Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about WWOX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
WWOX is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, interacts with. Associated with Als, Alzheimer, Cancer. Connected to 46 entities in the SciDEX knowledge graph.
| Gene Symbol | WWOX |
| Full Name | WW Domain Containing Oxidoreductase |
| Chromosome | 16q23.1 |
| Function | encodes a tumor suppressor protein with two WW domains and a short-chain dehydrogenase/reductase (SDR) domain. |
| Primary Expression | the brain, particularly in the cerebellum, cortex, and hippocampus |
| Amino Acids | 414 aa |
| Pathways | Apoptosis, Tgf-Β |
| UniProt ID | Q9H0M0 |
| NCBI Gene ID | 54345 |
| OMIM | 605515 |
| GeneCards | WWOX |
| Human Protein Atlas | WWOX |
| Associated Diseases | Alzheimer, Carcinoma |
| Interactions | MMP2, TAU, SMAD3, SMAD4, P38, APP |
| KG Connections | 54 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
WWOX["<b>WWOX</b>"]
Carcinoma{"Carcinoma"}
WWOX -->|"associated with"| Carcinoma
Als{"Als"}
WWOX -->|"expressed in"| Als
Cancer{"Cancer"}
WWOX -->|"regulates"| Cancer
Tumor{"Tumor"}
WWOX -->|"expressed in"| Tumor
CANCER["CANCER"]
WWOX -->|"regulates"| CANCER
CDH1["CDH1"]
WWOX -->|"expressed in"| CDH1
VIM["VIM"]
WWOX -->|"expressed in"| VIM
MMP2["MMP2"]
WWOX -->|"activates"| MMP2
neurodegeneration["neurodegeneration"]
WWOX -->|"implicated in"| neurodegeneration
MMP9["MMP9"]
MMP9 -->|"activates"| WWOX
style WWOX fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | inhibits | disease | 0.75 |
| CANCER | inhibits | gene | 0.70 |
| Carcinoma | associated_with | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| Lung Cancer | inhibits | disease | 0.65 |
| Alzheimer | inhibits | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Inflammation | inhibits | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Neurodegeneration | interacts_with | disease | 0.65 |
| VIM | expressed_in | gene | 0.60 |
| MMP2 | activates | gene | 0.60 |
| TAU | activates | gene | 0.60 |
| SMAD3 | activates | gene | 0.60 |
| SMAD4 | activates | gene | 0.60 |
| P38 | activates | gene | 0.60 |
| APP | activates | gene | 0.60 |
| TAU | inhibits | gene | 0.60 |
| JNK | interacts_with | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| CDH1 | expressed_in | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
| ALZHEIMER | inhibits | gene | 0.60 |
| P53 | inhibits | gene | 0.60 |
| AMYLOID | activates | gene | 0.60 |
| ALZHEIMER'S DISEASE | inhibits | gene | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| Immune Response | inhibits | pathway | 0.60 |
| Tgf-Β | activates | pathway | 0.60 |
| ERK | interacts_with | gene | 0.60 |
| NEURODEGENERATION | interacts_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| NF-ΚB | interacts_with | gene | 0.60 |
| P53 | activates | gene | 0.60 |
| TAU TANGLES | inhibits | gene | 0.60 |
| AMYLOID | inhibits | gene | 0.60 |
| INFLAMMATION | inhibits | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| Nf-Κb | interacts_with | pathway | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||