gene

ARNTL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ARNTL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

185Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	ARNTL
Full Name	Aryl Hydrocarbon Receptor Nuclear Translocator Like
Aliases	BMAL1, MOP9, PASD3
Chromosome	11p15.3
Protein Type	Transcription Factor
Function	Core circadian clock transcription factor
Primary Expression	Ubiquitous, highest in SCN, cortex, hippocampus
Molecular Weight	68.9 kDa
Amino Acids	626
Pathways	Circadian rhythm, CLOCK-BMAL1 pathway
UniProt ID	O00327
NCBI Gene ID	105
Ensembl ID	ENSG00000141510
OMIM	602550
GeneCards	ARNTL
Human Protein Atlas	ARNTL
Associated Diseases	ALS, Aging, Carcinoma, Diabetes, Ferroptosis, autism spectrum disorder
Interactions	LC3, CANCER, FERROPTOSIS, AND, MITOCHONDRIAL DNA, MTDNA
KG Connections	185 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ARNTL — AlphaFold O00327 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ARNTL["ARNTL"] -->|"associated"| Autophagy["Autophagy"]
    style Autophagy fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#e0e0e0
    ARNTL["ARNTL"] -->|"regulates"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ARNTL["ARNTL"] -->|"regulates"| Metabolic_Syndrome["Metabolic Syndrome"]
    style Metabolic_Syndrome fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ARNTL["ARNTL"] -->|"regulates"| Obesity["Obesity"]
    style Obesity fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ARNTL["ARNTL"] -->|"regulates"| Atherosclerosis["Atherosclerosis"]
    style Atherosclerosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ARNTL["ARNTL"] -->|"regulates"| Diabetes["Diabetes"]
    style Diabetes fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ARNTL["ARNTL"] -->|"activates"| Cancer["Cancer"]
    style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    AUTOPHAGY["AUTOPHAGY"] -->|"associated"| ARNTL["ARNTL"]
    style AUTOPHAGY fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    BMAL1["BMAL1"] -->|"regulates"| ARNTL["ARNTL"]
    style BMAL1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    CLOCK["CLOCK"] -->|"regulates"| ARNTL["ARNTL"]
    style CLOCK fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    MAP1LC3B["MAP1LC3B"] -->|"associated"| ARNTL["ARNTL"]
    style MAP1LC3B fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    GPX4["GPX4"] -->|"associated"| ARNTL["ARNTL"]
    style GPX4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style ARNTL fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (124)

Target	Relation	Type	Str
Autophagy	associated_with	pathway	0.70
Sleep Disorder	expressed_in	disease	0.65
Als	regulates	disease	0.65
Metabolic Syndrome	regulates	disease	0.65
Obesity	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Cancer	activates	disease	0.65
Carcinoma	associated_with	disease	0.65
Als	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Ms	contributes_to	disease	0.65
Cancer	contributes_to	disease	0.65
Tumor	contributes_to	disease	0.65
ALS	regulates	disease	0.65
ALS	activates	disease	0.65
Aging	inhibits	disease	0.65
Senescence	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Autism	expressed_in	disease	0.65
Ferroptosis	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
CGAS	associated_with	gene	0.60
SLC7A11	associated_with	gene	0.60
TMEM173	associated_with	gene	0.60
FANCD2	associated_with	gene	0.60
STING1	associated_with	gene	0.60
TFAM	associated_with	gene	0.60
POLG	associated_with	gene	0.60
ATM	associated_with	gene	0.60
NCOA4	associated_with	gene	0.60
LC3	associated_with	gene	0.60
BMAL1	regulates	gene	0.60
CLOCK	regulates	gene	0.60
BMAL1	associated_with	gene	0.60
CLOCK	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
ATM	activates	entity	0.60
BMAL1	activates	entity	0.60
CGAS	activates	entity	0.60
FANCD2	activates	entity	0.60
GPX4	activates	entity	0.60
MAP1LC3B	activates	entity	0.60
NCOA4	activates	entity	0.60
POLG	activates	entity	0.60
SLC7A11	activates	entity	0.60
STING1	activates	entity	0.60

Incoming (61)

Source	Relation	Type	Str
h-828b3729	targets_gene	hypothesis	0.90
AUTOPHAGY	associated_with	gene	0.70
BMAL1	regulates	gene	0.60
CLOCK	regulates	gene	0.60
MAP1LC3B	associated_with	gene	0.60
GPX4	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
NCOA4	associated_with	gene	0.60
ATM	associated_with	gene	0.60
CGAS	associated_with	gene	0.60
TMEM173	associated_with	gene	0.60
SLC7A11	associated_with	gene	0.60
POLG	associated_with	gene	0.60
STING1	associated_with	gene	0.60
CLOCK	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
BMAL1	inhibits	gene	0.60
NFKBIA	expressed_in	gene	0.60
NPAS2	expressed_in	gene	0.60
MTNR1A	expressed_in	gene	0.60
PER2	expressed_in	gene	0.60
PER3	expressed_in	gene	0.60
PER1	expressed_in	gene	0.60
NR1D1	expressed_in	gene	0.60
MTNR1B	expressed_in	gene	0.60
CLOCK	expressed_in	gene	0.60
STAT3	associated_with	gene	0.60
KDM5A	associated_with	gene	0.60
TYRO3	associated_with	gene	0.60
SREBF1	associated_with	gene	0.60
CAMKK2	associated_with	gene	0.60
CDKN1A	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
FANCD2	associated_with	gene	0.60
ARNT	regulates	gene	0.60
GENES	regulates	gene	0.60
MITOCHONDRIAL DNA	associated_with	gene	0.60
ALOX	associated_with	gene	0.60
ATG	associated_with	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
CANCER	contributes_to	gene	0.60
ROS	associated_with	gene	0.60
DNA	associated_with	gene	0.60
CANCER	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
MTDNA	associated_with	gene	0.60
AND	contributes_to	gene	0.60
AND	expressed_in	gene	0.60
CIRCADIAN RHYTHM	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Neuroinflammation and microglial priming in early Alzheimer's Disease

neurodegeneration | 2026-04-04 | 14 hypotheses Top: 0.508

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ARNTL

Understanding Entity Pages

Wiki Pages (21)

ARNTL Gene — Aryl Hydrocarbon Receptor Nuclear Translocator Like (BMAL1)

Circadian Rhythm in Neurodegeneration

Circadian Dysfunction Across Neurodegenerative Diseases

Circadian Rhythm Dysfunction in Corticobasal Syndrome

GNB4 Protein — G Protein Subunit Beta 4

TYRO3 - TYRO3 Receptor Tyrosine Kinase

Circadian Rhythm Dysfunction in Alzheimer's Disease

Glymphatic-Circadian Axis Dysfunction Hypothesis in Parkinson's Disease

RORγ Protein

RORB Gene

ARNT2 - Aryl Hydrocarbon Receptor Nuclear Translocator 2

Circadian-Glymphatic-Metabolic Coupling Failure Hypothesis in AD

GNB4 Gene — G Protein Subunit Beta 4

NR1D2 (Nuclear Receptor Subfamily 1 Group D Member 2)

CSNK1D Protein (Casein Kinase 1 Delta)

Circadian Rhythm Dysfunction in 4R-Tauopathies

Suprachiasmatic Nucleus Neurons in Circadian Disorders

Exercise as Treatment of Fatigue in Parkinson's Disease (NCT06324422)

CSNK1E - Casein Kinase 1 Epsilon

REV-ERBβ Protein