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mechanism 3,900 words KG: DNA
Contents

DNA Damage Response in Corticobasal Syndrome

⚙ Mechanism Info
NameDNA
Key Genes/ProteinsA2M, ABCA7, ABCB1, ABCD3, ABCG1, ACC
Related DiseasesAD
Related PathwaysAdaptive Immunity
Linked Hypotheses35 hypotheses

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Wikipedia

Related Hypotheses (46)

Exposed amyloidogenic segments (β-sheet propensity residues)
Score: 0.84J-protein substrate specificity codes enable HSP70 discrimin
Score: 0.84ATM Kinase Hyperactivation Triggers DNA Damage Response Over
Score: 0.84J-protein co-chaperone system mediates selective autophagy t
Score: 0.83Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re
Score: 0.80Mitochondrial DNA-Driven AIM2 Inflammasome Activation in Neu
Score: 0.80Senescent Cell Mitochondrial DNA Release
Score: 0.74Temporal CAG Repeat Stabilization via CRISPR-Mediated DNA Mi
Score: 0.68Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68Oligodendrocyte DNA Repair Enhancement Therapy
Score: 0.66PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Damage and Su
Score: 0.66J-protein co-chaperone repertoire enables selective recognit
Score: 0.64Neuronal TET1 Upregulation Reactivates Immediate-Early Genes
Score: 0.64H4: Age-Related Hsp70 Chaperone Decline Blocks Granule Rever
Score: 0.58TREM2 Promoter Silencing via DNA Hypermethylation
Score: 0.58Oligodendrocyte DNA Repair Enhancement
Score: 0.55Multi-Chaperone System Co-Activation Prevents Saturation Thr
Score: 0.55HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
Score: 0.54Epigenetic Reprogramming Required for Late-Stage Interventio
Score: 0.54Transient Chaperone Priming Prior to Seed Inoculation Preven
Score: 0.54
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Knowledge Graph (12 edges)

DNA associated_with TDP-43
DNA associated_with neural stem cells
DNA associated_with neurons
DNA associated_with oligodendrocytes
DNA associated_with KRAS
DNA associated_with TP53
DNA associated_with PARKIN
DNA inhibits neural stem cells
DNA associated_with FUS
DNA associated_with PARP1

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