biological_process

INFLAMMASOME

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INFLAMMASOME: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1710Connections

6Hypotheses

1Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🧬 Biological Process Info

Name	INFLAMMASOME
Key Genes/Proteins	IL-18, CASP1, TNF, UBIQUITIN, NF-KB
Related Diseases	M1 Polarization, Multiple Sclerosis, Alzheimer's Disease, Parkinson's Disease, ALZHEIMER'S DISEASE
Linked Hypotheses	7 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    INFLAMMASOME["Inflammasome"]
    NLRP3["NLRP3"]
    PYCARD["PYCARD/ASC"]
    MICROGLIA["Microglia"]
    INFLAMMATION["Inflammation"]
    TNF["TNF-alpha"]
    IL1B["IL-1beta"]
    NEURODEGENERATION["Neurodegeneration"]
    PARKINSON["Parkinson's Disease"]
    MULTIPLE_SCLEROSIS["Multiple Sclerosis"]
    SNCA["alpha-synuclein (SNCA)"]
    PARKIN["Parkin"]
    AUTOPHAGY["Autophagy"]
    UBIQUITIN["Ubiquitin System"]

    NLRP3 -->|"forms"| INFLAMMASOME
    PYCARD -->|"assembles"| INFLAMMASOME
    INFLAMMASOME -->|"activates"| MICROGLIA
    INFLAMMASOME -->|"triggers"| INFLAMMATION
    INFLAMMASOME -->|"releases"| TNF
    INFLAMMASOME -->|"releases"| IL1B
    INFLAMMATION -->|"promotes"| NEURODEGENERATION
    MICROGLIA -->|"amplifies"| INFLAMMATION
    SNCA -->|"activates"| INFLAMMASOME
    NEURODEGENERATION -->|"leads to"| PARKINSON
    NEURODEGENERATION -->|"contributes to"| MULTIPLE_SCLEROSIS
    INFLAMMASOME -->|"impairs"| AUTOPHAGY
    PARKIN -->|"regulates"| AUTOPHAGY
    AUTOPHAGY -->|"clears"| SNCA
    INFLAMMASOME -->|"activates"| UBIQUITIN

    style INFLAMMASOME fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style AUTOPHAGY fill:#1b5e20,stroke:#333,stroke-width:2px
    style PARKIN fill:#1b5e20,stroke:#333,stroke-width:2px
    style NEURODEGENERATION fill:#ef5350,stroke:#333,stroke-width:2px
    style INFLAMMATION fill:#ef5350,stroke:#333,stroke-width:2px
    style PARKINSON fill:#7d4200,stroke:#333,stroke-width:2px
    style MULTIPLE_SCLEROSIS fill:#7d4200,stroke:#333,stroke-width:2px
    style NLRP3 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style SNCA fill:#4a1a6b,stroke:#333,stroke-width:2px
    style TNF fill:#4a1a6b,stroke:#333,stroke-width:2px

Outgoing (245)

Target	Relation	Type	Str
Metabolic Reprogramming	causes	process	0.90
M1 Polarization	causes	phenotype	0.88
MICROGLIA	interacts_with	cell_type	0.86
AUTOPHAGY	activates	process	0.86
Multiple Sclerosis	involved_in	disease	0.85
Alzheimer's Disease	involved_in	disease	0.85
Parkinson's Disease	involved_in	disease	0.85
NEUROINFLAMMATION	associated_with	process	0.58
ALZHEIMER'S DISEASE	associated_with	disease	0.58
TNF	interacts_with	gene	0.58
UBIQUITIN	interacts_with	gene	0.58
NF-KB	activates	gene	0.58
AUTOPHAGY	associated_with	process	0.58
MICROGLIA	co_discussed	entity	0.50
NEURODEGENERATION	co_discussed	entity	0.50
NLRP3	co_discussed	entity	0.50
ISCHEMIA	co_discussed	entity	0.50
MITOCHONDRIA	co_discussed	entity	0.50
NEUROINFLAMMATION	co_discussed	entity	0.50
MULTIPLE SCLEROSIS	co_discussed	entity	0.50
PARKINSON	co_discussed	entity	0.50
PARKINSON'S	co_discussed	entity	0.50
PYROPTOSIS	co_discussed	entity	0.50
PARKINSON	contributes_to	entity	0.50
PYCARD	co_discussed	entity	0.50
TREM2	co_discussed	entity	0.50
NEURON	co_discussed	entity	0.50
MITOPHAGY	co_discussed	entity	0.50
MACROPHAGE	co_discussed	entity	0.50
MACROPHAGES	co_discussed	entity	0.50
ASTROCYTES	activates	cell_type	0.44
NEURODEGENERATION	associated_with	process	0.44
CYTOKINES	activates	protein	0.44
ALZHEIMER'S DISEASE	activates	disease	0.44
PARKINSON'S DISEASE	activates	disease	0.44
INFLAMMATION	inhibits	process	0.44
AUTOPHAGY	degrades	process	0.44
NEURON	interacts_with	cell_type	0.44
MULTIPLE SCLEROSIS	regulates	disease	0.35
TREM2	regulates	gene	0.35
NEURON	biomarker_for	cell_type	0.35
LYMPHOMA	interacts_with	disease	0.35
TAU	causes	protein	0.35
SQSTM1	regulates	gene	0.35
P62	regulates	gene	0.35
LRRK2	interacts_with	gene	0.35
LRRK2	activates	gene	0.35
TRAUMATIC BRAIN INJURY	interacts_with	disease	0.35
OBESITY	causes	disease	0.35
MACROPHAGES	causes	cell_type	0.35

