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biomarker 1,499 words KG: GLUTAMATE
Contents

Glutamate - Excitotoxicity and Neurodegeneration Biomarker

🔬 Protein Info
Gene SymbolGLUTAMATE
Complementary to protein biomarkersGlutamate provides orthogonal information to Aβ (A) and tau (T) markers
Network dysfunction assessmentCaptures hyperexcitability not reflected in structural biomarkers
Therapeutic monitoringAnti-excitotoxic treatments should show glutamate normalization
Prognostic valueElevated glutamate predicts progression in AD, PD, and ALS
Associated DiseasesCOGNITIVE DECLINE, EPILEPSY, EXCITOTOXICITY, FERROPTOSIS, GLUTAMATE EXCITOTOXICITY, GLYCOLYSIS
Known Drugs/CompoundsKETAMINE
InteractionsAKT, AMPK, APOE, APP, BIN1, PARKIN
KG Connections610 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

Wikipedia

Related Hypotheses (157)

Lysosomal Calcium Channel Modulation Therapy
Score: 0.70Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70Axonal RNA Transport Reconstitution
Score: 0.70Mitochondrial Transfer Pathway Enhancement
Score: 0.70Complement C1q Mimetic Decoy Therapy
Score: 0.69Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69Ocular Immune Privilege Extension
Score: 0.69Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69Extracellular Matrix Stiffness Modulation
Score: 0.69Ganglioside Rebalancing Therapy
Score: 0.69Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69Cross-Seeding Prevention Strategy
Score: 0.69Hypocretin-Neurogenesis Coupling Therapy
Score: 0.69Lysosomal Positioning Dynamics Modulation
Score: 0.69TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68Flotillin-1 Stabilization Compounds
Score: 0.68R-Loop Resolution Enhancement Therapy
Score: 0.68Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68
← Prevpg 4/8Next →

Related Analyses (30)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · completed · Score: 0.40

See Also (15)

Beta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 139 hypothesesChina Neurodegeneration Epidemiology
disease · Pages share 139 hypothesesNeuroimaging for Parkinsonian Syndromes (NCT03872102)
clinical · Pages share 27 hypothesesSynaptic Biomarkers in Neurodegeneration
biomarker · Pages share 139 hypothesesOlfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 139 hypotheses

Knowledge Graph (12 edges)

GLUTAMATE associated_with EXCITOTOXICITY
MACROPHAGES activates GLUTAMATE
GLUTAMATE inhibits AXONS
GLUTAMATE causes EXCITOTOXICITY
FERROPTOSIS co_discussed GLUTAMATE
GLUTAMATE co_discussed GPX4
GLUTAMATE co_discussed MITOCHONDRIA
BRAINSTEM co_discussed GLUTAMATE
FOXO3 co_discussed GLUTAMATE
GLUTAMATE co_discussed OPTN

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