Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PLK4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | PLK4 |
| Full Name | Polo-Like Kinase 4 |
| Chromosome | 4q28.1 |
| Protein Type | Kinase |
| Function | is a serine/threonine protein kinase that serves as the master regulator of centriole duplication, playing a critical role in microtubule organization, ciliogenesis, and cell cycle progression. |
| Primary Expression | the central nervous system: |
| Molecular Weight | 97 kDa |
| Ensembl ID | ENSG00000142792 |
| GeneCards | PLK4 |
| Human Protein Atlas | PLK4 |
| Associated Diseases | Alzheimer, Parkinson |
| Interactions | FCGRT, KAT2A |
| KG Connections | 32 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PLK4["<b>PLK4</b>"]
Alzheimer["Alzheimer"]
PLK4 -->|"therapeutic target"| Alzheimer
Parkinson["Parkinson"]
PLK4 -->|"therapeutic target"| Parkinson
Alzheimer["Alzheimer"]
PLK4 -->|"associated with"| Alzheimer
Parkinson["Parkinson"]
PLK4 -->|"associated with"| Parkinson
FCGRT["FCGRT"]
PLK4 -->|"associated with"| FCGRT
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PLK4 -->|"associated with"| PARKINSON_S_DISEASE
PI3K["PI3K"]
PLK4 -->|"associated with"| PI3K
CASP3["CASP3"]
CASP3 -->|"therapeutic target"| PLK4
STAT3["STAT3"]
STAT3 -->|"therapeutic target"| PLK4
PARKINSON["PARKINSON"]
PARKINSON -->|"therapeutic target"| PLK4
ALZHEIMER["ALZHEIMER"]
ALZHEIMER -->|"therapeutic target"| PLK4
GENES["GENES"]
GENES -->|"associated with"| PLK4
AKT["AKT"]
AKT -->|"associated with"| PLK4
FCGRT["FCGRT"]
FCGRT -->|"associated with"| PLK4
PARKINSON["PARKINSON"]
PARKINSON -->|"associated with"| PLK4
ALZHEIMER["ALZHEIMER"]
ALZHEIMER -->|"associated with"| PLK4
STAT3["STAT3"]
STAT3 -->|"associated with"| PLK4
RAGE["RAGE"]
RAGE -->|"associated with"| PLK4
AND["AND"]
AND -->|"associated with"| PLK4
CASP3["CASP3"]
CASP3 -->|"associated with"| PLK4
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"associated with"| PLK4
neurodegeneration["neurodegeneration"]
PLK4 -->|"implicated in"| neurodegeneration| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | therapeutic_target | disease | 0.65 |
| Parkinson | therapeutic_target | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| FCGRT | associated_with | gene | 0.60 |
| PI3K | associated_with | gene | 0.60 |
| Stat3 | therapeutic_target | protein | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| Pi3K | therapeutic_target | protein | 0.60 |
| Akt | therapeutic_target | protein | 0.60 |
| App | therapeutic_target | protein | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| FCGRT | interacts_with | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CASP3 | therapeutic_target | gene | 0.60 |
| STAT3 | therapeutic_target | gene | 0.60 |
| AKT | associated_with | gene | 0.60 |
| FCGRT | associated_with | gene | 0.60 |
| STAT3 | associated_with | gene | 0.60 |
| RAGE | associated_with | gene | 0.60 |
| CASP3 | associated_with | gene | 0.60 |
| FCGRT | interacts_with | gene | 0.60 |
| KAT2A | regulates | gene | 0.60 |
| KAT2A | associated_with | gene | 0.60 |
| KAT2A | phosphorylates | gene | 0.60 |
| KAT2A | protects_against | gene | 0.60 |
| PARKINSON | therapeutic_target | gene | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||