Contents

CHRNA7 Gene

🧬 Gene Info

Gene Symbol	CHRNA7
Chromosome	15q13.3
Protein Type	Channel
Target Class	Protein
Function	The nicotinic acetylcholine receptor alpha 7 (α7 nAChR) is a homomeric ligand-gated ion channel highly expressed in the brain, particularly in the hippocampus, cortex, and basal ganglia.
Mechanism of Action	Prioritized from 1 SciDEX hypotheses, including: Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain Anti-Inflammatory Communication
Primary Expression	the brain, particularly in the hippocampus, cortex, and basal ganglia
Druggability	Undruggable (0.23)
Amino Acids	502 aa
Exons	10
Pathways	NF-κB, MAPK
Ensembl ID	ENSG00000175344
GeneCards	CHRNA7
Human Protein Atlas	CHRNA7
Extracellular N-terminal domain	Contains the ligand-binding site at the interface between subunits
Associated Diseases	Als, Alzheimer, bipolar disorder, cancer, COLORECTAL CANCER
Known Drugs/Compounds	valproic acid
Interactions	ABCB1, Akt, AKT, AKT1, ALZHEIMER, ALZHEIMER'S DISEASE
SciDEX Target	View Target Profile
SciDEX Hypotheses	Enhancing Vagal Cholinergic Signaling to Restore G Cholinergic Attention Modulation Hypothesis
KG Connections	410 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Knowledge Graph