Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about VITAMIN D: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | VITAMIN D |
| Key Genes/Proteins | AMPK, INFLAMMASOME |
| Related Diseases | FIBROSIS, MULTIPLE SCLEROSIS, STROKE, ISCHEMIA |
Knowledge base pages for this entity
graph TD
VITAMIN_D["VITAMIN D"]
VITAMIN_D -->|"binds"| VDR["VDR"]
VITAMIN_D -.protects against.-> Diabetic_Nephropathy["Diabetic Nephropathy"]
VITAMIN_D -->|"involved_in"| Brain_Function["Brain Function"]
VITAMIN_D -->|"suppresses"| Nlrp3_Inflammasome["Nlrp3 Inflammasome"]
VITAMIN_D -->|"modulates"| Dopamine_Neurons["Dopamine Neurons"]
FERROPTOSIS["FERROPTOSIS"] -->|"inhibits"| VITAMIN_D
AUTOPHAGY["AUTOPHAGY"] -->|"activates"| VITAMIN_D
AMPK["AMPK"] -->|"activates"| VITAMIN_D
INFLAMMATION["INFLAMMATION"] -->|"inhibits"| VITAMIN_D
FIBROSIS["FIBROSIS"] -->|"inhibits"| VITAMIN_D
MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"] -.protects against.-> VITAMIN_D
INFLAMMASOME["INFLAMMASOME"] -->|"activates"| VITAMIN_D
NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"regulates"| VITAMIN_D| Target | Relation | Type | Str |
|---|---|---|---|
| Diabetic Nephropathy | protects_against | disease | 0.85 |
| Brain Function | involved_in | process | 0.85 |
| Nlrp3 Inflammasome | suppresses | pathway | 0.80 |
| Dopamine Neurons | modulates | cell_type | 0.75 |
| KL | modulates | gene | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's Disease | associated_with | disease | 0.70 |
| Parkinson's Disease | associated_with | disease | 0.70 |
| Multiple Sclerosis | associated_with | disease | 0.70 |
| Vascular Dementia | associated_with | disease | 0.70 |
| FERROPTOSIS | inhibits | process | 0.35 |
| AUTOPHAGY | activates | process | 0.35 |
| AMPK | activates | gene | 0.35 |
| INFLAMMATION | inhibits | process | 0.35 |
| FIBROSIS | inhibits | disease | 0.35 |
| MULTIPLE SCLEROSIS | protects_against | disease | 0.35 |
| INFLAMMASOME | activates | protein | 0.35 |
| NEUROINFLAMMATION | regulates | process | 0.35 |
| MACROPHAGES | regulates | cell_type | 0.35 |
| MICROGLIA | regulates | cell_type | 0.35 |
| STROKE | regulates | disease | 0.35 |
| STROKE | interacts_with | disease | 0.35 |
| ISCHEMIA | regulates | disease | 0.35 |
| MACROPHAGES | activates | cell_type | 0.35 |
| MICROGLIA | activates | cell_type | 0.35 |
| ISCHEMIA | activates | disease | 0.35 |
| HYPOTHALAMUS | activates | brain_region | 0.35 |
| SENESCENCE | activates | process | 0.35 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity