concept

USP22

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about USP22: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections

0Hypotheses

0Analyses

22Outgoing

14Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	USP22
Key Genes/Proteins	NLRP3, HIF1A, MYH9, ATG5, CASP1
Related Diseases	hepatocellular carcinoma, Alum-Induced Peritonitis, Lipopolysaccharide-Induced Systemic Inflammation

Wiki Pages (7)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    USP22["USP22"]
    USP22 -->|"inhibits"| NLRP3["NLRP3"]
    USP22 -->|"inhibits"| NLRP3_Inflammasome_Activation["NLRP3 Inflammasome Activation"]
    USP22 -->|"inhibits"| NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"]
    USP22 -->|"deubiquitinates"| HIF1A["HIF1A"]
    USP22 -->|"regulates"| UBIQUITIN["UBIQUITIN"]
    USP22 -->|"target for"| hepatocellular_carcinoma["hepatocellular carcinoma"]
    MYH9["MYH9"] -->|"interacts"| USP22

Outgoing (22)

Target	Relation	Type	Str
NLRP3	inhibits	protein	0.95
NLRP3 Inflammasome Activation	inhibits	process	0.95
HIF1A	deubiquitinates	protein	0.95
NLRP3	downregulates	protein	0.90
ATG5	associated_with	protein	0.90
UBIQUITIN	regulates	entity	0.90
hepatocellular carcinoma	therapeutic_target	disease	0.88
CASP1	inhibits	protein	0.85
Alum-Induced Peritonitis	protects_against	disease	0.85
Lipopolysaccharide-Induced Systemic Inflammation	protects_against	disease	0.85
ATG5	downregulates	gene	0.85
K27-linked ubiquitination	downregulates	process	0.85
K48-linked ubiquitination	downregulates	process	0.85
systemic inflammation	inhibits	phenotype	0.85
AUTOPHAGY	promotes	process	0.80
peritonitis	protects_against	disease	0.80
NLRP3 inflammasome-related diseases	therapeutic_target	disease	0.80
ATG5	interacts_with	gene	0.70
pyroptosis	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60

Incoming (14)

Source	Relation	Type	Str
MYH9	interacts_with	protein	0.92
NLRP3	degraded_by	protein	0.90
NLRP3	activates	gene	0.60
ATG5	activates	gene	0.60
ATG5	implicated_in	gene	0.60
ASC	activates	gene	0.60
ATP	activates	gene	0.60
CASP1	activates	gene	0.60
IL18	activates	gene	0.60
IL1B	activates	gene	0.60
NLR	activates	gene	0.60
NLRC4	activates	gene	0.60
PYCARD	activates	gene	0.60
TNF	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

USP22

Understanding Entity Pages

Wiki Pages (7)

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NLRP3 Inflammasome