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entity 584 words KG: autophagy
Contents

Autophagy

🔬 Protein Info
Gene Symbolautophagy
AliasesAutophagy-lysosomal pathway, Cellular self-eating
FunctionProtein degradation; Organelle turnover; Quality control
PathwaysmTOR pathway, AMPK signaling, Beclin-1 complex
Associated Diseasesadipogenesis, ALS, Alzheimer's disease, Alzheimer's disease and related dementias, AMD, amyotrophic lateral sclerosis
Known Drugs/Compoundsarsenic, ATTECs, calycosin, Calycosin, CDK4/6 inhibitors, cocaine
KG Connections718 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Wikipedia

Related Hypotheses (118)

Multi-Modal Stress Response Harmonization
Score: 0.76GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74PARP1 Inhibition Therapy
Score: 0.74SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71Membrane Cholesterol Gradient Modulators
Score: 0.71Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70Microglial Purinergic Reprogramming
Score: 0.70Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70Mitochondrial Transfer Pathway Enhancement
Score: 0.70
← Prevpg 4/6Next →

Related Analyses (30)

How do non-cell autonomous effects of autophagy dysfunction
neurodegeneration · completedAutophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archivedEpigenetic reprogramming in aging neurons
neurodegeneration · archivedMicroglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archivedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (30)

P2RY12 regulation of autophagy in VSMCs
exploratory · proposed · Score: 0.90Autophagy receptor identification for stress granule elimina
exploratory · proposed · Score: 0.90Trehalose-induced lysosomal changes and TFEB activation
exploratory · proposed · Score: 0.90iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · completed · Score: 0.90Trehalose-induced lysosomal membrane permeabilization and TF
exploratory · proposed · Score: 0.90

See Also (4)

ABCA7 (Redirect)
redirect · KG edge: associated_withABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: activatesABCD3 Gene
gene · KG edge: interacts_withABCG1 Gene
gene · KG edge: co_discussed

Knowledge Graph (12 edges)

autophagy regulates ferroptosis
ULK1 activates autophagy
autophagy activates bacterial_clearance
autophagy activates NRF2
autophagy treats neurodegeneration
autophagy regulates intestinal_epithelium
autophagy regulates tight_junctions
autophagy activates barrier_function
autophagy regulates intestinal_stem_cells
autophagy regulates secretory_cells

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