gene

RAGE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAGE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1329Connections

5Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

Summary

Advanced Glycation End-Product Receptor gene involved in neuroinflammation

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🧬 Gene Info

Gene Symbol	RAGE
Aliases	Receptor for Advanced Glycation End Products
Protein Type	Receptor
Function	In the healthy nervous system, RAGE participates in: - Development: Neuronal differentiation and migration during embryonic development - Repair: Tissue repair and regeneration following injury - Infl
Primary Expression	hippocampus, cortex, spinal cord, Thalamus, Hypothalamus
Molecular Weight	45 kDa
Pathways	NF-κB, MAPK pathway, NF-κB signaling
GeneCards	RAGE
Human Protein Atlas	RAGE
Advanced Glycation End-products (AGEs)	Products of non-enzymatic glycation that accumulate with aging and diabetes
HMGB1	High mobility group box 1 protein released from damaged cells
S100 proteins	Calcium-binding proteins released during inflammation
Phosphatidylserine	Exposed on apoptotic cells[@bianchi2011]
[NF-κB](/entities/nf-kb) pathway	Leads to increased expression of inflammatory cytokines
MAPK pathways	Including p38, JNK, and ERK
Associated Diseases	Aging, Als, Alzheimer, Atherosclerosis, cancer
Known Drugs/Compounds	metformin, RAPAMYCIN, resveratrol, RESVERATROL
Interactions	ABCA1, ACHE, AD, ADAM10, AGER, AGING
KG Connections	1328 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

RAGE (Receptor for Advanced Glycation End Products) Signaling Pathway in Neurodegeneration

mechanism · 1032 words

→

Pathway Diagram

flowchart TD
    HMGB1["HMGB1
Damage-Associated
Molecular Pattern"] -->|"activates"| RAGE["RAGE
Receptor for Advanced
Glycation End Products"]
    
    AGEs["AGEs
Advanced Glycation
End Products"] -->|"binds"| RAGE
    
    Amyloid["Amyloid-beta
Peptides"] -->|"binds"| RAGE
    
    RAGE -->|"activates"| NF_kB["NF-kappaB
Transcription Factor"]
    
    RAGE -->|"activates"| Cathepsin_B["Cathepsin B
Lysosomal Protease"]
    
    NF_kB -->|"promotes"| Neuroinflammation["Neuroinflammation
Microglial Activation"]
    
    NF_kB -->|"induces"| Cytokines["Pro-inflammatory
Cytokines
(TNF-alpha, IL-1beta)"]
    
    Neuroinflammation -->|"contributes_to"| Alzheimer["Alzheimer's Disease
Neurodegeneration"]
    
    Neuroinflammation -->|"contributes_to"| ALS["ALS
Motor Neuron
Degeneration"]
    
    Neuroinflammation -->|"contributes_to"| MS["Multiple Sclerosis
Demyelination"]
    
    RAGE -->|"activates"| Oxidative_Stress["Oxidative Stress
ROS Production"]
    
    Oxidative_Stress -->|"damages"| Neurons["Neuronal Cells
Synaptic Loss"]
    
    RAGE_Inhibitors["RAGE Antagonists
Therapeutic Compounds"] -->|"inhibits"| RAGE
    
    Neurons -->|"leads_to"| Neurodegeneration["Neurodegeneration
Cognitive Decline"]
    
    style RAGE fill:#006494
    style RAGE_Inhibitors fill:#1b5e20
    style Neuroinflammation fill:#ef5350
    style Oxidative_Stress fill:#ef5350
    style NF_kB fill:#4a1a6b
    style Neurodegeneration fill:#5d4400
    style Alzheimer fill:#5d4400
    style ALS fill:#5d4400
    style MS fill:#5d4400

Outgoing (618)

