gene

DOCK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DOCK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

54Connections

0Hypotheses

0Analyses

41Outgoing

13Incoming

Summary

DOCK2 (Dedicator of cytokinesis 2) is a Rac-specific guanine nucleotide exchange factor critical for immune cell migration, activation, and neuroinflammation in neurodegenerative diseases including Alzheimer's, Parkinson's, and ALS.

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🧬 Gene Info

Gene Symbol	DOCK2
Full Name	Dedicator of cytokinesis protein 2
Aliases	Dedicator of cytokinesis 2
Chromosome	5q33.3
Function	is a member of the DOCK family of guanine nucleotide exchange factors (GEFs) that specifically activates the small GTPase RAC1.
Primary Expression	hematopoietic cells, including lymphocytes, macrophages, and dendritic cells, where it plays essential roles in cell migration, adhesion, and activati
Subcellular Localization	the leading edge of migrating cells where PI3K activity is highest
Molecular Weight	215 kDa
Amino Acids	970 aa
Exons	48
UniProt ID	Q8JY91
NCBI Gene ID	1765
Ensembl ID	ENSG00000074584
OMIM	601059
GeneCards	DOCK2
Human Protein Atlas	DOCK2
Associated Diseases	Ataxia, Ms, Parkinson
Interactions	CSF1R
KG Connections	54 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DOCK2 — AlphaFold Q8JY91 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DOCK2["<b>DOCK2</b>"]
    Parkinson{"Parkinson"}
    DOCK2 -->|"associated with"| Parkinson
    Ms{"Ms"}
    DOCK2 -->|"associated with"| Ms
    Ataxia{"Ataxia"}
    DOCK2 -->|"associated with"| Ataxia
    Inflammation{"Inflammation"}
    DOCK2 -->|"therapeutic target"| Inflammation
    Senescence{"Senescence"}
    DOCK2 -->|"therapeutic target"| Senescence
    Aging{"Aging"}
    DOCK2 -->|"therapeutic target"| Aging
    DOCK2 -->|"therapeutic target"| Ms
    Autoimmune{"Autoimmune"}
    DOCK2 -->|"therapeutic target"| Autoimmune
    SCN8A["SCN8A"]
    DOCK2 -->|"associated with"| SCN8A
    AKT1["AKT1"]
    DOCK2 -->|"associated with"| AKT1
    SCN2A["SCN2A"]
    DOCK2 -->|"associated with"| SCN2A
    APOPTOSIS["APOPTOSIS"]
    DOCK2 -->|"associated with"| APOPTOSIS
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"associated with"| DOCK2
    AGING["AGING"]
    AGING -->|"therapeutic target"| DOCK2
    style DOCK2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (41)

Target	Relation	Type	Str
Parkinson	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Senescence	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
SCN8A	associated_with	gene	0.60
AKT1	associated_with	gene	0.60
SCN2A	associated_with	gene	0.60
SCN4A	associated_with	gene	0.60
GBA	associated_with	gene	0.60
CDK1	therapeutic_target	gene	0.60
PTGS2	therapeutic_target	gene	0.60
IL7R	therapeutic_target	gene	0.60
LRPPRC	associated_with	gene	0.60
HERC5	therapeutic_target	gene	0.60
UBIQUITIN	therapeutic_target	gene	0.60
RNF5	therapeutic_target	gene	0.60
MLCK	protects_against	gene	0.60
APOPTOSIS	associated_with	gene	0.60
Apoptosis	associated_with	pathway	0.60
Akt	associated_with	pathway	0.60
INFLAMMATION	therapeutic_target	gene	0.60
IMMUNE INFILTRATION	therapeutic_target	gene	0.60
IL-6	therapeutic_target	gene	0.60
Immune Response	therapeutic_target	pathway	0.60
CANCER	therapeutic_target	gene	0.60
NF-ΚB	protects_against	gene	0.60
AND	associated_with	gene	0.60
Nf-Κb	protects_against	pathway	0.60
Cortex	expressed_in	brain_region	0.55
Endothelial Cell	expressed_in	cell_type	0.55
microglia	expressed_in	cell_type	0.55
Proteins	associated_with	protein	0.50

Incoming (13)

Source	Relation	Type	Str
PINK1	associated_with	gene	0.60
GBA	associated_with	gene	0.60
SCN8A	associated_with	gene	0.60
SCN2A	associated_with	gene	0.60
AKT1	associated_with	gene	0.60
SCN4A	associated_with	gene	0.60
CSF1R	activates	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
AGING	therapeutic_target	gene	0.60
APOPTOSIS	associated_with	gene	0.60
AND	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
SYNAPSE	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DOCK2

Understanding Entity Pages

Summary

Wiki Pages (7)

DOCK2 Gene

herc5

DOCK1 Gene

RAC2 Protein

SCN4A Gene