Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CSGA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CSGA |
| Key Genes/Proteins | amyloid beta, contact-phase proteins, Rb |
| Related Diseases | Als, Parkinson, Alzheimer, neurodegeneration |
| Related Pathways | biofilm formation, gut microbiome |
Knowledge base pages for this entity
graph TD
CSGA["CSGA"]
CSGA -->|"regulates"| Als["Als"]
CSGA -->|"regulates"| Parkinson["Parkinson"]
CSGA -->|"interacts"| alpha_synuclein["alpha-synuclein"]
CSGA -->|"implicated in"| Parkinson_s_disease["Parkinson's disease"]
CSGA -->|"contributes to"| biofilm_formation["biofilm formation"]
fibrinogen["fibrinogen"] -->|"inhibits"| CSGA
AMYLOID["AMYLOID"] -->|"expressed in"| CSGA
PARKINSON["PARKINSON"] -->|"regulates"| CSGA
APP["APP"] -->|"activates"| CSGA| Target | Relation | Type | Str |
|---|---|---|---|
| Als | regulates | disease | 0.65 |
| Parkinson | regulates | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| biofilm formation | contributes_to | pathway | 0.60 |
| amyloid beta | interacts_with | protein | 0.60 |
| innate immune system | modulates | cell_type | 0.60 |
| contact-phase proteins | interacts_with | protein | 0.60 |
| gut microbiome | expressed_in | pathway | 0.60 |
| neurodegeneration | associated_with | disease | 0.60 |
| Rb | associated_with | protein | 0.60 |
| Rb | interacts_with | protein | 0.60 |
| APP | activates | gene | 0.60 |
| alpha-synuclein | interacts_with | protein | 0.60 |
| Parkinson's disease | implicated_in | disease | 0.60 |
| Alzheimer's disease | implicated_in | disease | 0.60 |
| PARKINSON | regulates | gene | 0.60 |
| Alpha-Synuclein | regulates | protein | 0.60 |
| AMYLOID | expressed_in | gene | 0.60 |
| AMYLOID | associated_with | gene | 0.60 |
| App | associated_with | protein | 0.60 |
| AMYLOID | inhibits | gene | 0.60 |
| AMYLOID | regulates | gene | 0.60 |
| AMYLOID | interacts_with | gene | 0.60 |
| AMYLOID | activates | gene | 0.60 |
| Fus | expressed_in | protein | 0.60 |
| GPR109A | debate_co_mention | gene | 0.45 |
| neuroinflammation | debate_co_mention | process | 0.45 |
| TDC | debate_co_mention | gene | 0.45 |
| DDC | debate_co_mention | gene | 0.45 |
| HDAC | debate_co_mention | gene | 0.45 |
| neurodegeneration | implicated_in | disease | 0.40 |
| TLR4 | co_associated_with | gene | 0.40 |
| GPR109A | co_associated_with | gene | 0.40 |
| TDC | co_associated_with | gene | 0.40 |
| ms | implicated_in | disease | 0.35 |
| parkinson | implicated_in | disease | 0.35 |
| als | implicated_in | disease | 0.35 |
| alzheimer | implicated_in | disease | 0.35 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-8b7727c1 | targets_gene | hypothesis | 0.90 |
| fibrinogen | inhibits | protein | 0.60 |
| APP | activates | gene | 0.60 |
| AMYLOID | expressed_in | gene | 0.60 |
| PARKINSON | regulates | gene | 0.60 |
| AMYLOID | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| AMYLOID | inhibits | gene | 0.60 |
| AMYLOID | regulates | gene | 0.60 |
| AMYLOID | interacts_with | gene | 0.60 |
| AMYLOID | activates | gene | 0.60 |
| h-8b7727c1 | targets | hypothesis | 0.50 |
| AADC | debate_co_mention | gene | 0.45 |
| AGER | debate_co_mention | gene | 0.45 |
| CHRNA7 | debate_co_mention | gene | 0.45 |
| TDC | co_discussed | gene | 0.40 |
| TLR4 | co_discussed | gene | 0.40 |
| DDC | co_discussed | gene | 0.40 |
| GPR109A | co_discussed | gene | 0.40 |
