Contents

Total Tau (t-Tau) - Biomarker

🔬 Protein Info

Gene Symbol	TAU
Chromosome	17q21.31
Protein Family	MAPT family
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	neurons, where they bind to microtubules and promote their polymerization and stability
Subcellular Localization	Axons, Neurons
Molecular Weight	45-65 kDa (isoform dependent)
Amino Acids	441 aa
Pathways	Extracellular Aggregation, Hyperphosphorylation, Neurofibrillary Tangle Formation, Protein Assembly, Synapse Pathology
GeneCards	TAU
Human Protein Atlas	TAU
Category	Protein Biomarker
Target	Total tau protein
Sample Type	CSF, Plasma
Clinical Utility	Axonal damage, neurodegeneration
Associated Diseases	ALZHEIMER, Alzheimer's disease, apoptosis, neurodegeneration
Known Drugs/Compounds	rutin, Urolithin A, EGCG
Interactions	Amyloid-β, APOE4, heat shock proteins, GSK-3β, ASK1, p38 MAPK
KG Connections	85 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Knowledge Graph