concept

RNA SPLICING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RNA SPLICING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

130Connections

0Hypotheses

0Analyses

29Outgoing

20Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	RNA SPLICING
Key Genes/Proteins	UBIQUITIN, MYO7A, RNA, AND, GENES
Related Diseases	Retinal Degeneration, Amyotrophic Lateral Sclerosis, ALS, Frontotemporal Dementia, Dementia
Related Pathways	Mitochondrial Function
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    RNA_SPLICING["RNA SPLICING"]
    PRMT["PRMT"] -->|"regulates"| RNA_SPLICING
    TDP_43["TDP-43"] -->|"involved_in"| RNA_SPLICING
    CYTOKINES["CYTOKINES"] -->|"activates"| RNA_SPLICING
    P53["P53"] -->|"activates"| RNA_SPLICING
    IL_6["IL-6"] -->|"activates"| RNA_SPLICING
    Aging["Aging"] -->|"activates"| RNA_SPLICING
    Als["Als"] -->|"activates"| RNA_SPLICING
    Tumor["Tumor"] -->|"activates"| RNA_SPLICING
    APOPTOSIS["APOPTOSIS"] -->|"inhibits"| RNA_SPLICING

Outgoing (33)

Target	Relation	Type	Str
Retinal Degeneration	activates	disease	0.65
Amyotrophic Lateral Sclerosis	causes	disease	0.65
ALS	biomarker_for	disease	0.65
Frontotemporal Dementia	causes	disease	0.65
Dementia	causes	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
ALS	causes	disease	0.65
Aging	interacts_with	disease	0.65
UBIQUITIN	causes	protein	0.65
MYO7A	activates	gene	0.60
UBIQUITIN	associated_with	gene	0.60
RNA	associated_with	gene	0.60
AND	associated_with	gene	0.60
GENES	associated_with	gene	0.60
Mitochondrial Function	associated_with	pathway	0.60
SRRM2	causes	gene	0.60
RNA	biomarker_for	gene	0.60
AND	biomarker_for	gene	0.60
TDP-43	causes	gene	0.60
CHMP7	causes	gene	0.60
MOTOR NEURONS	interacts_with	gene	0.60
RNA	causes	gene	0.60
AND	causes	gene	0.60
Tdp-43	causes	pathway	0.60
Stem Cell	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
TDP-43	expressed_in	gene	0.55
UBIQUITIN	expressed_in	gene	0.35
TDP-43	inhibits	gene	0.35

Incoming (97)

Source	Relation	Type	Str
RNA	associated_with	gene	0.60
AND	interacts_with	gene	0.60
NRL	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	causes	gene	0.60
C9ORF72	associated_with	gene	0.60
ALS	biomarker_for	gene	0.60
DEMENTIA	causes	gene	0.60
SMN	interacts_with	gene	0.60
SMD1	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	0.60
STMN2	interacts_with	gene	0.60
NEURON	interacts_with	gene	0.60
TARDBP	implicated_in	gene	0.55
TDP-43	implicated_in	gene	0.55
AMYLOID	regulates	protein	0.35
NAFLD	associated_with	disease	0.35
ALS	associated_with	disease	0.35
FRONTOTEMPORAL DEMENTIA	associated_with	disease	0.35
ALS	causes	disease	0.35
FRONTOTEMPORAL DEMENTIA	causes	disease	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

RNA SPLICING

Understanding Entity Pages

Wiki Pages (20)

Frontotemporal Dementia (FTD) Mechanistic Pathway

Frontotemporal Dementia (FTD)

Kabuki Syndrome

ftd-tdp-pathology

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

TRA2B Protein - Transformer-2 Beta

Splice-Modulating Therapies for Neurodegeneration

TDP-43 Proteinopathy

Gemin-8 Protein

KARS1

RNA Metabolism Dysregulation in Alzheimer's Disease

TYNDASE — Tyndall

Frontotemporal Dementia

Autophagy-Lysosomal Impairment Comparison — AD/PD/ALS/FTD/HD

ALS-FTD Spectrum

TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis

4R Tau in Corticobasal Degeneration

RNA-Targeted Therapies in Neurodegeneration

ftd-tdp43-pathway