| Gene Symbol | TLR4 |
| Full Name | Toll-Like Receptor 4 |
| Chromosome | 9q33.1 |
| Protein Type | Receptor |
| Target Class | Receptor |
| Function | LBP transfer: LPS-binding protein transfers LPS to CD14 |
| Mechanism of Action | Small molecule antagonist or antibody blocking TLR4-mediated neuroinflammatory signaling |
| Druggability | Low (0.41) |
| Clinical Stage | Phase III |
| Molecular Weight | 95 kDa |
| Pathways | Akt, Amyloid, Apoptosis, Autophagy, Cell Division |
| UniProt ID | O00206 |
| NCBI Gene ID | 7099 |
| Ensembl ID | ENSG00000136869 |
| OMIM | 603030 |
| GeneCards | TLR4 |
| Human Protein Atlas | TLR4 |
| Associated Diseases | ALS, ATP, Aging, Alzheimer, Alzheimer'S Disease |
| Known Drugs/Compounds | IRN, Gastrodin, hesperetin, DHT, FREE HEME, IRINOTECAN |
| Interactions | SNCA, CD68, MMP2, EGFR, GSDMD, MYD88 |
| SciDEX Target | View Target Profile (4 clinical trials) |
| SciDEX Hypotheses | Selective TLR4 Modulation to Prevent Gut-Derived N |
| KG Connections | 2220 knowledge graph edges |
| Databases | GeneCardsHPASTRING |