cell 669 words KG: NMDA 2026-03-24
kind:cell-typesection:cell-typesstate:published
Contents

Prefrontal Cortex Pyramidal Neurons in Executive Function

🧫 Cell Type Info
Cell TypePrefrontal Cortex Pyramidal Neurons in Executive Function
Also Known AsGRIN2B, GRIN1
Key Pathwaysglutamate signaling, unfolded protein response, oxidative stress response, mitochondrial function, sphingolipid metabolism
Associated DiseasesAlzheimer'S Disease, disease
Related GenesPSD-95, SQSTM1, VPS35
Linked Hypotheses42 hypotheses

Knowledge Graph

Related Hypotheses (7)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.44

Related Analyses (10)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Mitochondrial transfer between neurons and glia
neurodegeneration · archived

Related Experiments (16)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

Knowledge Graph (12 edges)

NMDA associated_with PSD-95
NMDA participates_in glutamate signaling
NMDA targets PSD95
NMDA activates neurodegeneration
NMDA participates_in mitochondrial function
NMDA participates_in unfolded protein response
NMDA participates_in sphingolipid metabolism
NMDA participates_in neurotrophin signaling
NMDA expressed_in oligodendrocytes
NMDA participates_in MAPK signaling