gene

STATHMIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STATHMIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

82Connections

1Hypotheses

0Analyses

50Outgoing

25Incoming

Summary

STATHMIN is a gene implicated in neurodegeneration research. Key relationships include: inhibits, therapeutic target, expressed in. Associated with ALS, Als, Amyotrophic Lateral Sclerosis. Connected to 50 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	STATHMIN
Full Name	Stathmin-1 (Oncoprotein 18)
Chromosome	8q11.23
Function	is a microtubule-destabilizing phosphoprotein that plays a critical role in regulating microtubule dynamics, neuronal development, and synaptic plasticity.
Primary Expression	Brain (cortex, hippocampus), Testis, Lymphocytes
Molecular Weight	18 kDa
Amino Acids	149 aa
Exons	6
Pathways	Axonal Transport, Tdp-43
UniProt ID	P16949
NCBI Gene ID	3925
Ensembl ID	ENSG00000117682
OMIM	151440
GeneCards	STATHMIN
Human Protein Atlas	STATHMIN
Associated Diseases	Als, Tumor
Interactions	TDP-43, DNA, NEURODEGENERATION, AMYOTROPHIC LATERAL SCLEROSIS, DEMENTIA, RNA
KG Connections	82 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: STATHMIN — AlphaFold P16949 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    STATHMIN["<b>STATHMIN</b>"]
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    STATHMIN -->|"inhibits"| Amyotrophic_Lateral_Sclerosis
    Neurodegeneration{"Neurodegeneration"}
    STATHMIN -->|"regulates"| Neurodegeneration
    Dementia{"Dementia"}
    STATHMIN -->|"inhibits"| Dementia
    Als{"Als"}
    STATHMIN -->|"inhibits"| Als
    STATHMIN -->|"regulates"| Amyotrophic_Lateral_Sclerosis
    STATHMIN -->|"regulates"| Dementia
    Frontotemporal_Dementia{"Frontotemporal Dementia"}
    STATHMIN -->|"regulates"| Frontotemporal_Dementia
    Ftd{"Ftd"}
    STATHMIN -->|"inhibits"| Ftd
    STATHMIN -->|"associated with"| Als
    STATHMIN -->|"inhibits"| Neurodegeneration
    Tumor{"Tumor"}
    STATHMIN -->|"associated with"| Tumor
    STATHMIN -->|"therapeutic target"| Als
    C9ORF72["C9ORF72"]
    C9ORF72 -->|"expressed in"| STATHMIN
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"regulates"| STATHMIN
    MOTOR_NEURONS["MOTOR NEURONS"]
    MOTOR_NEURONS -->|"expressed in"| STATHMIN
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    AMYOTROPHIC_LATERAL_SCLEROSIS -->|"inhibits"| STATHMIN
    ALS["ALS"]
    ALS -->|"inhibits"| STATHMIN
    ALS -->|"associated with"| STATHMIN
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"associated with"| STATHMIN
    CANCER["CANCER"]
    CANCER -->|"therapeutic target"| STATHMIN
    MICROTUBULES["MICROTUBULES"]
    MICROTUBULES -->|"therapeutic target"| STATHMIN
    ABCB1["ABCB1"]
    ABCB1 -->|"associated with"| STATHMIN
    DNA["DNA"]
    DNA -->|"inhibits"| STATHMIN
    STATHMIN_2["STATHMIN-2"]
    STATHMIN_2 -->|"inhibits"| STATHMIN
    style STATHMIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (57)

Target	Relation	Type	Str
Amyotrophic Lateral Sclerosis	inhibits	disease	0.65
Neurodegeneration	regulates	disease	0.65
Dementia	inhibits	disease	0.65
Als	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Dementia	regulates	disease	0.65
Frontotemporal Dementia	regulates	disease	0.65
Ftd	inhibits	disease	0.65
Als	associated_with	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Tumor	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
ALS	inhibits	disease	0.65
Frontotemporal Dementia	inhibits	disease	0.65
ALS	regulates	disease	0.65
C9ORF72	expressed_in	gene	0.60
ABCB1	associated_with	gene	0.60
STATHMIN-2	regulates	entity	0.60
STATHMIN-2	interacts_with	entity	0.60
STATHMIN-2	activates	entity	0.60
STATHMIN-2	inhibits	entity	0.60
TDP-43	inhibits	gene	0.60
Axonal Transport	regulates	pathway	0.60
DNA	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
Tdp-43	inhibits	pathway	0.60
MOTOR NEURONS	expressed_in	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
DEMENTIA	inhibits	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
CYTOKINES	associated_with	gene	0.60
CANCER	therapeutic_target	gene	0.60
MICROTUBULES	therapeutic_target	gene	0.60
Drug Resistance	therapeutic_target	pathway	0.60
Chemoresistance	therapeutic_target	pathway	0.60
Multidrug Resistance	therapeutic_target	pathway	0.60
RNA	inhibits	gene	0.60
AND	expressed_in	gene	0.60
Cortex	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55
Fibroblast	expressed_in	cell_type	0.55
Stem Cell	expressed_in	cell_type	0.55
Tdp-43	regulates	pathway	0.50
Tdp-43	interacts_with	pathway	0.50
Tdp-43	activates	pathway	0.50
Stem Cell	activates	cell_type	0.50
MOTOR NEURONS	activates	concept	0.50

Incoming (25)

Source	Relation	Type	Str
C9ORF72	expressed_in	gene	0.60
ABCB1	associated_with	gene	0.60
STATHMIN-2	inhibits	gene	0.60
C9ORF72	activates	entity	0.60
TDP-43	inhibits	gene	0.60
TUBULIN	regulates	gene	0.60
STAT3	regulates	gene	0.60
NEFL	interacts_with	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
MOTOR NEURONS	expressed_in	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
ALS	inhibits	gene	0.60
ALS	associated_with	gene	0.60
CYTOKINES	associated_with	gene	0.60
CANCER	therapeutic_target	gene	0.60
MICROTUBULES	therapeutic_target	gene	0.60
DNA	inhibits	gene	0.60
DEMENTIA	inhibits	gene	0.60
ALS	activates	entity	0.60
FTD	activates	entity	0.60
stathmin-2	regulates	protein	0.50
stathmin-2	interacts_with	protein	0.50
stathmin-2	inhibits	protein	0.50
stathmin-2	activates	protein	0.50
Neurodegeneration	regulates	disease	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Stathmin-2 Splice Switching to Prevent Axonal Degeneration A	0.664	neurodegeneration	RNA binding protein dysregulation across

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

STATHMIN

Understanding Entity Pages

Summary

Wiki Pages (21)

STATHMIN — Stathmin-1 (Oncoprotein 18)

TUBB — Tubulin Beta Class I

Stathmin-2 (SCG10)

GDNF Neurons

Transcriptional Dysregulation in Neurodegeneration

UNC13A (Unc-13 Homolog A)

stathmin

TARDBP Protein (TDP-43)

Dentate Gyrus Granule Cells

STMN1 — Stathmin 1

RPS29 — Ribosomal Protein S29

TUBB2B Protein

Stathmin 2 (SCG10) Protein

Stathmin 1 Protein

Cryptic Exon Splicing in TDP-43 Proteinopathy

STMN2 (Stathmin-2)

TDP-43 Proteinopathy Neurons

DCTN1 Dynactin Perry Syndrome Causal Chain

ALS Progression Rate Heterogeneity