Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SCN4A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SCN4A is a protein involved in neurodegeneration research. Key relationships include: associated with, therapeutic target, implicated in. Associated with Ataxia, Ms, Parkinson. Connected to 13 entities in the SciDEX knowledge graph.
| Gene Symbol | SCN4A |
| Full Name | Sodium Voltage-Gated Channel Alpha Subunit 4 |
| Aliases | Nav1.4 |
| Chromosome | 17q23.3 |
| Protein Type | Voltage-gated sodium channel (Nav channel) |
| Function | is a canonical excitability gene with well-established disease associations in periodic paralysis and nondystrophic myotonia[@cannon2018][@ptacek2000][@cannon2010]. |
| Primary Expression | skeletal muscle, research has revealed important connections to neurodegenerative diseases[@waerman2020][@finsterer2019][@van2010]: |
| Molecular Weight | 260 kDa |
| UniProt ID | Q9UQD0 (Nav1.4) |
| NCBI Gene ID | 6328 |
| Ensembl ID | ENSG00000007314 |
| GeneCards | SCN4A |
| Human Protein Atlas | SCN4A |
| Protein Class | Voltage-gated sodium channel (Nav channel) |
| Variant Type | Effect |
| Associated Diseases | Ataxia, Ms, Parkinson |
| KG Connections | 17 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SCN4A["<b>SCN4A</b>"]
Parkinson{"Parkinson"}
SCN4A -->|"associated with"| Parkinson
Ms{"Ms"}
SCN4A -->|"associated with"| Ms
Ataxia{"Ataxia"}
SCN4A -->|"associated with"| Ataxia
GBA["GBA"]
SCN4A -->|"therapeutic target"| GBA
Apoptosis(["Apoptosis"])
SCN4A -->|"associated with"| Apoptosis
Akt(["Akt"])
SCN4A -->|"therapeutic target"| Akt
neurodegeneration["neurodegeneration"]
SCN4A -->|"implicated in"| neurodegeneration
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"associated with"| SCN4A
DOCK2["DOCK2"]
DOCK2 -->|"associated with"| SCN4A
SCN8A["SCN8A"]
SCN8A -->|"therapeutic target"| SCN4A
AKT1["AKT1"]
AKT1 -->|"therapeutic target"| SCN4A
SCN2A["SCN2A"]
SCN2A -->|"therapeutic target"| SCN4A
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"associated with"| SCN4A
style SCN4A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Source | Relation | Type | Str |
|---|---|---|---|
| DOCK2 | associated_with | gene | 0.60 |
| SCN8A | therapeutic_target | gene | 0.60 |
| AKT1 | therapeutic_target | gene | 0.60 |
| SCN2A | therapeutic_target | gene | 0.60 |
| GBA | therapeutic_target | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| APOPTOSIS | associated_with | gene | 0.60 |
| AND | therapeutic_target | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| SYNAPSE | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||