disease

FIBROSIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FIBROSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2398Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	FOXO1, SLC7A11, GPX4, PPARGC1A, PINK1, STROKE, PPAR, PIEZO2
Therapeutic Agents	SORAFENIB
KG Connections	455 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    FIBROSIS["FIBROSIS"] -->|"activates"| SLC7A11["SLC7A11"]
    style SLC7A11 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    FIBROSIS["FIBROSIS"] -->|"regulates"| BCL2["BCL2"]
    style BCL2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    FIBROSIS["FIBROSIS"] -->|"regulates"| COLORECTAL_CANCER["COLORECTAL CANCER"]
    style COLORECTAL_CANCER fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    FIBROSIS["FIBROSIS"] -->|"activates"| EGFR["EGFR"]
    style EGFR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    FIBROSIS["FIBROSIS"] -->|"regulates"| CGAS["CGAS"]
    style CGAS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    FIBROSIS["FIBROSIS"] -->|"activates"| FOXO1["FOXO1"]
    style FOXO1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    FIBROSIS["FIBROSIS"] -->|"activates"| MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    style MITOCHONDRIAL_DYSFUNCTION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    STEATOHEPATITIS["STEATOHEPATITIS"] -->|"activates"| FIBROSIS["FIBROSIS"]
    style STEATOHEPATITIS fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    FERROPTOSIS["FERROPTOSIS"] -->|"regulates"| FIBROSIS["FIBROSIS"]
    style FERROPTOSIS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    BECN1["BECN1"] -->|"interacts"| FIBROSIS["FIBROSIS"]
    style BECN1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    FOXO1_1["FOXO1"] -->|"protects against"| FIBROSIS["FIBROSIS"]
    style FOXO1_1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    AKT["AKT"] -->|"regulates"| FIBROSIS["FIBROSIS"]
    style AKT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style FIBROSIS fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (781)

Target	Relation	Type	Str
MACROPHAGES	activates	cell_type	0.95
MACROPHAGES	regulates	cell_type	0.65
HEPATOCYTES	activates	cell_type	0.65
MACROPHAGE	targets	cell_type	0.65
IGF1	regulates	gene	0.65
PI3K/AKT/MTOR	inhibits	pathway	0.65
MACROPHAGE	produces	cell_type	0.65
MACROPHAGE	treats	cell_type	0.65
DEXAMETHASONE	inhibits	drug	0.65
BRD4	targets	gene	0.65
FIBROGENESIS	interacts_with	phenotype	0.65
MACROPHAGES	associated_with	cell_type	0.50
MACROPHAGES	causes	cell_type	0.50
SENESCENCE	interacts_with	process	0.50
STEM CELLS	regulates	cell_type	0.50
NAFLD	activates	disease	0.50
BCL-2	activates	protein	0.50
HSPG2	activates	concept	0.50
INSULIN	activates	concept	0.50
FIBROBLASTS	activates	concept	0.50
CDH1	activates	concept	0.50
Epithelial Cell	activates	cell_type	0.50
disease	activates	disease	0.50
AKT1S1	activates	concept	0.50
Crohn Disease	activates	disease	0.50
Cystic Fibrosis	activates	disease	0.50
Macrophage	activates	cell_type	0.50
Macrophage	inhibits	cell_type	0.50
ferroptosis	associated_with	phenotype	0.50
disease	associated_with	disease	0.50
Nephropathy	associated_with	disease	0.50
CARCINOMA	activates	disease	0.50
ferroptosis	activates	phenotype	0.50
Lupus	activates	disease	0.50
Nephropathy	activates	disease	0.50
Renal Cell Carcinoma	activates	disease	0.50
ferroptosis	regulates	phenotype	0.50
disease	regulates	disease	0.50
NATURAL COMPOUNDS	regulates	concept	0.50
Cardiac	causes	disease	0.50
Cholesterol	inhibits	pathway	0.50
Insulin Resistance	inhibits	disease	0.50
INSULIN	inhibits	concept	0.50
DIABETES	activates	disease	0.50
Hepatitis	activates	disease	0.50
OBESITY	activates	disease	0.50
Infection	activates	disease	0.50
Fatty Liver	activates	disease	0.50
GENE EXPRESSION	activates	concept	0.50
Chronic Kidney Disease	associated_with	disease	0.50

Incoming (1617)

Source	Relation	Type	Str
FIBROBLASTS	activates	cell_type	0.95
HEPATITIS	interacts_with	disease	0.65
METFORMIN	interacts_with	drug	0.65
SQSTM1	treats	gene	0.65
SNAP25	inhibits	gene	0.65
SNAP25	regulates	gene	0.65
SENESCENCE	targets	phenotype	0.65
NLRP3 INFLAMMASOME	causes	pathway	0.65
SORAFENIB	treats	drug	0.65
SNCA	exacerbates	gene	0.65
SNCA	causes	gene	0.65
HK2	inhibits	gene	0.65
MYELOID CELLS	causes	cell_type	0.65
MYELOID CELLS	activates	cell_type	0.65
TH	inhibits	gene	0.65
TH	activates	gene	0.65
APIGENIN	inhibits	drug	0.65
BRD4	inhibits	gene	0.65
BRD4	treats	gene	0.65
SIRT3	treats	gene	0.65
SEMAGLUTIDE	inhibits	drug	0.65
MMP2	interacts_with	gene	0.65
STEATOHEPATITIS	activates	disease	0.64
SNAP25	depleted_in	gene	0.55
CANCER	expressed_in	disease	0.55
TH	implicated_in	gene	0.55
ATHEROSCLEROSIS	regulates	disease	0.50
FIBROBLASTS	regulates	cell_type	0.50
DAG1	activates	gene	0.50
IGF1R	activates	gene	0.50
DYSTROGLYCAN	activates	protein	0.50
AMBRA1	activates	protein	0.50
AKT1	activates	gene	0.50
ATG16L1	activates	gene	0.50
Autophagy	activates	process	0.50
CGAS	activates	protein	0.50
BECN1	activates	gene	0.50
CFTR	activates	gene	0.50
CALCOCO2	activates	gene	0.50
AMPK	activates	protein	0.50
PIEZO1	activates	gene	0.50
PIEZO1	regulates	gene	0.50
PIEZO1	inhibits	gene	0.50
inflammation	inhibits	pathway	0.50
inflammation	activates	pathway	0.50
FOXO1	activates	gene	0.50
TGF-Β1	activates	protein	0.50
FOXO1	regulates	gene	0.50
CCL4	regulates	gene	0.50
FOXO1	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FIBROSIS

Understanding Entity Pages

Wiki Pages (20)

Niemann-Pick Disease Type C (NPC)

Spinal Cord Stimulation-Affected Neurons

JPH2 — Junctophilin 2

Longevity and Rejuvenation Therapies Landscape

GPT - Alanine Transaminase (ALT)

Choroid-Plexus-in-Alzheimers-Disease

SERPINA3 Gene — Alpha-1 Antichymotrypsin in Neurodegeneration

Liver-Brain Neurodegeneration Axis

Nurr1 (NR4A2) Pathway in Parkinson's Disease

Friedreich's Ataxia

Senolytic Therapies for CBS and [PSP](/diseases/progressive-supranuclear-palsy)

TAZ (WWTR1)

Safety and Clinical Outcomes Study: Amniotic and Umbilical Cord Tissue Admini... (NCT03899298)

fabry-disease

TMEM175 Protein

PLAU Gene (Urokinase)

TERT Gene

HRG2010 for Parkinson's Disease With Motor Fluctuations (NCT06596876)