protein

P2Y12

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P2Y12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

88Connections

1Hypotheses

0Analyses

50Outgoing

30Incoming

Summary

P2Y12 is a protein involved in neurodegeneration research. Key relationships include: activates, targets, associated with. Associated with Chronic Kidney Disease, Diabetes Mellitus, Thrombosis. Connected to 13 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	P2Y12
Function	P2Y12 on microglia mediates response to amyloid-beta[@moorhead2019]. The receptor is involved in microglial recruitment to plaques. Genetic variants may affect AD risk.
Molecular Weight	39.4 kDa
Pathways	Pik3, PI3K pathway, purinergic signaling, synaptic plasticity, PI3K-AKT-mTOR signaling
GeneCards	P2Y12
Human Protein Atlas	P2Y12
Associated Diseases	ALS, Chronic Kidney Disease, DIABETES, disease, epilepsy
Interactions	TREM2, PI3K, PSP, TMEM119, ALZHEIMER, P2RY12
KG Connections	88 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    P2Y12["<b>P2Y12</b>"]
    Platelet_Aggregation["Platelet Aggregation"]
    P2Y12 -->|"activates"| Platelet_Aggregation
    Platelet["Platelet"]
    P2Y12 -->|"expressed_in"| Platelet
    Thrombosis{"Thrombosis"}
    P2Y12 -->|"involved_in"| Thrombosis
    ADCY["ADCY"]
    P2Y12 -.->|"inhibits"| ADCY
    cAMP["cAMP"]
    P2Y12 -.->|"downregulates"| cAMP
    Pik3["Pik3"]
    P2Y12 -->|"activates"| Pik3
    Adp["Adp"]
    Adp -->|"activates"| P2Y12
    Clopidogrel["Clopidogrel"]
    Clopidogrel -->|"targets"| P2Y12
    Ticagrelor["Ticagrelor"]
    Ticagrelor -->|"targets"| P2Y12
    style P2Y12 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (58)

Target	Relation	Type	Str
PI3K pathway	activates	pathway	0.80
purinergic signaling	participates_in	pathway	0.75
microglia	expressed_in	cell_type	0.75
Alzheimer's disease	regulates	disease	0.65
ALS	associated_with	disease	0.60
epilepsy	associated_with	disease	0.60
cardiovascular disease	regulates	disease	0.60
autophagy pathway	participates_in	pathway	0.60
diabetes	associated_with	disease	0.60
multiple sclerosis	activates	disease	0.60
Alzheimer's disease	activates	disease	0.60
neuroinflammation	activates	disease	0.60
blood-brain barrier	participates_in	pathway	0.60
glymphatic clearance	participates_in	pathway	0.60
neurodegeneration	biomarker_for	disease	0.60
neurodegeneration	interacts_with	disease	0.60
TREM2	activates	gene	0.55
tauopathy	regulates	disease	0.55
neuroinflammation	inhibits	disease	0.55
synaptic plasticity	participates_in	pathway	0.55
neurodegeneration	regulates	disease	0.55
neuroinflammation	regulates	disease	0.55
PI3K	activates	gene	0.55
PI3K-AKT-mTOR signaling	participates_in	pathway	0.55
neurons	expressed_in	cell_type	0.55
tauopathy	expressed_in	disease	0.55
PSP	activates	gene	0.55
unfolded protein response	participates_in	pathway	0.55
DAM microglia	expressed_in	cell_type	0.55
tauopathy	activates	disease	0.55
oxidative stress response	participates_in	pathway	0.55
Alzheimer's disease	inhibits	disease	0.55
astrocytes	expressed_in	cell_type	0.55
neurodegeneration	activates	disease	0.55
PSP	inhibits	gene	0.55
TMEM119	activates	gene	0.55
atherosclerosis	regulates	disease	0.50
DIABETES	associated_with	disease	0.50
DIABETES MELLITUS	associated_with	concept	0.50
disease	associated_with	disease	0.50
Chronic Kidney Disease	associated_with	disease	0.50
ALZHEIMER	activates	gene	0.50
Alzheimer'S Disease	activates	disease	0.50
MULTIPLE SCLEROSIS	activates	disease	0.50
disease	activates	disease	0.50
ALZHEIMER'S	activates	concept	0.50
SEROTONIN	activates	concept	0.50
Cortex	interacts_with	brain_region	0.50
CEREBRAL CORTEX	interacts_with	concept	0.50
BRAIN INJURY	regulates	concept	0.50

Incoming (30)

