gene

RBM10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RBM10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

0Analyses

6Outgoing

10Incoming

Summary

RNA Binding Motif 10, an RNA-binding protein involved in alternative splicing and linked to ALS and TARP syndrome

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🧬 Gene Info

Gene Symbol	RBM10
Full Name	RNA Binding Motif 10
Aliases	RBM10, GPATCH7, SFM1, TARPS
Chromosome	Xp11.3
Function	is an RNA-binding protein that plays a critical role in the regulation of alternative splicing, a fundamental process in eukaryotic gene expression.
Primary Expression	the central nervous system and has been implicated in several neurodegenerative diseases, most notably Amyotrophic Lateral Sclerosis (ALS) and T
Molecular Weight	~130 kDa
Amino Acids	238 aa
UniProt ID	P98175
NCBI Gene ID	11198
Ensembl ID	ENSG00000139218
OMIM	300080
GeneCards	RBM10
Human Protein Atlas	RBM10
Protein Length	1,238 amino acids
Associated Diseases	Leukemia, Multiple Sclerosis, Neurodegeneration
Interactions	BCL2A1, XIAP, BCL2, APOPTOSIS, CANCER
KG Connections	16 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RBM10 — AlphaFold P98175 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RBM10["RBM10"]
    Cancer{"Cancer"}
    RBM10 -->|"inhibits"| Cancer
    Leukemia{"Leukemia"}
    RBM10 -->|"associated_with"| Leukemia
    Multiple_Sclerosis{"Multiple Sclerosis"}
    RBM10 -->|"associated_with"| Multiple_Sclerosis
    Neurodegeneration{"Neurodegeneration"}
    RBM10 -->|"implicated_in"| Neurodegeneration
    Rna_Splicing(["Rna Splicing"])
    RBM10 -->|"inhibits"| Rna_Splicing
    Apoptosis(["Apoptosis"])
    RBM10 -->|"inhibits"| Apoptosis
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"inhibits"| RBM10
    BCL2A1["BCL2A1"]
    BCL2A1 -->|"inhibits"| RBM10
    XIAP["XIAP"]
    XIAP -->|"inhibits"| RBM10
    BCL2["BCL2"]
    BCL2 -->|"inhibits"| RBM10
    CANCER["CANCER"]
    CANCER -->|"inhibits"| RBM10
    AXON["AXON"]
    AXON -->|"implicated_in"| RBM10
    TAZ["TAZ"]
    TAZ -->|"associated_with"| RBM10
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"implicated_in"| RBM10
    LAMP2["LAMP2"]
    LAMP2 -->|"associated_with"| RBM10

Outgoing (6)

Target	Relation	Type	Str
Cancer	inhibits	disease	0.65
Leukemia	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Neurodegeneration	implicated_in	disease	0.65
Rna Splicing	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60

Incoming (10)

Source	Relation	Type	Str
BCL2A1	inhibits	gene	0.60
XIAP	inhibits	gene	0.60
BCL2	inhibits	gene	0.60
TAZ	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
APOPTOSIS	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
AXON	implicated_in	gene	0.60
NEURODEGENERATION	implicated_in	gene	0.60
GENES	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

RBM10

Understanding Entity Pages

Summary

Wiki Pages (6)

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