gene

SCN2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCN2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections
0Hypotheses
0Analyses
24Outgoing
12Incoming

Summary

SCN2A is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, implicated in. Associated with Ataxia, Ms, Parkinson. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolSCN2A
Full NameSodium Voltage-Gated Channel Alpha Subunit 2
AliasesNav1.2 (Sodium channel voltage-gated alpha subunit 2)
Chromosome2q24.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionCerebral cortex, Hippocampus, Cerebellum
Subcellular Localizationthe axon initial segment (AIS) and nodes of Ranvier, where it plays a crucial role in action potential initiation and pr
Amino Acids2000 aa
UniProt IDO43526
NCBI Gene ID6325
Ensembl IDENSG00000136531
OMIM182390
GeneCardsSCN2A
Human Protein AtlasSCN2A
Symbol [@meisler2013] SCN2A [@rubinstein2017] [@sanders2017] Full NameSodium Voltage-Gated Channel Alpha Subunit 2
Associated DiseasesAtaxia, Ms, Parkinson, autism spectrum disorder
KG Connections36 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: SCN2A — AlphaFold O43526 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

SCN2A — Sodium Voltage-Gated Channel Alpha Subunit 2

gene · 1296 words

Ion Channel Dysfunction in Huntington's Disease

mechanism · 3782 words

ion-channel-dysfunction-disease-comparison

mechanism · 3208 words

KCNQ2 Encephalopathy

disease · 3173 words

SCN3B — Sodium Channel Beta 3 Subunit

gene · 2867 words

RNA Splicing Defects in Neurodegeneration

mechanism · 2856 words

Pathway Diagram

graph TD
    SCN2A["<b>SCN2A</b>"]
    Parkinson{"Parkinson"}
    SCN2A -->|"associated with"| Parkinson
    Ms{"Ms"}
    SCN2A -->|"associated with"| Ms
    Ataxia{"Ataxia"}
    SCN2A -->|"associated with"| Ataxia
    APOPTOSIS["APOPTOSIS"]
    SCN2A -->|"associated with"| APOPTOSIS
    SCN4A["SCN4A"]
    SCN2A -->|"therapeutic target"| SCN4A
    GBA["GBA"]
    SCN2A -->|"therapeutic target"| GBA
    Apoptosis(["Apoptosis"])
    SCN2A -->|"associated with"| Apoptosis
    Akt(["Akt"])
    SCN2A -->|"therapeutic target"| Akt
    neurodegeneration["neurodegeneration"]
    SCN2A -->|"implicated in"| neurodegeneration
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"associated with"| SCN2A
    DOCK2["DOCK2"]
    DOCK2 -->|"associated with"| SCN2A
    SCN8A["SCN8A"]
    SCN8A -->|"therapeutic target"| SCN2A
    AKT1["AKT1"]
    AKT1 -->|"therapeutic target"| SCN2A
    style SCN2A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (24)

TargetRelationTypeStr
Parkinsonassociated_withdisease0.65
Msassociated_withdisease0.65
Ataxiaassociated_withdisease0.65
SCN4Atherapeutic_targetgene0.60
GBAtherapeutic_targetgene0.60

Incoming (12)

SourceRelationTypeStr
DOCK2associated_withgene0.60
SCN8Atherapeutic_targetgene0.60
AKT1therapeutic_targetgene0.60
GBAtherapeutic_targetgene0.60
CDKL5associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found