gene

PYCARD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PYCARD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

711Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

PYCARD is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, regulates. Associated with ALS, Aging, Als. Connected to 218 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	PYCARD
Protein Family	PYD/CARD adaptor family
Protein Type	Signaling Protein
Target Class	Signaling Protein
Function	PYCARD functions as the central adaptor in inflammasome signaling.
Mechanism of Action	PYCARD acts as a critical adaptor protein in inflammasome activation, facilitating pro-inflammatory caspase-1 recruitment and subsequent IL-1β/IL-18 processing, which contributes to neuroinflammatory processes in neurodegenerative conditions like Alzheimer's and Parkinson's disease. Its protein-protein interaction domains mediate inflammatory signal transduction, potentially amplifying neuronal damage through excessive immune response activation.
Subcellular Localization	Cytoplasm (inflammasome specks)
Druggability	Low (0.35)
Clinical Stage	Phase II
Molecular Weight	22 kDa
Amino Acids	90 aa
Pathways	Apoptosis, Inflammasome, Inflammatory response, PANoptosis, Pyroptosis
UniProt ID	Q9ULZ3
GeneCards	PYCARD
Human Protein Atlas	PYCARD
Associated Diseases	ALS, Aging, Alzheimer, Alzheimer's disease, Atherosclerosis, COPD
Known Drugs/Compounds	rapamycin
Interactions	NLRP3, CASP1, IL1B, BECN1, SNCA, AIF1
SciDEX Target	View Target Profile (1 clinical trials)
KG Connections	711 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PYCARD — AlphaFold Q9ULZ3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PYCARD["PYCARD"]
    PYCARD -->|"interacts"| NLRP3["NLRP3"]
    PYCARD -->|"interacts"| CASP1["CASP1"]
    PYCARD -->|"interacts"| IL1B["IL1B"]
    PYCARD -->|"inhibits"| Neurodegeneration["Neurodegeneration"]
    PYCARD -->|"inhibits"| Inflammation["Inflammation"]
    PYCARD -->|"inhibits"| Als["Als"]
    PYCARD -->|"inhibits"| Aging["Aging"]
    PYCARD -->|"regulates"| Tumor["Tumor"]
    PYCARD -->|"regulates"| Parkinson["Parkinson"]
    PYCARD -->|"activates"| Ms["Ms"]
    h_e7e1f943["h-e7e1f943"] -->|"target for"| PYCARD
    NLRP3 -->|"interacts"| PYCARD
    CASP1 -->|"interacts"| PYCARD
    IL1B -->|"interacts"| PYCARD
    ACTB["ACTB"] -->|"inhibits"| PYCARD
    IL6["IL6"] -->|"regulates"| PYCARD
    ATG5["ATG5"] -->|"inhibits"| PYCARD
    GFAP["GFAP"] -->|"inhibits"| PYCARD

Outgoing (425)

Target	Relation	Type	Str
Parkinson'S Disease	biomarker_for	disease	0.88
Tumor	associated_with	disease	0.85
Inflammation	activates	disease	0.85
NLRP3 inflammasome activation	involved_in	process	0.80
pyroptosis	participates_in	pathway	0.80
oxidative stress response	participates_in	pathway	0.80
autophagy pathway	participates_in	pathway	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
Nlrp3 Inflammasome	involved_in	process	0.80
TNF	associated_with	gene	0.80
IL1B	associated_with	gene	0.70
CASP1	associated_with	gene	0.70
NOD2	associated_with	gene	0.70
IBD	associated_with	disease	0.70
Inflammasome	inhibits	pathway	0.70
Autophagy	inhibits	pathway	0.70
Autophagy	associated_with	pathway	0.70
Inflammasome	activates	pathway	0.70
AUTOPHAGY	associated_with	gene	0.70
macrophages	expressed_in	cell_type	0.70
neurodegeneration	associated_with	disease	0.65
NLRP3	interacts_with	gene	0.65
CASP1	interacts_with	gene	0.65
IL1B	interacts_with	gene	0.65
RIPK3	activates	gene	0.65
SQSTM1	activates	gene	0.65
STAT3	activates	gene	0.65
TNF	activates	gene	0.65
ULK1	activates	gene	0.65
Neurodegeneration	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Als	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Tumor	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Ms	associated_with	disease	0.65
Ms	activates	disease	0.65
Parkinson	inhibits	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
ALS	inhibits	disease	0.65
Melanoma	associated_with	disease	0.65
Infection	activates	disease	0.65
Bacterial Infection	activates	disease	0.65
Colorectal Cancer	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Inflammatory Bowel Disease	associated_with	disease	0.65
TUMOR	activates	disease	0.65
Pyroptosis	associated_with	disease	0.65

