Iron Dysregulation as Convergent Pathomechanism

graph TD
    C5AR1["C5AR1"] -->|mediates| Complement_activation["Complement activation"]
    Complement_activation_1["Complement activation"] -->|associated with| neuroinflammation["neuroinflammation"]
    Fingolimod["Fingolimod"] -->|associated with| S1PR1["S1PR1"]
    siponimod["siponimod"] -->|associated with| S1PR1_2["S1PR1"]
    eculizumab["eculizumab"] -.->|inhibits| Complement_activation_3["Complement activation"]
    avacopan["avacopan"] -.->|inhibits| C5AR1_4["C5AR1"]
    C5AR1_5["C5AR1"] -->|mediates| complement_activation["complement activation"]
    complement_activation_6["complement activation"] -->|drives| neuroinflammation_7["neuroinflammation"]
    neuroinflammation_8["neuroinflammation"] -->|causes| myelopathy["myelopathy"]
    S1PR1_9["S1PR1"] -->|controls| immune_cell_trafficking["immune cell trafficking"]
    S1PR1_10["S1PR1"] -->|maintains| blood_spinal_cord_barrier["blood-spinal cord barrier"]
    VEGFA["VEGFA"] -->|increases| vascular_permeability["vascular permeability"]
    style C5AR1 fill:#ce93d8,stroke:#333,color:#000
    style Complement_activation fill:#81c784,stroke:#333,color:#000
    style Complement_activation_1 fill:#81c784,stroke:#333,color:#000
    style neuroinflammation fill:#4fc3f7,stroke:#333,color:#000
    style Fingolimod fill:#4fc3f7,stroke:#333,color:#000
    style S1PR1 fill:#4fc3f7,stroke:#333,color:#000
    style siponimod fill:#4fc3f7,stroke:#333,color:#000
    style S1PR1_2 fill:#4fc3f7,stroke:#333,color:#000
    style eculizumab fill:#4fc3f7,stroke:#333,color:#000
    style Complement_activation_3 fill:#81c784,stroke:#333,color:#000
    style avacopan fill:#4fc3f7,stroke:#333,color:#000
    style C5AR1_4 fill:#ce93d8,stroke:#333,color:#000
    style C5AR1_5 fill:#ce93d8,stroke:#333,color:#000
    style complement_activation fill:#81c784,stroke:#333,color:#000
    style complement_activation_6 fill:#81c784,stroke:#333,color:#000
    style neuroinflammation_7 fill:#4fc3f7,stroke:#333,color:#000
    style neuroinflammation_8 fill:#4fc3f7,stroke:#333,color:#000
    style myelopathy fill:#ef5350,stroke:#333,color:#000
    style S1PR1_9 fill:#ce93d8,stroke:#333,color:#000
    style immune_cell_trafficking fill:#4fc3f7,stroke:#333,color:#000
    style S1PR1_10 fill:#ce93d8,stroke:#333,color:#000
    style blood_spinal_cord_barrier fill:#4fc3f7,stroke:#333,color:#000
    style VEGFA fill:#ce93d8,stroke:#333,color:#000
    style vascular_permeability fill:#4fc3f7,stroke:#333,color:#000