Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CAPZB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CAPZB is a protein involved in neurodegeneration research. Key relationships include: therapeutic target, interacts with, implicated in. Associated with Als, Ms. Connected to 11 entities in the SciDEX knowledge graph.
| Gene Symbol | CAPZB |
| Full Name | Capping Actin Protein of the Z-disc Beta |
| Chromosome | 1p36.22 |
| Function | This binding prevents the addition or loss of actin subunits at this end, functioning through several mechanisms |
| Primary Expression | the brain with specific patterns: |
| Molecular Weight | 31 kDa |
| UniProt ID | P47756 |
| NCBI Gene ID | 832 |
| Ensembl ID | ENSG00000015590 |
| OMIM | 601568 |
| GeneCards | CAPZB |
| Human Protein Atlas | CAPZB |
| Associated Diseases | ALS, Alzheimer |
| Known Drugs/Compounds | aducanumab |
| Interactions | NDUFS7, NDUFA4, Proteins, NEURODEGENERATIVE DISEASES, PLCB1, CD81 |
| KG Connections | 46 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CAPZB["<b>CAPZB</b>"]
Als{"Als"}
CAPZB -->|"therapeutic target"| Als
Ms{"Ms"}
CAPZB -->|"interacts with"| Ms
RAB5A["RAB5A"]
CAPZB -->|"therapeutic target"| RAB5A
HSPA1A["HSPA1A"]
CAPZB -->|"therapeutic target"| HSPA1A
RAB8A["RAB8A"]
CAPZB -->|"therapeutic target"| RAB8A
CANX["CANX"]
CAPZB -->|"therapeutic target"| CANX
HSPA5["HSPA5"]
CAPZB -->|"therapeutic target"| HSPA5
neurodegeneration["neurodegeneration"]
CAPZB -->|"implicated in"| neurodegeneration
RAB7A["RAB7A"]
RAB7A -->|"therapeutic target"| CAPZB
NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
NEURODEGENERATIVE_DISEASES -->|"interacts with"| CAPZB
IGF2R["IGF2R"]
IGF2R -->|"therapeutic target"| CAPZB
style CAPZB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | therapeutic_target | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| RAB5A | therapeutic_target | gene | 0.60 |
| HSPA1A | therapeutic_target | gene | 0.60 |
| RAB8A | therapeutic_target | gene | 0.60 |
| CANX | therapeutic_target | gene | 0.60 |
| HSPA5 | therapeutic_target | gene | 0.60 |
| NDUFA4 | regulates | gene | 0.60 |
| GDI2 | regulates | gene | 0.60 |
| NDUFS7 | regulates | gene | 0.60 |
| MAG | regulates | gene | 0.60 |
| PLCB1 | regulates | gene | 0.60 |
| CD81 | regulates | gene | 0.60 |
| HK1 | regulates | gene | 0.60 |
| MITOCHONDRIA | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| AMYLOID | associated_with | gene | 0.60 |
| Amyloid | associated_with | pathway | 0.60 |
| Aβ | regulates | protein | 0.60 |
| Raf | regulates | protein | 0.60 |
| App | associated_with | protein | 0.60 |
| NDUFS7 | interacts_with | gene | 0.50 |
| NDUFA4 | interacts_with | gene | 0.50 |
| CD81 | co_expressed_with | gene | 0.50 |
| GDI2 | co_expressed_with | gene | 0.50 |
| Proteins | interacts_with | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| RAB7A | therapeutic_target | gene | 0.60 |
| IGF2R | therapeutic_target | gene | 0.60 |
| CD81 | regulates | gene | 0.60 |
| GDI2 | regulates | gene | 0.60 |
| MAG | regulates | gene | 0.60 |
| HK1 | regulates | gene | 0.60 |
| PLCB1 | regulates | gene | 0.60 |
| NDUFS7 | regulates | gene | 0.60 |
| aducanumab | targets | drug | 0.60 |
| NEURODEGENERATIVE DISEASES | interacts_with | gene | 0.60 |
| MITOCHONDRIA | regulates | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| PLCB1 | interacts_with | gene | 0.50 |
| CD81 | interacts_with | gene | 0.50 |
| GDI2 | interacts_with | gene | 0.50 |
| MITOCHONDRIA | interacts_with | cell_type | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||