RAGE

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAGE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Advanced Glycation End-Product Receptor gene involved in neuroinflammation

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flowchart TD
    HMGB1["HMGB1<br/>Damage-Associated<br/>Molecular Pattern"] --|"activates"|--> RAGE["RAGE<br/>Receptor for Advanced<br/>Glycation End Products"]
    
    AGEs["AGEs<br/>Advanced Glycation<br/>End Products"] --|"binds"|--> RAGE
    
    Amyloid["Amyloid-beta<br/>Peptides"] --|"binds"|--> RAGE
    
    RAGE --|"activates"|--> NF_kB["NF-kappaB<br/>Transcription Factor"]
    
    RAGE --|"activates"|--> Cathepsin_B["Cathepsin B<br/>Lysosomal Protease"]
    
    NF_kB --|"promotes"|--> Neuroinflammation["Neuroinflammation<br/>Microglial Activation"]
    
    NF_kB --|"induces"|--> Cytokines["Pro-inflammatory<br/>Cytokines<br/>(TNF-alpha, IL-1beta)"]
    
    Neuroinflammation --|"contributes_to"|--> Alzheimer["Alzheimer's Disease<br/>Neurodegeneration"]
    
    Neuroinflammation --|"contributes_to"|--> ALS["ALS<br/>Motor Neuron<br/>Degeneration"]
    
    Neuroinflammation --|"contributes_to"|--> MS["Multiple Sclerosis<br/>Demyelination"]
    
    RAGE --|"activates"|--> Oxidative_Stress["Oxidative Stress<br/>ROS Production"]
    
    Oxidative_Stress --|"damages"|--> Neurons["Neuronal Cells<br/>Synaptic Loss"]
    
    RAGE_Inhibitors["RAGE Antagonists<br/>Therapeutic Compounds"] --|"inhibits"|--> RAGE
    
    Neurons --|"leads_to"|--> Neurodegeneration["Neurodegeneration<br/>Cognitive Decline"]
    
    style RAGE fill:#006494
    style RAGE_Inhibitors fill:#1b5e20
    style Neuroinflammation fill:#ef5350
    style Oxidative_Stress fill:#ef5350
    style NF_kB fill:#4a1a6b
    style Neurodegeneration fill:#5d4400
    style Alzheimer fill:#5d4400
    style ALS fill:#5d4400
    style MS fill:#5d4400