Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ZDHHC8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | ZDHHC8 |
| Full Name | Zinc Finger DHHC-Type Palmitoyltransferase 8 |
| Chromosome | 22q11.21 |
| Protein Type | Enzyme |
| Function | is a critical enzyme that catalyzes S-acylation (palmitoylation) of proteins, a reversible post-translational modification essential for protein trafficking, localization, and function in neurons. |
| Primary Expression | Brain (Cortex, Hippocampus, Cerebellum), Neurons |
| Pathways | Ferroptosis |
| UniProt ID | Q9NXK5 |
| NCBI Gene ID | 57103 |
| Ensembl ID | ENSG00000140995 |
| OMIM | 611415 |
| GeneCards | ZDHHC8 |
| Human Protein Atlas | ZDHHC8 |
| Associated Diseases | Cancer, ferroptosis |
| Known Drugs/Compounds | PF-670462 |
| Interactions | CD8, GPX4, FERROPTOSIS, CANCER, NEURODEGENERATION, AND |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ZDHHC8["<b>ZDHHC8</b>"]
GPX4["GPX4"]
ZDHHC8 -->|"modifies"| GPX4
ferroptosis["ferroptosis"]
ZDHHC8 -->|"inhibits"| ferroptosis
Aging{"Aging"}
ZDHHC8 -->|"inhibits"| Aging
Neurodegeneration{"Neurodegeneration"}
ZDHHC8 -->|"inhibits"| Neurodegeneration
Cancer{"Cancer"}
ZDHHC8 -->|"inhibits"| Cancer
Ischemia{"Ischemia"}
ZDHHC8 -->|"inhibits"| Ischemia
Ms{"Ms"}
ZDHHC8 -->|"inhibits"| Ms
Tumor{"Tumor"}
ZDHHC8 -->|"expressed in"| Tumor
CD8["CD8"]
ZDHHC8 -->|"inhibits"| CD8
FERROPTOSIS["FERROPTOSIS"]
ZDHHC8 -->|"activates"| FERROPTOSIS
CANCER["CANCER"]
ZDHHC8 -->|"inhibits"| CANCER
ZDHHC8 -->|"activates"| GPX4
PF_670462["PF-670462"]
PF_670462 -->|"inhibits"| ZDHHC8
AGING["AGING"]
AGING -->|"inhibits"| ZDHHC8
NEURODEGENERATION["NEURODEGENERATION"]
NEURODEGENERATION -->|"inhibits"| ZDHHC8
style ZDHHC8 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| GPX4 | modifies | protein | 0.90 |
| Cancer | associated_with | disease | 0.85 |
| ferroptosis | inhibits | phenotype | 0.80 |
| GPX4 | palmitoylates | protein | 0.80 |
| Aging | inhibits | disease | 0.65 |
| Neurodegeneration | inhibits | disease | 0.65 |
| Cancer | inhibits | disease | 0.65 |
| Ischemia | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| CD8 | inhibits | gene | 0.60 |
| GPX4 | activates | gene | 0.60 |
| FERROPTOSIS | activates | gene | 0.60 |
| CANCER | inhibits | gene | 0.60 |
| Ferroptosis | activates | pathway | 0.60 |
| NEURODEGENERATION | inhibits | gene | 0.60 |
| AND | activates | gene | 0.60 |
| AGING | inhibits | gene | 0.60 |
| Ras | expressed_in | protein | 0.60 |
| Fus | inhibits | protein | 0.60 |
| ferroptosis | associated_with | phenotype | 0.50 |
| ferroptosis | activates | phenotype | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PF-670462 | inhibits | drug | 0.90 |
| PF-670462 | promotes | drug | 0.90 |
| PF-670462 | degrades | compound | 0.80 |
| CD8 | inhibits | gene | 0.60 |
| AGING | inhibits | gene | 0.60 |
| NEURODEGENERATION | inhibits | gene | 0.60 |
| CANCER | inhibits | gene | 0.60 |
| FERROPTOSIS | activates | gene | 0.60 |
| GPX4 | associated_with | gene | 0.50 |
| GPX4 | expressed_in | gene | 0.50 |
| GPX4 | activates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||