Incoming (1465)

Source	Relation	Type	Str
MICROGLIA	interacts_with	cell_type	0.86
IL-18	regulates	gene	0.65
CASP1	regulates	gene	0.65
COMPLEMENT	co_discussed	entity	0.50
ASTROCYTE	co_discussed	entity	0.50
ASTROCYTES	co_discussed	entity	0.50
CYTOKINE	co_discussed	entity	0.50
ALZHEIMER	co_discussed	entity	0.50
ALZHEIMER'S	co_discussed	entity	0.50
CASP1	co_discussed	entity	0.50
IL1B	co_discussed	entity	0.50
AUTOPHAGY	co_discussed	entity	0.50
ATG5	co_discussed	entity	0.50
DOPAMINERGIC	co_discussed	entity	0.50
AMPK	co_discussed	entity	0.50
IL-18	activates	gene	0.50
CASP1	interacts_with	gene	0.50
ENDOTHELIAL CELLS	activates	cell_type	0.50
DOPAMINERGIC NEURONS	activates	cell_type	0.50
HIPPOCAMPUS	activates	brain_region	0.50
AMPK	interacts_with	gene	0.44
COMPLEMENT	protects_against	protein	0.35
DEPRESSION	implicated_in	disease	0.35
ER STRESS	activates	process	0.35
CANCER	interacts_with	disease	0.35
CASP1	expressed_in	gene	0.35
ASTROCYTES	biomarker_for	cell_type	0.35
GSH	activates	gene	0.35
DEPRESSION	interacts_with	disease	0.35
CASP3	interacts_with	gene	0.35
BCL2	interacts_with	gene	0.35
BDNF	interacts_with	gene	0.35
BAX	interacts_with	gene	0.35
ATG7	activates	gene	0.35
ALPHA-SYNUCLEIN	inhibits	gene	0.35
AMYLOID-BETA	activates	protein	0.35
IMMUNE RESPONSE	interacts_with	process	0.35
ALZHEIMER'S DISEASE	biomarker_for	disease	0.35
COMPLEMENT ACTIVATION	activates	process	0.35
ANXIETY	regulates	disease	0.35
IBA1	regulates	gene	0.35
FRONTOTEMPORAL DEMENTIA	associated_with	disease	0.35
B CELLS	interacts_with	cell_type	0.35
HIPPOCAMPUS	interacts_with	brain_region	0.35
DOPAMINERGIC NEURONS	inhibits	cell_type	0.35
CHOLESTEROL METABOLISM	activates	process	0.35
IL-10	regulates	gene	0.35
CEREBRAL CORTEX	activates	brain_region	0.35
CORTEX	regulates	brain_region	0.35
DOPAMINERGIC NEURONS	regulates	cell_type	0.35

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Microglial AIM2 Inflammasome as the Primary Driver of TDP-43	0.601	neurodegeneration	What are the mechanisms by which gut mic
Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S	0.599	neurodegeneration	What are the mechanisms by which gut mic
Microbial Inflammasome Priming Prevention	0.584	neurodegeneration	What are the mechanisms by which gut mic
Mitochondrial DAMPs-Driven AIM2 Inflammasome Activation in N	0.582	neurodegeneration	What are the mechanisms by which gut mic
Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re	0.581	neurodegeneration	What are the mechanisms by which gut mic

Mitochondrial DNA-Driven AIM2 Inflammasome Activation in Neu	0.580	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (1)

