gene 772 words KG: CD40
Contents

CD40 - Cluster of Differentiation 40

🧬 Gene Info
Gene SymbolCD40
Full NameCluster of Differentiation 40
Chromosome20q12
Protein FamilyTNF receptor superfamily
FunctionCD40-CD40L signaling is central to immune function
Primary ExpressionAD brain by microglia and astrocytes - CD40-CD40L interaction promotes: - Microglial activation - Pro-i
Molecular Weight48 kDa
Amino Acids277 aa
Exons9
PathwaysNF-κB, MAPK pathway, PI3K
GeneCardsCD40
Human Protein AtlasCD40
Associated DiseasesAD, ALI, Autoimmune, cancer, disease
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AND, AQP4, CD8, C-FOS
KG Connections99 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (1)

IL-10-Producing B10 Cells Establish AQP4-Specific Peripheral
Score: 0.65

Knowledge Graph (12 edges)

CD40 expressed_in AQP4
CD40 therapeutic_target MTOR
AQP4 expressed_in CD40
CLOCK regulates CD40
CD40 implicated_in cancer
CD40 implicated_in infection
MTOR therapeutic_target CD40
TNF regulates CD40
CD40 regulates CCL5
CD4 expressed_in CD40

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