gene

ARNTL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ARNTL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

186Connections

2Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

4Debates

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🧬 Gene Info

Gene Symbol	ARNTL
Full Name	Aryl Hydrocarbon Receptor Nuclear Translocator Like
Aliases	BMAL1, MOP3
Chromosome	11p15.3
Protein Type	Transcription Factor
Function	Core circadian clock transcription factor
Primary Expression	Ubiquitous, highest in SCN, cortex, hippocampus
Molecular Weight	68.9 kDa
Amino Acids	626
Pathways	Circadian rhythm, CLOCK-BMAL1 pathway
UniProt ID	O00327
NCBI Gene ID	105
Ensembl ID	ENSG00000133794
OMIM	602550
GeneCards	ARNTL
Human Protein Atlas	ARNTL
Associated Diseases	Aging, ALS, autism spectrum disorder, Carcinoma, Diabetes, Ferroptosis
Interactions	AGING, ALOX, AND, ATG, BMAL1, CANCER
SciDEX Hypotheses	Microglial-Specific Circadian Gene Therapy BMAL1-CLOCK regulation of miR-143/145 locks microg
KG Connections	186 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ARNTL — AlphaFold O00327 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ARNTL Gene — Aryl Hydrocarbon Receptor Nuclear Translocator Like (BMAL1)

gene · 2535 words

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BMAL1 (ARNTL) Gene

gene · 641 words

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Pathway Diagram

graph TD
    ARNTL["ARNTL"] -->|"associated"| Autophagy["Autophagy"]
    style Autophagy fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#e0e0e0
    ARNTL["ARNTL"] -->|"regulates"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ARNTL["ARNTL"] -->|"regulates"| Metabolic_Syndrome["Metabolic Syndrome"]
    style Metabolic_Syndrome fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ARNTL["ARNTL"] -->|"regulates"| Obesity["Obesity"]
    style Obesity fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ARNTL["ARNTL"] -->|"regulates"| Atherosclerosis["Atherosclerosis"]
    style Atherosclerosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ARNTL["ARNTL"] -->|"regulates"| Diabetes["Diabetes"]
    style Diabetes fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ARNTL["ARNTL"] -->|"activates"| Cancer["Cancer"]
    style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    AUTOPHAGY["AUTOPHAGY"] -->|"associated"| ARNTL["ARNTL"]
    style AUTOPHAGY fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    BMAL1["BMAL1"] -->|"regulates"| ARNTL["ARNTL"]
    style BMAL1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    CLOCK["CLOCK"] -->|"regulates"| ARNTL["ARNTL"]
    style CLOCK fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    MAP1LC3B["MAP1LC3B"] -->|"associated"| ARNTL["ARNTL"]
    style MAP1LC3B fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    GPX4["GPX4"] -->|"associated"| ARNTL["ARNTL"]
    style GPX4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style ARNTL fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (127)

Target	Relation	Type	Str
NLRP3	transcriptionally_regulates	gene	0.90
NLRP3	associated_with	gene	0.70
circadian rhythm	regulates	phenotype	0.70
inflammatory_gene_expression	regulates	mechanism	0.70
Inflammatory gene expression	regulates	phenotype	0.70
NLRP3	regulates	gene	0.70
Autophagy	associated_with	pathway	0.70
Tumor	contributes_to	disease	0.65
Metabolic Syndrome	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Sleep Disorder	expressed_in	disease	0.65
Autism	expressed_in	disease	0.65
ALS	regulates	disease	0.65
Als	activates	disease	0.65
Als	expressed_in	disease	0.65
Diabetes	associated_with	disease	0.65
ALS	activates	disease	0.65
Cancer	contributes_to	disease	0.65
Als	regulates	disease	0.65
Aging	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
Aging	inhibits	disease	0.65
Carcinoma	associated_with	disease	0.65
Cancer	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Ferroptosis	associated_with	disease	0.65
Senescence	expressed_in	disease	0.65
Atherosclerosis	regulates	disease	0.65
Ms	contributes_to	disease	0.65
Cancer	therapeutic_target	disease	0.65
Obesity	regulates	disease	0.65
MTNR1A	expressed_in	gene	0.60
PER3	expressed_in	gene	0.60
SQSTM1	associated_with	gene	0.60
GPX4	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
CLOCK	associated_with	gene	0.60
POLG	associated_with	gene	0.60
TMEM173	activates	entity	0.60
TFAM	activates	entity	0.60
BMAL1	associated_with	gene	0.60
CLOCK	regulates	gene	0.60
ferroptosis	participates_in	pathway	0.60
SLC7A11	activates	entity	0.60
TFAM	associated_with	gene	0.60
TMEM173	associated_with	gene	0.60
LC3	activates	gene	0.60
thalamus	expressed_in	brain_region	0.60
STING1	activates	entity	0.60
Rb	expressed_in	protein	0.60

Incoming (59)

Source	Relation	Type	Str
h-828b3729	targets	hypothesis	0.90
AUTOPHAGY	associated_with	gene	0.70
MITOCHONDRIAL DNA	associated_with	gene	0.60
ALOX	associated_with	gene	0.60
ATG	associated_with	gene	0.60
MTDNA	associated_with	gene	0.60
ALOX	activates	gene	0.60
GENES	regulates	gene	0.60
AND	activates	gene	0.60
SLC7A11	associated_with	gene	0.60
POLG	associated_with	gene	0.60
STING1	associated_with	gene	0.60
CLOCK	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
ROS	associated_with	gene	0.60
DNA	associated_with	gene	0.60
CANCER	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
NPAS2	expressed_in	gene	0.60
MTNR1A	expressed_in	gene	0.60
PER2	expressed_in	gene	0.60
PER3	expressed_in	gene	0.60
PER1	expressed_in	gene	0.60
NR1D1	expressed_in	gene	0.60
MTNR1B	expressed_in	gene	0.60
CLOCK	expressed_in	gene	0.60
NF-ΚB	expressed_in	gene	0.60
AGING	inhibits	gene	0.60
GENES	expressed_in	gene	0.60
FURIN	associated_with	gene	0.60
COMPLEMENT	associated_with	gene	0.60
RNA	associated_with	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
FANCD2	associated_with	gene	0.60
ARNT	regulates	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
CANCER	contributes_to	gene	0.60
AND	contributes_to	gene	0.60
CLOCK	regulates	gene	0.60
MAP1LC3B	associated_with	gene	0.60
GPX4	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
NCOA4	associated_with	gene	0.60
ATM	associated_with	gene	0.60
CGAS	associated_with	gene	0.60
TMEM173	associated_with	gene	0.60
BMAL1	inhibits	gene	0.60
NFKBIA	expressed_in	gene	0.60
STAT3	associated_with	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Microglial-Specific Circadian Gene Therapy	0.455	chronobiology	Can circadian interventions reverse micr
BMAL1-CLOCK regulation of miR-143/145 locks microglia into g	0.389	neuroinflammation	Do microglia actually switch between gly