gene

RBPJL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RBPJL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections

0Hypotheses

0Analyses

27Outgoing

18Incoming

0Experiments

Summary

RBPJL encodes a transcription factor functioning in the Notch signaling pathway, with roles in pancreatic development, neuroendocrine function, synaptic plasticity, and implications for neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	RBPJL
Full Name	Recombination Binding Protein Lambda
Chromosome	20q13.12
Protein Type	Transcription Factor
Function	encodes a transcription factor that functions as a key component of the Notch signaling pathway.
Primary Expression	pancreatic islets
Pathways	Notch signaling, Notch, Notch pathway
UniProt ID	[Q9Y244](https://www.uniprot.org/uniprot/Q9Y244)
Ensembl ID	ENSG00000166323
GeneCards	RBPJL
Human Protein Atlas	RBPJL
N-terminal domain	Contains the DNA-binding motif that recognizes the consensus RBPJ binding sequence (CGTGGGAA)
Rel-homology region (RHR)	Core transcription regulatory domain
C-terminal activation/repression domain	Modulates transcriptional activity based on cellular context
Notch interaction domain	Mediates binding to Notch receptor intracellular domains
Associated Diseases	Dementia
KG Connections	45 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RBPJL["<b>RBPJL</b>"]
    Dementia{"Dementia"}
    RBPJL -->|"regulates"| Dementia
    UNC13A["UNC13A"]
    RBPJL -->|"regulates"| UNC13A
    ANO9["ANO9"]
    RBPJL -->|"biomarker for"| ANO9
    TBK1["TBK1"]
    RBPJL -->|"biomarker for"| TBK1
    Notch(["Notch"])
    RBPJL -->|"biomarker for"| Notch
    Adaptive_Immunity(["Adaptive Immunity"])
    RBPJL -->|"biomarker for"| Adaptive_Immunity
    neurodegeneration["neurodegeneration"]
    RBPJL -->|"implicated in"| neurodegeneration
    C3AR1["C3AR1"]
    C3AR1 -->|"biomarker for"| RBPJL
    GENES["GENES"]
    GENES -->|"biomarker for"| RBPJL
    DNA["DNA"]
    DNA -->|"regulates"| RBPJL
    style RBPJL fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (27)

Target	Relation	Type	Str
Dementia	regulates	disease	0.65
Dementia	implicated_in	disease	0.65
UNC13A	regulates	gene	0.60
ANO9	biomarker_for	gene	0.60
TBK1	biomarker_for	gene	0.60
C3AR1	implicated_in	gene	0.60
UNC13A	implicated_in	gene	0.60
C3AR1	biomarker_for	gene	0.60
Rb	biomarker_for	protein	0.60
TBK1	implicated_in	gene	0.60
Notch signaling	participates_in	pathway	0.60
Notch	biomarker_for	pathway	0.60
Adaptive Immunity	biomarker_for	pathway	0.60
GENES	implicated_in	gene	0.60
DNA	implicated_in	gene	0.60
DEMENTIA	implicated_in	gene	0.60
Notch	implicated_in	pathway	0.60
Adaptive Immunity	implicated_in	pathway	0.60
Neuron	regulates	cell_type	0.60
AND	biomarker_for	gene	0.60
NOTCH	biomarker_for	gene	0.60
Neuron	expressed_in	cell_type	0.55
STING	co_discussed	gene	0.50
C3AR1	associated_with	gene	0.50
VIPR1	associated_with	protein	0.50
NOTCH	associated_with	pathway	0.50
FTLD	associated_with	concept	0.50

Incoming (18)

Source	Relation	Type	Str
C3AR1	biomarker_for	gene	0.60
TBK1	implicated_in	gene	0.60
ANO9	implicated_in	gene	0.60
TBK1	biomarker_for	gene	0.60
UNC13A	regulates	gene	0.60
ANO9	biomarker_for	gene	0.60
C3AR1	implicated_in	gene	0.60
GENES	biomarker_for	gene	0.60
DNA	regulates	gene	0.60
FTLD	implicated_in	gene	0.60
NOTCH	biomarker_for	gene	0.60
FTLD	biomarker_for	gene	0.60
DEMENTIA	regulates	gene	0.60
TBK1	associated_with	gene	0.50
GENES	co_discussed	gene	0.50
NEURON	co_discussed	gene	0.50
TAR	regulates	protein	0.50
ano9	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found