gene 772 words KG: CD40
Contents

CD40 - Cluster of Differentiation 40

🧬 Gene Info
Gene SymbolCD40
Full NameCluster of Differentiation 40
Chromosome20q12
Protein FamilyTNF receptor superfamily
FunctionCD40-CD40L signaling is central to immune function
Primary ExpressionAD brain by microglia and astrocytes - CD40-CD40L interaction promotes: - Microglial activation - Pro-i
Molecular Weight48 kDa
Amino Acids277 aa
Exons9
PathwaysNF-κB, MAPK pathway, PI3K
GeneCardsCD40
Human Protein AtlasCD40
Associated DiseasesAD, ALI, Autoimmune, cancer, disease
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AND, AQP4, CD8, C-FOS
KG Connections99 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (6)

SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
Circadian Clock-Autophagy Synchronization
Score: 0.76
Aquaporin-4 Polarization Rescue
Score: 0.73
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (3)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (7)

AQP4 (Aquaporin-4 Gene)
gene · KG edge: activates
CD4 Gene
gene · KG edge: expressed_in
Autoimmune Hypothesis in Alzheimer's Disease
hypothesis · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in

Knowledge Graph (12 edges)

CD40 expressed_in AQP4
CD40 therapeutic_target MTOR
AQP4 expressed_in CD40
CLOCK regulates CD40
CD40 implicated_in cancer
CD40 implicated_in infection
MTOR therapeutic_target CD40
TNF regulates CD40
CD40 regulates CCL5
CD4 expressed_in CD40

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.