protein

stathmin-2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about stathmin-2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

59Connections

1Hypotheses

1Analyses

41Outgoing

18Incoming

0Experiments

3Debates

No summary available yet.

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🔬 Protein Info

Gene Symbol	STATHMIN-2
Pathways	MAPK
GeneCards	STATHMIN-2
Human Protein Atlas	STATHMIN-2
Interactions	C9ORF72, STATHMIN
KG Connections	20 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Stathmin-2 (SCG10)

protein · 3087 words

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Pathway Diagram

flowchart TD
    N0["stathmin-2"]
    N1["STATHMIN"]
    N0 -->|"regulates"| N1
    N2["Tdp-43"]
    N0 -->|"regulates"| N2
    N0 -->|"interacts with"| N1
    N0 -->|"interacts with"| N2
    N0 -->|"inhibits"| N1
    N0 -->|"inhibits"| N2
    N3["C9ORF72"]
    N0 -->|"activates"| N3
    N0 -->|"activates"| N1
    N0 -->|"activates"| N2
    N4["Stem Cell"]
    N0 -->|"activates"| N4
    N5["MOTOR NEURONS"]
    N0 -->|"activates"| N5
    N6["Cortex"]
    N0 -->|"activates"| N6
    N7["NEURONS"]
    N0 -->|"activates"| N7
    N8["FIBROBLASTS"]
    N0 -->|"activates"| N8

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 gene
    class N2 pathway
    class N3 gene

Outgoing (41)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:STATHMIN-2	data_in	dataset_row	0.00
axonal maintenance	protective_against	process	0.90
Als	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	inhibits	disease	0.65
Neurodegeneration	regulates	disease	0.65
Frontotemporal Dementia	inhibits	disease	0.65
Dementia	inhibits	disease	0.65
ALS	inhibits	gene	0.60
RNA	inhibits	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
DEMENTIA	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
Tdp-43	inhibits	pathway	0.60
STATHMIN	inhibits	gene	0.60
C9ORF72	expressed_in	gene	0.60
DNA	inhibits	gene	0.60
MOTOR NEURONS	expressed_in	gene	0.60
Neuron	inhibits	cell_type	0.60
TDP-43	inhibits	gene	0.60
Cortex	expressed_in	brain_region	0.55
Stem Cell	expressed_in	cell_type	0.55
Fibroblast	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
Tdp-43	regulates	pathway	0.50
Tdp-43	interacts_with	pathway	0.50
Tdp-43	inhibits	pathway	0.50
Tdp-43	activates	pathway	0.50
Stem Cell	activates	cell_type	0.50
MOTOR NEURONS	activates	concept	0.50
Cortex	activates	brain_region	0.50
NEURONS	activates	concept	0.50
FIBROBLASTS	activates	concept	0.50
IPSC	activates	concept	0.50
MOTOR NEURONS	inhibits	concept	0.50
NEURONS	inhibits	concept	0.50
IPSC	inhibits	concept	0.50
STATHMIN	regulates	gene	0.50
STATHMIN	interacts_with	gene	0.50
STATHMIN	inhibits	gene	0.50
C9ORF72	activates	gene	0.50
STATHMIN	activates	gene	0.50

Incoming (18)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:STATHMIN-2	data_in	dataset_row	0.00
ALS	activates	entity	0.60
FTD	activates	entity	0.60
ALS	inhibits	gene	0.60
RNA	inhibits	gene	0.60
TDP-43	inhibits	gene	0.60
DNA	inhibits	gene	0.60
MOTOR NEURONS	expressed_in	gene	0.60
C9ORF72	expressed_in	gene	0.60
STATHMIN	regulates	entity	0.60
STATHMIN	interacts_with	entity	0.60
C9ORF72	activates	entity	0.60
STATHMIN	activates	entity	0.60
STATHMIN	inhibits	entity	0.60
NEURODEGENERATION	regulates	gene	0.60
DEMENTIA	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
Neurodegeneration	regulates	disease	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Stathmin-2 Splice Switching to Prevent Axonal Degeneration A	0.664	neurodegeneration	RNA binding protein dysregulation across

Mentioning Analyses (1)

Scientific analyses that reference this entity

RNA binding protein dysregulation across ALS FTD AD

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.664

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Structured research brief: Stathmin-2 Splice Switching to Prevent Axonal Degener

archived · Rounds: 2 · Score: 0.73 · 2026-04-28

Hypothesis debate: Stathmin-2 Splice Switching to Prevent Axonal Degeneration Ac

closed · Rounds: 4 · Score: 0.49 · 2026-04-27

RNA binding protein dysregulation across ALS FTD AD

closed · Rounds: 4 · Score: 0.50 · 2026-04-13

Related Research

Hypotheses and analyses mentioning stathmin-2 in their description or question text

No additional research found