Contents

DAPK1 Gene

🧬 Gene Info

Gene Symbol	DAPK1
Full Name	Death-Associated Protein Kinase 1
Chromosome	9p21.3
Protein Family	CaMK (Calcium/Calmodulin-dependent protein kinase) family
Protein Type	Serine/Threonine Kinase
Function	encodes a calcium/calmodulin-dependent serine/threonine kinase that functions as a positive regulator of apoptosis, autophagy, and programmed cell death.
Primary Expression	the brain, particularly in neurons, where it integrates calcium signaling with cell death pathways
Subcellular Localization	and interactions
Molecular Weight	160 kDa
Amino Acids	1056 aa
Pathways	PI3K
UniProt ID	P53355
NCBI Gene ID	1612
Ensembl ID	ENSG00000196730
OMIM	600730
GeneCards	DAPK1
Human Protein Atlas	DAPK1
Associated Diseases	AD, ALS, AMI, Alzheimer, Alzheimer's disease
Interactions	HSPG2, IL1B, APP, EIF2AK2, HMGCR, PARP1
SciDEX Hypotheses	DAPK1 Inhibition as Dual-Mechanism Neuroprotection
KG Connections	191 knowledge graph edges
Databases	GeneCards HPA STRING

Knowledge Graph