concept

GEMCITABINE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GEMCITABINE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

0Hypotheses

0Analyses

15Outgoing

11Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	GEMCITABINE
Key Genes/Proteins	IDH2, DNMT3A, SIRT1, HDAC1, LRP1
Related Diseases	CANCER, TUMOR GROWTH, PANCREATIC_CANCER, APOPTOSIS, FERROPTOSIS

Wiki Pages (4)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    GEMCITABINE["GEMCITABINE"]
    GEMCITABINE -->|"targets"| Urothelial_Carcinoma["Urothelial Carcinoma"]
    GEMCITABINE -->|"inhibits"| Pancreatic_Tumor_Growth["Pancreatic Tumor Growth"]
    GEMCITABINE -->|"synergizes_with"| TUMOR_GROWTH["TUMOR GROWTH"]
    GEMCITABINE -->|"activates"| ferroptosis["ferroptosis"]
    GEMCITABINE -->|"treats"| PANCREATIC_CANCER["PANCREATIC_CANCER"]
    PRMT1_INHIBITION["PRMT1 INHIBITION"] -->|"interacts"| GEMCITABINE
    PRMT1["PRMT1"] -->|"targets"| GEMCITABINE
    Deoxycytidine_Triphosphate["Deoxycytidine Triphosphate"] -->|"interacts"| GEMCITABINE
    IDH2["IDH2"] -->|"activates"| GEMCITABINE
    FIBROBLASTS["FIBROBLASTS"] -->|"implicated in"| GEMCITABINE

Outgoing (19)

Target	Relation	Type	Str
TUMOR GROWTH	synergizes_with	phenotype	0.60
PANCREATIC_CANCER	treats	disease	0.56
APOPTOSIS	associated_with	phenotype	0.50
DNMT3A	associated_with	gene	0.50
SIRT1	associated_with	gene	0.50
HDAC1	associated_with	gene	0.50
IDH2	associated_with	gene	0.45
FERROPTOSIS	associated_with	phenotype	0.45
CANCER	associated_with	disease	0.45
LRP1	associated_with	gene	0.45
FIBROBLASTS	associated_with	cell_type	0.45
STAT3	associated_with	gene	0.45
TUMOR GROWTH	associated_with	phenotype	0.45
PANCREATIC CANCER	associated_with	disease	0.45
GLYCOLYSIS	associated_with	phenotype	0.45

Incoming (14)

Source	Relation	Type	Str
PRMT1 INHIBITION	interacts_with	entity	0.90
IDH2	activates	gene	0.65
CANCER	synergizes_with	disease	0.65
DNMT3A	activates	gene	0.65
FIBROBLASTS	implicated_in	cell_type	0.55
TUMOR GROWTH	associated_with	phenotype	0.45
PANCREATIC CANCER	associated_with	disease	0.45
DRUG RESISTANCE	associated_with	phenotype	0.45
FERROPTOSIS	associated_with	phenotype	0.45
CANCER	associated_with	disease	0.45
FIBROBLASTS	associated_with	cell_type	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GEMCITABINE

Understanding Entity Pages

Wiki Pages (4)

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