cell 647 words KG: NMDA 2026-03-24
kind:cell-typesection:cell-typesstate:published
Contents

VTA Dopamine Neurons in Schizophrenia

🧫 Cell Type Info
Cell TypeVTA Dopamine Neurons in Schizophrenia
Also Known AsGRIN2B, GRIN1
Key Pathwaysglutamate signaling, unfolded protein response, oxidative stress response, mitochondrial function, sphingolipid metabolism
Associated DiseasesAlzheimer'S Disease, disease
Related GenesPSD-95, SQSTM1, VPS35
Linked Hypotheses42 hypotheses

Knowledge Graph

Related Hypotheses (6)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.41
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.38
Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36

Related Analyses (11)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

Related Experiments (4)

Mechanism: Selective Vulnerability of Dopaminergic Neurons i
validation · proposed · Score: 0.40
iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90
Autophagy receptor identification for stress granule elimina
exploratory · proposed · Score: 0.90
Autophagy receptor knockout effects on stress granule accumu
exploratory · proposed · Score: 0.85

Knowledge Graph (12 edges)

NMDA associated_with PSD-95
NMDA participates_in glutamate signaling
NMDA targets PSD95
NMDA activates neurodegeneration
NMDA participates_in mitochondrial function
NMDA participates_in unfolded protein response
NMDA participates_in sphingolipid metabolism
NMDA participates_in neurotrophin signaling
NMDA expressed_in oligodendrocytes
NMDA participates_in MAPK signaling