| Gene Symbol | EZH2 |
| Full Name | Enhancer of Zeste Homolog 2 |
| Chromosome | 7q36.1 |
| Function | H3K27me3 is the transcriptionally repressive mark that defines Polycomb-silenced chromatin. |
| Molecular Weight | 85.4 kDa |
| Amino Acids | 746 aa |
| Exons | 20 |
| Pathways | Autophagy, Circadian Rhythm, Epigenetic, Histone Modification, Inflammasome |
| UniProt ID | Q15910 |
| NCBI Gene ID | 2146 |
| Ensembl ID | ENSG00000106462 |
| OMIM | 601573 |
| GeneCards | EZH2 |
| Human Protein Atlas | EZH2 |
| Monomethylation (H3K27me1) | Often associated with gene activation |
| Associated Diseases | Alzheimer disease, Cancer, Infection, Inflammation, major depressive disorder, memory formation |
| Known Drugs/Compounds | EPZ6438, Tazemetostat |
| Interactions | AGING, AKT, AMPK, AND, App, ATG16L1 |
| SciDEX Hypotheses | EZH2 Inhibitor Therapy to Restore Neuronal Identit Stress-Responsive Epigenetic Memory (SREM) |
| KG Connections | 311 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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