Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about stathmin-2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | STATHMIN-2 |
| Pathways | MAPK |
| GeneCards | STATHMIN-2 |
| Human Protein Atlas | STATHMIN-2 |
| Interactions | STATHMIN, C9ORF72 |
| KG Connections | 19 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["stathmin-2"]
N1["STATHMIN"]
N0 -->|"regulates"| N1
N2["Tdp-43"]
N0 -->|"regulates"| N2
N0 -->|"interacts with"| N1
N0 -->|"interacts with"| N2
N0 -->|"inhibits"| N1
N0 -->|"inhibits"| N2
N3["C9ORF72"]
N0 -->|"activates"| N3
N0 -->|"activates"| N1
N0 -->|"activates"| N2
N4["Stem Cell"]
N0 -->|"activates"| N4
N5["MOTOR NEURONS"]
N0 -->|"activates"| N5
N6["Cortex"]
N0 -->|"activates"| N6
N7["NEURONS"]
N0 -->|"activates"| N7
N8["FIBROBLASTS"]
N0 -->|"activates"| N8
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 gene
class N2 pathway
class N3 gene| Target | Relation | Type | Str |
|---|---|---|---|
| STATHMIN | regulates | gene | 0.50 |
| STATHMIN | interacts_with | gene | 0.50 |
| STATHMIN | inhibits | gene | 0.50 |
| C9ORF72 | activates | gene | 0.50 |
| STATHMIN | activates | gene | 0.50 |
| Tdp-43 | regulates | pathway | 0.50 |
| Tdp-43 | interacts_with | pathway | 0.50 |
| Tdp-43 | inhibits | pathway | 0.50 |
| Tdp-43 | activates | pathway | 0.50 |
| Stem Cell | activates | cell_type | 0.50 |
| MOTOR NEURONS | activates | concept | 0.50 |
| Cortex | activates | brain_region | 0.50 |
| NEURONS | activates | concept | 0.50 |
| FIBROBLASTS | activates | concept | 0.50 |
| IPSC | activates | concept | 0.50 |
| MOTOR NEURONS | inhibits | concept | 0.50 |
| NEURONS | inhibits | concept | 0.50 |
| IPSC | inhibits | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Neurodegeneration | regulates | disease | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Stathmin-2 Splice Switching to Prevent Axonal Degeneration A | 0.664 | neurodegeneration | RNA binding protein dysregulation across |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||