Contents

ATXN2 Gene

🧬 Gene Info

Gene Symbol	ATXN2
Aliases	Ataxin-2
Chromosome	12q24.12
Function	Translational regulation — Associates with actively translating polysomes
Molecular Weight	140 kDa
Amino Acids	318 aa
Exons	32
Pathways	Apoptosis, Autophagy
GeneCards	ATXN2
Human Protein Atlas	ATXN2
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Ataxia, dementia
Known Drugs/Compounds	Antisense Oligonucleotides, levodopa, rapamycin
Interactions	ALS, AND, ATP13A2, ATXN3, C9ORF72, DNA
SciDEX Hypotheses	Ataxin-2 Polyglutamine Expansions Hijack G3BP1 to ATXN2 Antisense Oligonucleotides Reduce Dipeptide
KG Connections	326 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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Knowledge Graph

ATXN2 associated_with CACNA1A

ATXN2 associated_with CHAT

ATXN2 associated_with FERMT2

ATXN2 associated_with OPTN

ATXN2 associated_with ABCA1

ATXN2 associated_with DPM2

ATXN2 associated_with TBK1

ATXN2 therapeutic_target C9ORF72

CHAT associated_with ATXN2

ATXN2 activates LRRK2

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