| CHRNA7 | co_discussed | gene | 0.40 |
| AGER | co_discussed | gene | 0.40 |
| AGER | co_associated_with | gene | 0.40 |
| CHRNA7 | co_associated_with | gene | 0.40 |
| HDAC | co_discussed | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro | 0.488 | neurodegeneration | What are the mechanisms by which gut mic |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.617
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| 7-ketocholesterol as a theranostic target: potential applications and future per [PMID:41936993] | Lizard G, Sassi K, Mackrill JJ, Ghzaiel | Chem Phys Lipids | 2026 | 0 |
| Computational examination of magainin-I-KL mediated disruption of E. coli biofil [PMID:41724836] | Vinutha AS, Akshay S, Sree Agash SG, Cha | Archives of microbiology | 2026 | 0 |
| The cytoplasmic protein YedX is a potent inhibitor of CsgA amyloid assembly in E [PMID:41581877] | Gurnani B, Jain N | The Journal of biological chem | 2026 | 0 |
| Biofilm-Associated Amyloid Proteins Linked with the Progression of Neurodegenera [PMID:40141340] | Singh AA, Khan F, Song M | International journal of molec | 2025 | 0 |
| E.coli-derived CsgA-peptides stimulate cytokine production in microglia and lead [PMID:41476670] | Mygind L, Jensen G, Neesgaard V, Krohn K | Brain, behavior, & immunity - | 2025 | 0 |
| [WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268] | Wieschollek S, Forster S, Megerle K | Handchirurgie, Mikrochirurgie, | 2022 | 0 |
| Using Caenorhabditis elegans to Model Therapeutic Interventions of Neurodegenera [PMID:35571084] | Wang C, Zheng C | Frontiers in pharmacology | 2022 | 0 |
| Genome-wide screen identifies curli amyloid fibril as a bacterial component prom [PMID:34413194] | Wang C, Lau CY, Ma F, Zheng C | Proceedings of the National Ac | 2021 | 0 |
| Engineering complex communities by directed evolution. [PMID:33986540] | Chang CY, Vila JCC, Bender M, Li R, Mank | Nature ecology & evolution | 2021 | 0 |
| Successful Nonoperative Treatment of Osteochondritis Dissecans of the Humeral Ca [PMID:34825100] | Tajika T, Kuboi T, Endo F, Hatori Y, Sai | Progress in rehabilitation med | 2021 | 0 |
| Crosstalk Between Alpha-Synuclein and Other Human and Non-Human Amyloidogenic Pr [PMID:32538869] | Werner T, Horvath I, Wittung-Stafshede P | Journal of Parkinson's disease | 2020 | 0 |
| 7-Ketocholesterol- and 7β-Hydroxycholesterol-Induced Peroxisomal Disorders in Gl [PMID:33417205] | ["Nury T", "Yammine A", "Menetrier F", " | Advances in experimental medic | 2020 | 0 |
| Unified single-cell analysis of testis gene regulation and pathology in five mou [PMID:31237565] | Jung M, Wells D, Rusch J, Ahmad S, March | eLife | 2019 | 0 |
| Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parki [PMID:27912057] | ["Sampson TR", "Debelius JW", "Thron T", | Cell | 2017 | 0 |
| Anti-aging effects of coffee. [PMID:28854150] | Takahashi K, Ishigami A | Aging | 2017 | 0 |
| The chronic myeloid leukemia stem cell: stemming the tide of persistence. [PMID:28159740] | Holyoake TL, Vetrie D | Blood | 2017 | 0 |
| Neurodegeneration in tauopathies and synucleinopathies. [PMID:27344208] | ["Foguem C", "Kamsu-Foguem B"] | Revue neurologique | 2016 | 0 |
| Three months of simvastatin therapy vs. placebo for severe portal hypertension i [PMID:26321186] | Pollo-Flores P, Soldan M, Santos UC, Kun | Digestive and liver disease : | 2015 | 0 |