gene 2,468 words KG: TYRO3 2026-03-26
kind:genesection:genestopic:alzheimerstopic:parkinsonstopic:neuroinflammation
Contents

TYRO3 - TYRO3 Receptor Tyrosine Kinase

🧬 Gene Info
Gene SymbolTYRO3
Full NameTYRO3 - TYRO3 Receptor Tyrosine Kinase
AliasesPage for TYRO3 Protein
Chromosome15q15.2
Protein TypeGene
Primary Expressionneurons, oligodendrocytes, and to a lesser extent in microglia, where it mediates cell survival, migration, and immune regulation through activation o
Molecular Weight140 kDa
Amino Acids903 aa
Exons22
PathwaysNF-κB, PI3K, MAPK
UniProt IDQ06418
NCBI Gene ID7304
Ensembl IDENSG00000092470
GeneCardsTYRO3
Human Protein AtlasTYRO3
Associated DiseasesAging, Diabetes, Ferroptosis, neuroinflammation
SciDEX HypothesesTYRO3-STAT1 Axis to Preserve Parvalbumin Interneur
KG Connections18 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Functio
Score: 0.51
APOE-Dependent Autophagy Restoration
Score: 0.84
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.81
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.79
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
SREBF1 Gene
gene · KG edge: associated_with
KDM5A (Lysine Specific Demethylase 5A)
gene · KG edge: associated_with
CTSB Gene
gene · KG edge: associated_with
CDKN1A — Cyclin-Dependent Kinase Inhibitor 1A
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TYRO3 associated_with SREBF1
TYRO3 associated_with CAMKK2
TYRO3 associated_with CDKN1A
TYRO3 associated_with CTSB
TYRO3 associated_with ARNTL
TYRO3 associated_with Ferroptosis
TYRO3 associated_with Aging
TYRO3 associated_with Diabetes
TYRO3 associated_with neuroinflammation
TYRO3 involved_in tam_receptor_tyrosine_kinase_signaling

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