Target	Relation	Type	Str
RAGE	encodes	protein	0.00
Inflammation	inhibits	disease	1.00
NF-κB	activates	pathway	0.87
Neuroinflammation	inhibits	disease	0.85
microglia	activates	cell_type	0.80
endothelial cells	expressed_in	cell_type	0.80
blood-brain barrier	participates_in	pathway	0.80
Aβ	binds_to	protein	0.80
cathepsin B	activates	protein	0.80
Cancer	associated_with	disease	0.75
Cancer	therapeutic_target	disease	0.75
Atherosclerosis	associated_with	disease	0.75
Als	interacts_with	disease	0.75
Inflammation	activates	disease	0.75
Alzheimer	inhibits	disease	0.75
Als	inhibits	disease	0.75
Als	activates	disease	0.75
Als	regulates	disease	0.75
STING	associated_with	gene	0.70
STING	expresses	gene	0.70
VEGF	inhibits	gene	0.70
SIRT1	activates	gene	0.70
TAU	interacts_with	gene	0.70
ULK1	activates	gene	0.70
TREM2	activates	gene	0.70
SMPD1	causes	gene	0.70
TAU	activates	gene	0.70
TAU	regulates	gene	0.70
TNF	expressed_in	gene	0.70
TAU	targets	gene	0.70
STING	enhances	gene	0.70
VEGF	regulates	gene	0.70
SOD1	expresses	gene	0.70
hippocampus	expressed_in	brain_region	0.70
neurodegeneration	associated_with	disease	0.70
INFLAMMATION	inhibits	gene	0.70
neuroinflammation	inhibits	disease	0.70
neuroinflammation	activates	disease	0.70
microglia	expressed_in	cell_type	0.70
unfolded protein response	participates_in	pathway	0.70
Mapk	therapeutic_target	pathway	0.70
Nf-Κb	activates	pathway	0.70
Oxidative Stress	inhibits	pathway	0.70
NEUROINFLAMMATION	inhibits	gene	0.70
Apoptosis	activates	pathway	0.70
diabetes	associated_with	disease	0.70
NF-kB signaling	participates_in	pathway	0.70
HMGB1	expressed_in	gene	0.70
oxidative stress response	participates_in	pathway	0.70
Senescence	activates	disease	0.65

Incoming (711)

Source	Relation	Type	Str
RAGE	encodes	gene	0.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
AGEs	binds_to	protein	0.90
HMGB1	activates	protein	0.80
PTGS2	therapeutic_target	gene	0.80
CYTOKINES	activates	gene	0.80
TNF	associated_with	gene	0.74
CASP3	associated_with	gene	0.74
GPX4	transports	gene	0.70
PERICYTE	associated_with	cell_type	0.70
PERICYTE	markers	cell_type	0.70
PERICYTES	markers	cell_type	0.70
LDLR	transports	gene	0.70
ACHE	expresses	gene	0.70
ADAM10	activates	gene	0.70
ABCA1	transports	gene	0.70
MMP2	regulates	gene	0.70
NEURONS	expressed_in	cell_type	0.70
ASTROCYTE	stabilizes	cell_type	0.70
MACROPHAGE	targets	cell_type	0.70
OLIGODENDROCYTE	biomarker_for	cell_type	0.70
GRN	disrupts	gene	0.70
ACHE	enhances	gene	0.70
ASTROCYTE	mediates	cell_type	0.70
DOPAMINERGIC	interacts_with	cell_type	0.70
CGAS	inhibits	gene	0.70
PI3K/AKT/MTOR	activates	pathway	0.70
FTD	causes	disease	0.70
AMYOTROPHIC LATERAL SCLEROSIS	activates	disease	0.70
FTD	interacts_with	disease	0.70
FRONTOTEMPORAL DEMENTIA	interacts_with	disease	0.70
CGAS	activates	gene	0.70
BIN1	interacts_with	gene	0.70
PERICYTE	activates	cell_type	0.70
ENDOTHELIAL	activates	cell_type	0.70
LAMP1	activates	gene	0.70
GASDERMIN	activates	gene	0.70
NRF2	activates	gene	0.70
CREB	activates	gene	0.70
MULTIPLE SCLEROSIS	associated_with	disease	0.70
APOE	regulates	gene	0.70
LRRK2	causes	gene	0.70
ENDOTHELIAL	expresses	cell_type	0.70
MICROGLIA	regulates	cell_type	0.70
ENDOTHELIAL	interacts_with	cell_type	0.70
NEURONS	enhances	cell_type	0.70
LRRK2	transports	gene	0.70
NLRP3	regulates	gene	0.70
BECN1	activates	gene	0.70
PDGF	activates	gene	0.70

