| Gene Symbol | TAU |
| Chromosome | 17q21.31 |
| Protein Family | MAPT family |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | neurons, where they bind to microtubules and promote their polymerization and stability |
| Subcellular Localization | Axons, Neurons |
| Molecular Weight | 45-65 kDa (isoform dependent) |
| Amino Acids | 441 aa |
| Pathways | Extracellular Aggregation, Hyperphosphorylation, Neurofibrillary Tangle Formation, Protein Assembly, Synapse Pathology |
| GeneCards | TAU |
| Human Protein Atlas | TAU |
| Microtubule stabilization | tau binds to tubulin to promote microtubule assembly and stability |
| Axonal transport | facilitates vesicle and organelle trafficking along axons |
| Neuronal polarity | contributes to axon initial segment integrity |
| CSF t-tau | <300 pg/mL (age-dependent; higher in elderly individuals over 70 years) |
| Associated Diseases | ALZHEIMER, alzheimers_disease, Alzheimer's disease, apoptosis, frontotemporal_dementia, hippocampal atrophy |
| Known Drugs/Compounds | EGCG, rutin, Urolithin A |
| Interactions | Amyloid-β, APOE4, ASK1, Aβ, CDK5, GSK-3β |
| SciDEX Hypotheses | TREM2 should remain under review until replicated APOE should remain under review until replicated GFAP should remain under review until replicated (+2 more) |
| KG Connections | 139 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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