protein

CAPZB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CAPZB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

46Connections
0Hypotheses
0Analyses
30Outgoing
16Incoming

Summary

CAPZB is a protein involved in neurodegeneration research. Key relationships include: therapeutic target, interacts with, implicated in. Associated with Als, Ms. Connected to 11 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolCAPZB
Full NameCapping Actin Protein of the Z-disc Beta
Chromosome1p36.22
FunctionThis binding prevents the addition or loss of actin subunits at this end, functioning through several mechanisms
Primary Expressionthe brain with specific patterns:
Molecular Weight31 kDa
UniProt IDP47756
NCBI Gene ID832
Ensembl IDENSG00000015590
OMIM601568
GeneCardsCAPZB
Human Protein AtlasCAPZB
Associated DiseasesALS, Alzheimer
Known Drugs/Compoundsaducanumab
InteractionsNDUFS7, NDUFA4, Proteins, NEURODEGENERATIVE DISEASES, PLCB1, CD81
KG Connections46 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: CAPZB — AlphaFold P47756 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

CAPZB Gene

gene · 1802 words

PLCB1 Gene

gene · 1257 words

CAPZB Protein

protein · 615 words

Proteins

index · 296 words

Genes

index · 271 words

Pathway Diagram

graph TD
    CAPZB["<b>CAPZB</b>"]
    Als{"Als"}
    CAPZB -->|"therapeutic target"| Als
    Ms{"Ms"}
    CAPZB -->|"interacts with"| Ms
    RAB5A["RAB5A"]
    CAPZB -->|"therapeutic target"| RAB5A
    HSPA1A["HSPA1A"]
    CAPZB -->|"therapeutic target"| HSPA1A
    RAB8A["RAB8A"]
    CAPZB -->|"therapeutic target"| RAB8A
    CANX["CANX"]
    CAPZB -->|"therapeutic target"| CANX
    HSPA5["HSPA5"]
    CAPZB -->|"therapeutic target"| HSPA5
    neurodegeneration["neurodegeneration"]
    CAPZB -->|"implicated in"| neurodegeneration
    RAB7A["RAB7A"]
    RAB7A -->|"therapeutic target"| CAPZB
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"interacts with"| CAPZB
    IGF2R["IGF2R"]
    IGF2R -->|"therapeutic target"| CAPZB
    style CAPZB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (30)

TargetRelationTypeStr
Alstherapeutic_targetdisease0.65
Msinteracts_withdisease0.65
Alzheimerassociated_withdisease0.65
Alsassociated_withdisease0.65
ALSassociated_withdisease0.65

Incoming (16)

SourceRelationTypeStr
RAB7Atherapeutic_targetgene0.60
IGF2Rtherapeutic_targetgene0.60
CD81regulatesgene0.60
GDI2regulatesgene0.60
MAGregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found