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
S100B as Active Pathogenic BBB-Disrupting Signal via RAGE/NF	0.647	-	Blood-brain barrier permeability changes
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro	0.613	neurodegeneration	What are the mechanisms by which gut mic
RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upre	0.442	neurodegeneration	How do perivascular cells specifically r
RAGE-Mediated Transcytotic Pump Enhancement Strategy	0.380	neuropharmacology	What is the actual quantitative contribu
Astrocyte-Mediated Synaptic Tagging via CREB-S100B-RAGE Sign	0.380	synaptic-biology	What determines the selectivity of compl

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
AGE-mediated HCC induction in animal models with β-catenin signaling	validation	Hepatocellular carcinoma	0.900	0.00	animal models (species not spe	proposed	N/A

Related Papers (16)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Decoding cell death signals in liver inflammation. [PMID:23567086]	Brenner C, Galluzzi L, Kepp O, Kroemer G	J Hepatol	2013	1
Wnt-dependent modulation of alveolar epithelial phenotypes and barrier function [PMID:41678947]	Lin YC, Igarashi M, Sakai Y, Nishikawa M	Biochem Biophys Res Commun	2026	0
Luteolin targets the AGE-RAGE signaling to mitigate inflammation and ferroptosis [PMID:38917486]	Zhang N, Chen P, Liang X, Sun J, Liu Q,	Aging	2024	0
Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic li [PMID:38297127]	Fan W, Adebowale K, Váncza L, Li Y, Rabb	Nature	2024	0
Receptors for Advanced Glycation End Products (RAGE): Promising Targets Aiming a [PMID:36154605]	["Koerich S", "Parreira G", "de Almeida	Current neuropharmacology	2023	0
Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR [PMID:37442582]	Strickson S, Houslay KF, Negri VA, Ohne	The European respiratory journ	2023	0
Microglia RAGE exacerbates the progression of neurodegeneration within the SOD1 [PMID:34130712]	["MacLean M", "Juranek J", "Cuddapah S",	Journal of neuroinflammation	2021	0
Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal car [PMID:33547425]	Lieberwirth JK, Joset P, Heinze A, Hents	European journal of human gene	2021	0
Environmental Regulation, Technological Innovation, and Export Competitiveness: [PMID:32102174]	Liu J, Xie J	International journal of envir	2020	0
Predicting Subjective Recovery from Lower Limb Surgery Using Consumer Wearables. [PMID:33442582]	Karas M, Marinsek N, Goldhahn J, Foschin	Digital biomarkers	2020	0
Glycation & the RAGE axis: targeting signal transduction through DIAPH1. [PMID:27967251]	["Shekhtman A", "Ramasamy R", "Schmidt A	Expert review of proteomics	2017	0
The AGE-RAGE Axis: Implications for Age-Associated Arterial Diseases. [PMID:29259621]	["Senatus L", "Schmidt A"]	Frontiers in genetics	2017	0
Diabetes and Alzheimer's disease crosstalk. [PMID:26969101]	Baglietto-Vargas D, Shi J, Yaeger DM, Ag	Neuroscience and biobehavioral	2016	0
Pathophysiological Links Among Hypertension and Alzheimer's Disease. [PMID:26054481]	Carnevale D, Perrotta M, Lembo G, Trimar	High blood pressure & cardiova	2016	0
High-fructose intake as risk factor for neurodegeneration: Key role for carboxy [PMID:26851500]	["Mastrocola R", "Nigro D", "Cento A", "	Neurobiology of disease	2016	0
[Receptor of advanced glycation endproducts RAGE/AGER: an integrative view for c [PMID:25486663]	Barbezier N, Tessier FJ, Chango A	Annales de biologie clinique	2014	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RAGE in their description or question text

No additional research found