Source	Relation	Type	Str
ATP	associated_with	gene	0.60
P2RY12	activates	gene	0.55
CD47	activates	gene	0.55
GFAP	activates	gene	0.55
ATP	activates	gene	0.55
P2X7	activates	gene	0.55
CD39	activates	gene	0.55
P2X7	inhibits	gene	0.55
AMYLOID	activates	gene	0.50
GENES	co_discussed	gene	0.50
NMDA	activates	protein	0.50
PI3K	activates	protein	0.50
Autophagy	regulates	process	0.50
P2RY12	regulates	gene	0.50
P2Y12 RECEPTOR	regulates	protein	0.50
P2Y12 RECEPTOR	expressed_in	protein	0.50
P2Y12 RECEPTOR	activates	protein	0.50
P2Y12 RECEPTOR	associated_with	protein	0.50
P2Y12 RECEPTOR	inhibits	protein	0.50
Neuroinflammation	activates	process	0.50
microglia	interacts_with	cell_type	0.50
P2Y12 RECEPTOR	interacts_with	protein	0.50
microglia	associated_with	cell_type	0.50
microglia	regulates	cell_type	0.50
microglia	inhibits	cell_type	0.50
EPILEPSY	interacts_with	gene	0.50
P2RY12	associated_with	gene	0.50
CCR5	associated_with	gene	0.50
CDH23	associated_with	gene	0.50
ATP	co_expressed_with	protein	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Purinergic P2Y12 Inverse Agonist Therapy	0.480	neurodegeneration	Synaptic pruning by microglia in early A

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (16)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Beyond Activation: Characterizing Microglial Functional Phenotypes. [PMID:34571885]	Lier J, Streit WJ, Bechmann I	Cells	2021	2
The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting auto [PMID:32160082]	Pi S, Mao L, Chen J, Shi H, Liu Y, Guo X	Autophagy	2021	2
Role of P2Y(12) Receptor in Thrombosis. [PMID:27628007]	Zhang Y, Zhang S, Ding Z	Adv Exp Med Biol	2017	1
P2 purinergic receptors in systemic lupus erythematosus: from experimental findi [PMID:41825304]	Renaudineau Y, Brooks W	Current opinion in immunology	2026	0
The Dual Role of P2RY12: Impact of Polymorphism and Expression on Ischemic Event [PMID:41903930]	Li J, Gong Z, Wang S, Gu J, Wu S, Pang J	Journal of thrombosis and haem	2026	0
Association of P2Y12 Polymorphisms With the Risk of Ischemic Stroke Subtypes. [PMID:41761998]	Wu C, Chen Y, Chen J, Wei X, Zhang Z	Revista de neurologia	2026	0
[Advantageous therapeutic pathways and mechanisms of Jianpi Huogu Formula in tre [PMID:41814722]	Li T, Zhang C, Jia Y, Chen WH, Lin N, Zh	Zhongguo Zhong yao za zhi = Zh	2026	0
Clopidogrel Administration Impairs Neurovascular Unit Recovery and Exacerbates A [PMID:41898413]	Paul M, Paul JW, Hinwood M, Hood RJ, Mar	International journal of molec	2026	0
Pan-cancer T cell atlas links a cellular stress response state to immunotherapy [PMID:37248301]	["Chu Y", "Dai E", "Li Y", "Han G", "Pei	Nature medicine	2023	0
Immune-related adverse events predict responses to PD-1 blockade immunotherapy i [PMID:33890283]	["Lu L", "Xing K", "Wei W", "Ling Y", "L	International journal of cance	2021	0
Endogenous TLR2 ligand embedded in the catalytic region of human cysteinyl-tRNA [PMID:32461342]	["Cho S", "Kim S", "Lee Y", "Song E", "K	Journal for immunotherapy of c	2020	0
Assemblies of Perisomatic GABAergic Neurons in the Developing Barrel Cortex. [PMID:31780328]	["Modol L", "Bollmann Y", "Tressard T",	Neuron	2020	0
A Unique Microglia Type Associated with Restricting Development of Alzheimer's D [PMID:28602351]	["Keren-Shaul H", "Spinrad A", "Weiner A	Cell	2017	0
Platelet P2Y12 receptor inhibition by thienopyridines: status and future. [PMID:19678800]	["Porto I", "Giubilato S", "De Maria G",	Expert opinion on investigatio	2009	0
Pten regulates neuronal arborization and social interaction in mice. [PMID:16675393]	["Kwon C", "Luikart B", "Powell C", "Zho	Neuron	2006	0
Randomized comparison of prasugrel (CS-747, LY640315), a novel thienopyridine P2 [PMID:15967851]	["Wiviott S", "Antman E", "Winters K", "	Circulation	2005	0

P2Y12

Understanding Entity Pages

Summary

Wiki Pages (20)

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Therapeutics

Microglial Cells — Cell Type Hierarchy

Section 153: Virtual Reality Therapy Protocols in CBS/PSP

nfl-blood-test-guided-therapy

Section 156: Pet Therapy and Animal-Assisted Interventions in CBS/PSP

Section 249: Advanced LSVT Voice and Speech Therapy in CBS/PSP

microglial-synaptic-pruning-dysregulation

Microglia Activation Mechanism

Section 240: Advanced Narrative Therapy and Life Review in CBS/PSP

Section 99: Purinergic Signaling and P2X/P2Y Receptors in CBS/PSP

section-181-advanced-music-rhythm-therapy-cbs-psp

Neuroinflammation Comparison — AD/PD/ALS/FTD/HD

Microglia

CBS Microglial Neuroimmune Axis

Section 250: Advanced Vestibular and Balance Therapy in CBS/PSP

Advanced Metal Chelation Therapy in CBS/PSP

PROTAC Therapy for Parkinson's Disease