Scientific analyses that reference this entity

Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression

neuroscience | 2026-04-04 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Systemic inflammation as a central player in the initiation and development of A [PMID:40841660]	Bayraktaroglu I, Ortí-Casañ N, Van Dam D	Immunity & ageing : I & A	2025	1
USP22 suppresses the NLRP3 inflammasome by degrading NLRP3 via ATG5-dependent au [PMID:35900990]	["Di Q", "Zhao X", "Tang H", "Li X", "Xi	Autophagy	2023	1
USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradatio [PMID:34486483]	["Cai B", "Zhao J", "Zhang Y", "Liu Y",	Autophagy	2022	1
Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861]	["Han X", "Sun S", "Sun Y", "Song Q", "Z	Autophagy	2020	1
Interweaving microglial senescence and gut microbiome dynamics in Alzheimer's di [PMID:41747877]	Waghmare A, Rahangdale S, Khare K, Taksa	Molecular and cellular neurosc	2026	0
The Immuno-Glial Connectome in Alzheimer's Disease: Integrating Central and Peri [PMID:41569436]	Gopalakrishna PK, Che Mohd Nassir CMN, A	Cellular and molecular neurobi	2026	0
Elevated expression of the NLRP3 inflammasome in post-mortem brain white matter [PMID:41687275]	Otálora-Alcaraz A, Sun MC, Hofman N, Cos	Multiple sclerosis and related	2026	0
NLRP3 Inflammasome and Polycystic Ovary Syndrome (PCOS): A Novel Profile in Adip [PMID:41596350]	Alenezi SA, Alshammari K, Khan R, Amer S	International journal of molec	2026	0
Exploring the Role of Microglial Cells in the Gut-Brain Axis Communication: A Sy [PMID:40662222]	Ortiz-Samur NS, Vijaya AK, Burokas A, Me	Journal of neurochemistry	2025	0
Sepsis and the Liver. [PMID:41439929]	["Geladari E", "Kalergi A", "Evangelopou	Diseases (Basel, Switzerland)	2025	0
Molecular links between inflammatory bowel disease and Alzheimer's disease throu [PMID:41480321]	Durairajan SSK, Singh AK, Sulaiman SM, P	World journal of gastroenterol	2025	0
Bone marrow vacuolization to curative strategies: Evolving paradigms in VEXAS sy [PMID:40784090]	["Elbadry M", "Mabed M"]	Current research in translatio	2025	0
Δ9-Tetrahydrocannabinol and cannabidiol selectively suppress toll-like receptor [PMID:40553974]	Sermet S, Finn BM, Crawford RB, Kaminski	The Journal of pharmacology an	2025	0
Nlrc4 Inflammasome Expression After Acute Myocardial Infarction in Rats. [PMID:40332346]	Borim PA, Gatto M, Mota GAF, Meirelles A	International journal of molec	2025	0
The NLRP3-inflammasome inhibitor MCC950 improves cardiac function in a HFpEF mou [PMID:39616735]	["Li S", "Withaar C", "Rodrigues P", "Zi	Biomedicine & pharmacotherapy	2024	0
Andrographolide Attenuates NLRP3 Inflammasome Activation and Airway Inflammation [PMID:38808326]	Yu Y, Miao TW, Xiao W, Mao B, Du LY, Wan	Drug design, development and t	2024	0
GSK872 and necrostatin-1 protect retinal ganglion cells against necroptosis thro [PMID:36289519]	["Liu M", "Li H", "Yang R", "Ji D", "Xia	Journal of neuroinflammation	2022	0
T cell-oriented strategies for controlling the COVID-19 pandemic. [PMID:34497383]	["Noh J", "Jeong H", "Kim J", "Shin E"]	Nature reviews. Immunology	2021	0
Norethisterone and its acetate - what's so special about them? [PMID:32398290]	Huvinen E, Holopainen E, Heikinheimo O	BMJ sexual & reproductive heal	2021	0
Potential application value of PET/computed tomography in retroperitoneal leiomy [PMID:33741860]	["Gao Y", "Yang Z", "Yu J", "Li N", "Wan	Nuclear medicine communication	2021	0

INFLAMMASOME

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Corticobasal Syndrome (CBS)

Novel Therapy Index

CBS/PSP Supplements Guide

Atypical Parkinsonism

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

Alzheimer's Disease Mechanism Index

Therapeutics

neuroinflammation

NRF2 Oxidative Stress Pathway

Alzheimer's Disease

Microglial Cells — Cell Type Hierarchy

coq10-neurodegeneration

NTF4 Protein

TREM2 Mechanism Hub

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

GSK-3β in Neurodegeneration

Mitochondrial Dysfunction in Parkinson's Disease