene	0.60
CAPZB	regulates	gene	0.60
NDUFA4	regulates	gene	0.60
PLP1	inhibits	gene	0.60
MBP	inhibits	gene	0.60
GFAP	inhibits	gene	0.60
CD81	regulates	gene	0.60
OLIG1	inhibits	gene	0.60
Neural Progenitor	inhibits	cell_type	0.60
Hemoglobin	expressed_in	protein	0.60
MBP	associated_with	gene	0.60
MBP	biomarker_for	gene	0.60
SIGLEC11	interacts_with	gene	0.60
schizophrenia	interacts_with	disease	0.60
neurodegeneration	interacts_with	disease	0.60
AXONAL MITOCHONDRIAL TRANSPORT	inhibits	gene	0.60
ATP	contributes_to	gene	0.60
MICROGLIA	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
ALZHEIMER	associated_with	gene	0.60
Oligodendrocyte	inhibits	cell_type	0.60
Neuron	inhibits	cell_type	0.60
Astrocyte	inhibits	cell_type	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
Amyloid	associated_with	pathway	0.60
Myelination	inhibits	pathway	0.60
Aβ	regulates	protein	0.60
MITOCHONDRIA	regulates	gene	0.60
Raf	regulates	protein	0.60
App	associated_with	protein	0.60
Ras	inhibits	protein	0.60
App	inhibits	protein	0.60
OLIGODENDROCYTE	associated_with	gene	0.60
Alzheimer's disease	interacts_with	disease	0.60
autism spectrum disorder	interacts_with	disease	0.60
Progenitor Cell	expressed_in	cell_type	0.55
Spinal Cord	expressed_in	brain_region	0.55

Incoming (41)

Source	Relation	Type	Str
CNTN6	upregulates	gene	0.70
INFLAMMATION	activates	phenotype	0.65
HDAC6	inhibits	gene	0.60
RHOA	activates	gene	0.60
MOG	activates	gene	0.60
MBP	activates	gene	0.60
CD81	regulates	gene	0.60
GDI2	regulates	gene	0.60
OLIG1	inhibits	gene	0.60
HK1	regulates	gene	0.60
CAPZB	regulates	gene	0.60
NDUFS7	regulates	gene	0.60
NDUFA4	regulates	gene	0.60
MBP	inhibits	gene	0.60
GFAP	inhibits	gene	0.60
PLCB1	regulates	gene	0.60
PLP1	inhibits	gene	0.60
aducanumab	targets	drug	0.60
APOE4	associated_with	gene	0.60
GPR37	interacts_with	gene	0.60
BIN1	biomarker_for	gene	0.60
CD33	interacts_with	gene	0.60
APOPTOSIS	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
MYELIN	activates	gene	0.60
INFLAMMATION	contributes_to	gene	0.60
MITOCHONDRIA	contributes_to	gene	0.60
OLIGODENDROCYTE	activates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
MYELIN	inhibits	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AND	regulates	gene	0.60
GENES	inhibits	gene	0.60
ASTROCYTE	inhibits	gene	0.60
OLIGODENDROCYTE	inhibits	gene	0.60
AND	inhibits	gene	0.60
GDI2	co_expressed_with	gene	0.50
HK1	co_expressed_with	gene	0.50
ADUCANUMAB	associated_with	drug	0.45
GFAP	co_discussed	gene	0.40
ASTROCYTE	co_discussed	cell_type	0.40

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Multi-Target Hypothesis: Aβ-Induced Cholinergic Damage is Pa	0.700	-	Do β-amyloid plaques and neurofibrillary
PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Damage and Su	0.562	neurodegeneration	What upstream mechanisms trigger p53 act
Microglial TREM2 downregulation impairs damage-associated re	0.507	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Functio	0.499	neuroinflammation	Why do TAM receptors protect against neu
Magnetosonic-Triggered Transferrin Receptor Clustering	0.470	neurodegeneration	Blood-brain barrier transport mechanisms

