Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TYRO3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TYRO3 Receptor Tyrosine Kinase: founding member of TAM family with critical roles in neuronal survival, synaptic function, and myelination
| Gene Symbol | TYRO3 |
| Full Name | TYRO3 - TYRO3 Receptor Tyrosine Kinase |
| Aliases | Page for TYRO3 Protein |
| Chromosome | 15q15.2 |
| Protein Type | Gene |
| Primary Expression | neurons, oligodendrocytes, and to a lesser extent in microglia, where it mediates cell survival, migration, and immune regulation through activation o |
| Molecular Weight | 140 kDa |
| Amino Acids | 903 aa |
| Exons | 22 |
| Pathways | NF-κB, PI3K, MAPK |
| UniProt ID | Q06418 |
| NCBI Gene ID | 7304 |
| Ensembl ID | ENSG00000092470 |
| GeneCards | TYRO3 |
| Human Protein Atlas | TYRO3 |
| Associated Diseases | Aging, Diabetes, Ferroptosis |
| SciDEX Hypotheses | TYRO3-STAT1 Axis to Preserve Parvalbumin Interneur |
| KG Connections | 14 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
TYRO3["TYRO3"]
TYRO3 -->|"implicated in"| neurodegeneration["neurodegeneration"]
TYRO3 ---|"associated"| Ferroptosis["Ferroptosis"]
TYRO3 ---|"associated"| Aging["Aging"]
TYRO3 ---|"associated"| Diabetes["Diabetes"]
TYRO3 ---|"associated"| SREBF1["SREBF1"]
TYRO3 ---|"associated"| CAMKK2["CAMKK2"]
FURIN["FURIN"] ---|"associated"| TYRO3
STAT3["STAT3"] ---|"associated"| TYRO3
KDM5A["KDM5A"] ---|"associated"| TYRO3
COMPLEMENT["COMPLEMENT"] ---|"associated"| TYRO3
RNA["RNA"] ---|"associated"| TYRO3| Source | Relation | Type | Str |
|---|---|---|---|
| STAT3 | associated_with | gene | 0.60 |
| KDM5A | associated_with | gene | 0.60 |
| FURIN | associated_with | gene | 0.60 |
| COMPLEMENT | associated_with | gene | 0.60 |
| RNA | associated_with | gene | 0.60 |
| FERROPTOSIS | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Functio | 0.499 | neuroinflammation | Why do TAM receptors protect against neu |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||