Incoming (286)

Source	Relation	Type	Str
NLRP3	co_mentioned_with	gene	0.90
h-e7e1f943	targets_gene	hypothesis	0.90
h-var-6957745fea	targets_gene	hypothesis	0.90
h-var-08a4d5c07a	targets_gene	hypothesis	0.90
h-var-d04a952932	targets_gene	hypothesis	0.90
h-var-adfecef68a	targets_gene	hypothesis	0.90
h-var-af9eb8e59b	targets_gene	hypothesis	0.90
h-var-a0933e666d	targets_gene	hypothesis	0.90
ASC	associated_with	gene	0.80
NLRP3	associated_with	gene	0.80
INFLAMMATION	activates	gene	0.80
AIM2	associated_with	gene	0.70
LAMP1	associated_with	gene	0.70
SQSTM1	associated_with	gene	0.70
ULK1	associated_with	gene	0.70
LC3	associated_with	gene	0.70
ASC	activates	gene	0.70
IL1B	co_mentioned_with	gene	0.70
AUTOPHAGY	inhibits	gene	0.70
rapamycin	targets	drug	0.70
NLR	activates	gene	0.70
NLRP3	interacts_with	gene	0.65
CASP1	interacts_with	gene	0.65
IL1B	interacts_with	gene	0.65
BECN1	activates	gene	0.65
LC3	activates	gene	0.65
MTOR	interacts_with	gene	0.65
CANCER	activates	disease	0.65
DENDRITIC CELL	activates	cell_type	0.65
MAPK	activates	gene	0.65
CASP1	co_mentioned_with	gene	0.60
ACTB	inhibits	gene	0.60
IL1B	inhibits	gene	0.60
IL6	regulates	gene	0.60
CASP1	inhibits	gene	0.60
ATG5	inhibits	gene	0.60
GFAP	inhibits	gene	0.60
SNCA	inhibits	gene	0.60
BECN1	inhibits	gene	0.60
AIF1	inhibits	gene	0.60
ATG7	inhibits	gene	0.60
ASC	regulates	gene	0.60
NLRP3	inhibits	gene	0.60
GAPDH	inhibits	gene	0.60
SQSTM1	regulates	gene	0.60
TNF	regulates	gene	0.60
IL1B	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
NLRC4	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.617

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PYCARD

Understanding Entity Pages

Summary

Wiki Pages (21)

PYCARD Gene

cbs-psp-daily-action-plan

CBS/PSP Supplements Guide

neuroinflammation

coq10-neurodegeneration

omega-3-fatty-acids-neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

Sulforaphane and Nrf2 Activation for Neuroprotection

Coenzyme Q10 for Neurodegeneration

deferiprone-neurodegeneration

vitamin-d-therapy-neurodegeneration

Neuroprotection Strategies in Neurodegeneration

Curcumin for Neurodegeneration

Mediterranean and MIND Diets for Neurodegeneration

creatine-supplementation-neurodegeneration

Ambroxol for Neurodegeneration (GCase Chaperone Strategy)

NAD+ Precursors for Neurodegeneration

Creatine for Neuroprotection

tudca-udca-neurodegeneration

alpha-lipoic-acid-neurodegeneration