protein

SCN4A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCN4A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections
0Hypotheses
0Analyses
7Outgoing
10Incoming
0Experiments

Summary

SCN4A is a protein involved in neurodegeneration research. Key relationships include: associated with, therapeutic target, implicated in. Associated with Ataxia, Ms, Parkinson. Connected to 13 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolSCN4A
Full NameSodium Voltage-Gated Channel Alpha Subunit 4
AliasesNav1.4
Chromosome17q23.3
Protein TypeVoltage-gated sodium channel (Nav channel)
Functionis a canonical excitability gene with well-established disease associations in periodic paralysis and nondystrophic myotonia[@cannon2018][@ptacek2000][@cannon2010].
Primary Expressionskeletal muscle, research has revealed important connections to neurodegenerative diseases[@waerman2020][@finsterer2019][@van2010]:
Molecular Weight260 kDa
UniProt IDQ9UQD0 (Nav1.4)
NCBI Gene ID6328
Ensembl IDENSG00000007314
GeneCardsSCN4A
Human Protein AtlasSCN4A
Protein ClassVoltage-gated sodium channel (Nav channel)
Variant TypeEffect
Associated DiseasesAtaxia, Ms, Parkinson
KG Connections17 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: SCN4A — AlphaFold Q9UQD0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

SCN4A Gene

gene · 1353 words

ion-channel-dysfunction-disease-comparison

mechanism · 3208 words

Ion Channel Dysfunction in Neurodegeneration: Cross-Disease Comparison

mechanism · 2124 words

Voltage-Gated Sodium (NaV) Channel Neurons

cell · 1998 words

CLCN1 (Chloride Voltage-Gated Channel 1)

gene · 1841 words

SCN2A — Sodium Voltage-Gated Channel Alpha Subunit 2

gene · 1296 words

Pathway Diagram

graph TD
    SCN4A["<b>SCN4A</b>"]
    Parkinson{"Parkinson"}
    SCN4A -->|"associated with"| Parkinson
    Ms{"Ms"}
    SCN4A -->|"associated with"| Ms
    Ataxia{"Ataxia"}
    SCN4A -->|"associated with"| Ataxia
    GBA["GBA"]
    SCN4A -->|"therapeutic target"| GBA
    Apoptosis(["Apoptosis"])
    SCN4A -->|"associated with"| Apoptosis
    Akt(["Akt"])
    SCN4A -->|"therapeutic target"| Akt
    neurodegeneration["neurodegeneration"]
    SCN4A -->|"implicated in"| neurodegeneration
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"associated with"| SCN4A
    DOCK2["DOCK2"]
    DOCK2 -->|"associated with"| SCN4A
    SCN8A["SCN8A"]
    SCN8A -->|"therapeutic target"| SCN4A
    AKT1["AKT1"]
    AKT1 -->|"therapeutic target"| SCN4A
    SCN2A["SCN2A"]
    SCN2A -->|"therapeutic target"| SCN4A
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"associated with"| SCN4A
    style SCN4A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (7)

TargetRelationTypeStr
Parkinsonassociated_withdisease0.65
Msassociated_withdisease0.65
Ataxiaassociated_withdisease0.65
GBAtherapeutic_targetgene0.60
DOCK2associated_withgene0.60

Incoming (10)

SourceRelationTypeStr
DOCK2associated_withgene0.60
SCN8Atherapeutic_targetgene0.60
AKT1therapeutic_targetgene0.60
SCN2Atherapeutic_targetgene0.60
GBAtherapeutic_targetgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found