Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SCN2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SCN2A is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, implicated in. Associated with Ataxia, Ms, Parkinson. Connected to 13 entities in the SciDEX knowledge graph.
| Gene Symbol | SCN2A |
| Full Name | Sodium Voltage-Gated Channel Alpha Subunit 2 |
| Aliases | Nav1.2 (Sodium channel voltage-gated alpha subunit 2) |
| Chromosome | 2q24.3 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | Cerebral cortex, Hippocampus, Cerebellum |
| Subcellular Localization | the axon initial segment (AIS) and nodes of Ranvier, where it plays a crucial role in action potential initiation and pr |
| Amino Acids | 2000 aa |
| UniProt ID | O43526 |
| NCBI Gene ID | 6325 |
| Ensembl ID | ENSG00000136531 |
| OMIM | 182390 |
| GeneCards | SCN2A |
| Human Protein Atlas | SCN2A |
| Symbol [@meisler2013] SCN2A [@rubinstein2017] [@sanders2017] Full Name | Sodium Voltage-Gated Channel Alpha Subunit 2 |
| Associated Diseases | Ataxia, Ms, Parkinson, autism spectrum disorder |
| KG Connections | 36 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SCN2A["<b>SCN2A</b>"]
Parkinson{"Parkinson"}
SCN2A -->|"associated with"| Parkinson
Ms{"Ms"}
SCN2A -->|"associated with"| Ms
Ataxia{"Ataxia"}
SCN2A -->|"associated with"| Ataxia
APOPTOSIS["APOPTOSIS"]
SCN2A -->|"associated with"| APOPTOSIS
SCN4A["SCN4A"]
SCN2A -->|"therapeutic target"| SCN4A
GBA["GBA"]
SCN2A -->|"therapeutic target"| GBA
Apoptosis(["Apoptosis"])
SCN2A -->|"associated with"| Apoptosis
Akt(["Akt"])
SCN2A -->|"therapeutic target"| Akt
neurodegeneration["neurodegeneration"]
SCN2A -->|"implicated in"| neurodegeneration
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"associated with"| SCN2A
DOCK2["DOCK2"]
DOCK2 -->|"associated with"| SCN2A
SCN8A["SCN8A"]
SCN8A -->|"therapeutic target"| SCN2A
AKT1["AKT1"]
AKT1 -->|"therapeutic target"| SCN2A
style SCN2A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Ataxia | associated_with | disease | 0.65 |
| SCN4A | therapeutic_target | gene | 0.60 |
| GBA | therapeutic_target | gene | 0.60 |
| AKT1 | therapeutic_target | gene | 0.60 |
| DOCK2 | associated_with | gene | 0.60 |
| SCN8A | associated_with | gene | 0.60 |
| STXBP1 | associated_with | gene | 0.60 |
| WWOX | associated_with | gene | 0.60 |
| SYNGAP1 | targets | gene | 0.60 |
| APOPTOSIS | associated_with | gene | 0.60 |
| Apoptosis | associated_with | pathway | 0.60 |
| Akt | therapeutic_target | pathway | 0.60 |
| AND | therapeutic_target | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| SYNAPSE | associated_with | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| stem cells | expressed_in | cell_type | 0.60 |
| autism spectrum disorder | causes | disease | 0.60 |
| autism spectrum disorder | associated_with | disease | 0.60 |
| microglia | expressed_in | cell_type | 0.60 |
| autism spectrum disorder | interacts_with | disease | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| DOCK2 | associated_with | gene | 0.60 |
| SCN8A | therapeutic_target | gene | 0.60 |
| AKT1 | therapeutic_target | gene | 0.60 |
| GBA | therapeutic_target | gene | 0.60 |
| CDKL5 | associated_with | gene | 0.60 |
| HCN1 | associated_with | gene | 0.60 |
| KCNQ2 | associated_with | gene | 0.60 |
| PLCB1 | associated_with | gene | 0.60 |
| SCN1A | associated_with | gene | 0.60 |
| DYRK1A | targets | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| HIPPOCAMPUS | associated_with | brain_region | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||