Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about USP18: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | OTULIN |
| Full Name | OTU Deubiquitinase with Linear Linkage Specificity |
| Chromosome | 5p15.2 |
| Protein Type | Protease |
| Function | Unlike other OTU family members, OTULIN shows exceptional specificity for linear ubiquitin chains and does not efficiently cleave other ubiquitin linkage types. |
| Pathways | NF-κB signaling, NF-κB Signaling, NF-κB |
| Ensembl ID | ENSG00000135547 |
| GeneCards | OTULIN |
| Human Protein Atlas | OTULIN |
| Alzheimer's Disease | OTULIN regulates tau expression through linear ubiquitin-dependent mechanisms. Dysregulation of OTULIN may contribute to tau pathology in AD. [@ref] |
| Parkinson's Disease | Implicated in PD pathogenesis through regulation of protein quality control pathways |
| Amyotrophic Lateral Sclerosis (ALS) | Rare variants may modify ALS risk through effects on proteostasis |
| Immunodeficiency | Loss-of-function mutations cause OTULIN-related immunodeficiency and inflammatory disease |
| Cancer | Altered expression in various cancers, affecting cell proliferation and survival |
| Associated Diseases | Infection, Inflammation |
| Interactions | IKBKG, TNF, UBIQUITIN, NFKB, NF-ΚB, MITOCHONDRIA |
| KG Connections | 39 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
USP18["<b>USP18</b>"]
Als{"Als"}
USP18 -->|"associated with"| Als
Ms{"Ms"}
USP18 -->|"associated with"| Ms
Depression{"Depression"}
USP18 -->|"associated with"| Depression
Inflammation{"Inflammation"}
USP18 -->|"associated with"| Inflammation
CXCL12["CXCL12"]
USP18 -->|"associated with"| CXCL12
neurodegeneration["neurodegeneration"]
USP18 -->|"implicated in"| neurodegeneration
SGK1["SGK1"]
SGK1 -->|"associated with"| USP18
FKBP5["FKBP5"]
FKBP5 -->|"associated with"| USP18
A2M["A2M"]
A2M -->|"associated with"| USP18
AQP4["AQP4"]
AQP4 -->|"associated with"| USP18
TNF["TNF"]
TNF -->|"associated with"| USP18
P2RX7["P2RX7"]
P2RX7 -->|"associated with"| USP18
ISG15["ISG15"]
ISG15 -->|"associated with"| USP18
STAT1["STAT1"]
STAT1 -->|"associated with"| USP18
style USP18 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Depression | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| CXCL12 | associated_with | gene | 0.60 |
| benchmark_ot_ad_answer_key:USP18 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| SGK1 | associated_with | gene | 0.60 |
| FKBP5 | associated_with | gene | 0.60 |
| A2M | associated_with | gene | 0.60 |
| AQP4 | associated_with | gene | 0.60 |
| TNF | associated_with | gene | 0.60 |
| P2RX7 | associated_with | gene | 0.60 |
| ISG15 | associated_with | gene | 0.60 |
| STAT1 | associated_with | gene | 0.60 |
| benchmark_ot_ad_answer_key:USP18 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||