Mentioning Analyses (10)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease. [PMID:40425446]	Sehlin D, Hultqvist G, Michno W, Aguilar	J Prev Alzheimers Dis	2025	1
Effect of ferroptosis on chronic cerebral hypoperfusion in vascular dementia. [PMID:37709116]	Fu P, Chen Y, Wu M, Bao B, Yin X, Chen Z	Exp Neurol	2023	1
On Iron Metabolism and Its Regulation. [PMID:33925597]	Vogt AS, Arsiwala T, Mohsen M, Vogel M,	Int J Mol Sci	2021	1
Transferrin Receptor Is a Specific Ferroptosis Marker. [PMID:32160546]	Feng H, Schorpp K, Jin J, Yozwiak CE, Ho	Cell Rep	2020	1
Transferrin and transferrin receptors update. [PMID:29969719]	Kawabata H	Free Radic Biol Med	2019	1
A proimmunotoxin nanodrug targeting AIDS-associated non-Hodgkin lymphoma. [PMID:41592623]	Chen S, Qi T, Peng H, Kimura E, Zhang X	J Control Release	2026	0
Time- and dose-dependent effects of bacterial infection on iron metabolism, infl [PMID:41619877]	Lu Y, Zhang Y, Niu C	Comp Biochem Physiol A Mol Int	2026	0
Ayanin combats against barium sulphate nanoparticles induced hepatotoxicity via [PMID:41666660]	Zhu D, Lu Y, Jamil S, Ashfaq H, Al-Emam	J Trace Elem Med Biol	2026	0
Role of iron and TfR1 in the application of high‑dose ascorbate against pancreat [PMID:41789665]	Piotrowsky A, Leischner C, Schmieder H,	Oncol Rep	2026	0
Brain and Liver Dual-Targeting Oridonin Nanoparticles to Enhance Aβ Clearance fo [PMID:41944296]	Gong W, Hui W, Qiao S, Ji Q, Liu M et al	Adv Sci (Weinh)	2026	0
Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in [PMID:41947413]	Palsa K, Sahu AP, Rye DB, Trotti LM, Elc	Ann Neurol	2026	0
Pulmonary neuroendocrine cell-derived exosomes regulate iron homeostasis and oxi [PMID:41950316]	Thakur A, Zhang K, Chen J, Mei S, Chen J	Sci Adv	2026	0
O-GlcNAc Modification Orchestrates HUWE1-Mediated Ubiquitination of TfR1 to Regu [PMID:41962599]	Zhang H, Li M, Zhang J, Sun Q, Jin X et	Free Radic Biol Med	2026	0
Protective Role of Polydatin Against Vancomycin-Induced Lung Toxicity via Oxidat [PMID:41963266]	Aygörmez S, Küçükler S, Çomaklı S, Şimşe	J Appl Toxicol	2026	0
Yangxin granules exert cardioprotective effects against acute myocardial infarct [PMID:41868900]	Huo G, Zhou Y, Wu Z, Sun S, Zhu G, Cheng	American journal of translatio	2026	0
Conformational dynamics study of TfR1 upon transferrin binding via NMA and MD si [PMID:41921418]	Zemmouche M, Falque G, Cadet F, Gardebie	Journal of molecular graphics	2026	0
[Effects of acupuncture on ferroptosis and ferritinophagy in cerebral ischemia-r [PMID:41839581]	Wang YF, Dong YS	Zhen ci yan jiu = Acupuncture	2026	0
The therapeutic potential of Piezo1 channel-mediated ferroptosis and its inhibit [PMID:41854751]	Nan K, Zhang L, Zhao Y, Yin S, Peng Y, H	Apoptosis : an international j	2026	0
The Role of Artemisinin and its Derivatives in Cancer Therapy via Ferroptosis: A [PMID:41833023]	Osmanlioglu Dag SR, Tatli Cankaya II, Oz	Anti-cancer agents in medicina	2026	0
The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease [PMID:41109213]	Pilat DJ, Le H, Prokopenko D, Lin CJ, Ei	Neuron	2026	0

MAG

Understanding Entity Pages

Summary

Wiki Pages (21)

MAG Gene

Section 152: Advanced Robotics and Assistive Devices in CBS/PSP

Oligodendrocyte and Myelin Dysfunction in Corticobasal Syndrome

msa-pathophysiology-disease-mechanisms

FA2H Gene

msa-oligodendrocyte-pathology

Pathway Diagram

Outgoing (57)

Incoming (41)

Targeting Hypotheses (5)

Mentioning Analyses (10)

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

What are the molecular mechanisms by which GLP-1RAs provide neuroprotective effe

Why does the V1613M variant reduce amyloid pathology when ABCA7 loss-of-function

What is the molecular mechanism by which oligodendroglial MCT1 disruption causes

What determines the specificity of DDR protein recruitment to dilncRNA-induced c

How do dilncRNAs specifically drive molecular crowding and phase separation of D

Neuroinflammation and microglial priming in early AD

Human connectome alterations and network-level dysfunction in Alzheimer disease

Digital biomarkers and AI-driven early detection of neurodegeneration

Related Papers (20)

MAG

Understanding Entity Pages

Summary

Wiki Pages (21)

MAG Gene

Section 152: Advanced Robotics and Assistive Devices in CBS/PSP

Oligodendrocyte and Myelin Dysfunction in Corticobasal Syndrome

msa-pathophysiology-disease-mechanisms

FA2H Gene

msa-oligodendrocyte-pathology

Schwann Cells in Peripheral Neuropathy

White Matter Degeneration

SPG35 Gene

Oligodendrocyte Precursor Differentiation Failure in Neurodegeneration

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

Neuroregeneration Therapies for Neurodegeneration

Myelin and White Matter Dysfunction in 4R-Tauopathies

Demyelination and Remyelination Therapies in Neurodegeneration

Nogo Protein

Multiple System Atrophy

Oligodendrocytes in Multiple System Atrophy

Disease-Associated Oligodendrocytes

LINGO1 Protein

RAC1 Protein

Oligodendroglial Involvement in Progressive Supranuclear Palsy

Pathway Diagram

Outgoing (57)

Incoming (41)

Targeting Hypotheses (5)

Mentioning Analyses (10)

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

What are the molecular mechanisms by which GLP-1RAs provide neuroprotective effe

Why does the V1613M variant reduce amyloid pathology when ABCA7 loss-of-function

What is the molecular mechanism by which oligodendroglial MCT1 disruption causes

What determines the specificity of DDR protein recruitment to dilncRNA-induced c

How do dilncRNAs specifically drive molecular crowding and phase separation of D

Neuroinflammation and microglial priming in early AD

Human connectome alterations and network-level dysfunction in Alzheimer disease

Digital biomarkers and AI-driven early detection of neurodegeneration

Related Papers (20)