gene

WWOX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WWOX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

54Connections
0Hypotheses
0Analyses
45Outgoing
9Incoming

Summary

WWOX is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, interacts with. Associated with Als, Alzheimer, Cancer. Connected to 46 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolWWOX
Full NameWW Domain Containing Oxidoreductase
Chromosome16q23.1
Functionencodes a tumor suppressor protein with two WW domains and a short-chain dehydrogenase/reductase (SDR) domain.
Primary Expressionthe brain, particularly in the cerebellum, cortex, and hippocampus
Amino Acids414 aa
PathwaysApoptosis, Tgf-Β
UniProt IDQ9H0M0
NCBI Gene ID54345
OMIM605515
GeneCardsWWOX
Human Protein AtlasWWOX
Associated DiseasesAlzheimer, Carcinoma
InteractionsMMP2, TAU, SMAD3, SMAD4, P38, APP
KG Connections54 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: WWOX — AlphaFold Q9H0M0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

WWOX Gene

gene · 967 words

CDKL5 Alliance

organization · 1301 words

PLCB1 Gene

gene · 1257 words

Munc18-1 Protein

protein · 1100 words

STXBP1 — Syntaxin Binding Protein 1

gene · 849 words

CDKL5

gene · 736 words

Pathway Diagram

graph TD
    WWOX["<b>WWOX</b>"]
    Carcinoma{"Carcinoma"}
    WWOX -->|"associated with"| Carcinoma
    Als{"Als"}
    WWOX -->|"expressed in"| Als
    Cancer{"Cancer"}
    WWOX -->|"regulates"| Cancer
    Tumor{"Tumor"}
    WWOX -->|"expressed in"| Tumor
    CANCER["CANCER"]
    WWOX -->|"regulates"| CANCER
    CDH1["CDH1"]
    WWOX -->|"expressed in"| CDH1
    VIM["VIM"]
    WWOX -->|"expressed in"| VIM
    MMP2["MMP2"]
    WWOX -->|"activates"| MMP2
    neurodegeneration["neurodegeneration"]
    WWOX -->|"implicated in"| neurodegeneration
    MMP9["MMP9"]
    MMP9 -->|"activates"| WWOX
    style WWOX fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (45)

TargetRelationTypeStr
Cancerinhibitsdisease0.75
CANCERinhibitsgene0.70
Carcinomaassociated_withdisease0.65
Alsexpressed_indisease0.65
Cancerregulatesdisease0.65

Incoming (9)

SourceRelationTypeStr
MMP9activatesgene0.60
CDKL5associated_withgene0.60
HCN1associated_withgene0.60
KCNQ2associated_withgene0.60
PLCB1associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found