gene

ATP13A2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATP13A2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

381Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Gene profile: ATP13A2/PARK9 — lysosomal ATPase linked to Kufor-Rakeb syndrome and Parkinson's disease

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🧬 Gene Info

Gene Symbol	ATP13A2
Full Name	ATPase Cation Transporting 13A2 (PARK9)
Aliases	ATPase Cation Transporting 13A2
Chromosome	1p36.13
Protein Type	Protein
Function	is a member of the P-type ATPase family that functions as a lysosomal cation transporter, primarily pumping manganese and other cations across the lysosomal membrane[@ramirez2006].
Primary Expression	Substantia nigra, Basal ganglia, Cerebral cortex
Subcellular Localization	Lysosomes, Late endosomes
Molecular Weight	446 kDa
Amino Acids	978 aa
Pathways	Autophagy
UniProt ID	Q9BYU8
Ensembl ID	ENSG00000159363
GeneCards	ATP13A2
Human Protein Atlas	ATP13A2
Associated Diseases	ALS, AMYOTROPHIC LATERAL SCLEROSIS, Aging, Alzheimer
Interactions	VPS35, EIF4G1, PARKIN, NLRP3, FA2H, DNAJC6
KG Connections	381 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: ATP13A2 — AlphaFold Q9BYU8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    ATP13A2["ATP13A2"] -->|"associated with"| Parkinson_s_disease["Parkinson's disease"]
    ATP13A2["ATP13A2"] -->|"therapeutic target"| Ms["Ms"]
    ATP13A2["ATP13A2"] -->|"therapeutic target"| Parkinson["Parkinson"]
    ATP13A2["ATP13A2"] -->|"activates"| Parkinson["Parkinson"]
    ATP13A2["ATP13A2"] -->|"expressed in"| Parkinson["Parkinson"]
    ATP13A2["ATP13A2"] -->|"therapeutic target"| GAIN["GAIN"]
    ATP13A2["ATP13A2"] -->|"therapeutic target"| LRRK2["LRRK2"]
    ATP13A2["ATP13A2"] -->|"therapeutic target"| PRKN["PRKN"]
    ATP13A2["ATP13A2"] -->|"therapeutic target"| PINK1["PINK1"]
    ATP13A2["ATP13A2"] -->|"associated with"| LRRK2["LRRK2"]
    ATP13A2["ATP13A2"] -->|"associated with"| PINK1["PINK1"]
    ATP13A2["ATP13A2"] -->|"associated with"| PRKN["PRKN"]
    style ATP13A2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Parkinson_s_disease fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Parkinson fill:#ef5350,stroke:#333,color:#e0e0e0
    style GAIN fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style LRRK2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style PRKN fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style PINK1 fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (279)

Target	Relation	Type	Str
Polyamine Homeostasis	regulates	process	0.90
NLRP3	inhibits	protein	0.90
Mitochondrial Homeostasis	modulates	process	0.90
neurons	expressed_in	cell_type	0.90
Autophagy	involved_in	process	0.85
DNAJC6	interacts_with	gene	0.80
FBXO7	interacts_with	gene	0.80
PINK1	interacts_with	gene	0.80
PRKN	interacts_with	gene	0.80
SYNJ1	interacts_with	gene	0.80
Parkinson's disease	associated_with	disease	0.80
Parkinson's disease	causes	disease	0.80
PRKN	associated_with	gene	0.70
Lysosomal Polyamine Export	regulates	biological_process	0.70
VPS13C	interacts_with	gene	0.70
GBA1	interacts_with	gene	0.70
LRRK2	interacts_with	gene	0.70
PARK7	interacts_with	gene	0.70
SNCA	interacts_with	gene	0.70
VPS13C	associated_with	gene	0.70
neuroinflammation	associated_with	disease	0.70
neurodegeneration	causes	disease	0.70
PARKINSON	associated_with	gene	0.70
oxidative stress response	participates_in	pathway	0.70
ALS	implicated_in	disease	0.70
PARK7	associated_with	gene	0.65
SNCA	associated_with	gene	0.65
FBXO7	co_discussed	gene	0.65
SNCA	co_discussed	gene	0.65
NLRP3	co_discussed	gene	0.65
neurodegeneration	co_discussed	concept	0.65
neuroinflammation	co_discussed	concept	0.65
autophagy	co_discussed	concept	0.65
neuron	co_discussed	concept	0.65
GSK3B	co_discussed	gene	0.65
MAPT	co_discussed	gene	0.65
OPTN	co_discussed	gene	0.65
SMPD1	co_discussed	gene	0.65
SQSTM1	co_discussed	gene	0.65
Ms	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Parkinson	activates	disease	0.65
Parkinson	expressed_in	disease	0.65
Ms	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Melanoma	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65

Incoming (102)

Source	Relation	Type	Str
ABCA7	co_discussed	gene	0.65
GLIOSIS	activates	phenotype	0.65
PINK1	therapeutic_target	gene	0.60
LRRK2	therapeutic_target	gene	0.60
PRKN	therapeutic_target	gene	0.60
ATXN2	activates	gene	0.60
LRRK2	activates	gene	0.60
PRKN	expressed_in	gene	0.60
GAIN	expressed_in	gene	0.60
PINK1	expressed_in	gene	0.60
LRRK2	expressed_in	gene	0.60
SNCA	associated_with	gene	0.60
GAIN	therapeutic_target	gene	0.60
PINK1	associated_with	gene	0.60
PARK2	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
GBA	associated_with	gene	0.60
C9ORF72	regulates	gene	0.60
GAIN	regulates	gene	0.60
GBA	inhibits	gene	0.60
PARKIN	associated_with	gene	0.60
TFEB	causes	gene	0.60
C9ORF72	causes	gene	0.60
TAU	causes	gene	0.60
GAIN	causes	gene	0.60
MAPT	causes	gene	0.60
APP	causes	gene	0.60
GRN	causes	gene	0.60
APOE	causes	gene	0.60
GCASE	activates	gene	0.60
PARK7	associated_with	gene	0.60
GCH1	associated_with	gene	0.60
VPS35	associated_with	gene	0.60
GBA1	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
DNAJC13	associated_with	gene	0.60
FBXO7	associated_with	gene	0.60
VPS13C	associated_with	gene	0.60
DNAJC6	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
GFAP	associated_with	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
ALPHA-SYNUCLEIN	therapeutic_target	gene	0.60
PARKINSON'S DISEASE	expressed_in	gene	0.60
PARKINSON	expressed_in	gene	0.60
DJ-1	expressed_in	gene	0.60
GENES	associated_with	gene	0.60
DJ-1	therapeutic_target	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
ALS	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ATP13A2

Understanding Entity Pages

Summary

Wiki Pages (21)

ATP13A2 — ATPase Cation Transporting 13A2

Progressive Supranuclear Palsy (PSP)

Parkinson's Disease

Multiple System Atrophy

Alzheimer's Disease

Mitochondrial Quality Control

Synucleinopathy Mechanism

oxidative-stress-comparison

Synaptic Vesicle Trafficking in Parkinson's Disease

Neuronal Ceroid Lipofuscinosis (NCL)

Gene-Mechanism-Therapy Causal Chains

Insulin Signaling in Parkinson's Disease

ATP13A2 Lysosomal Dysfunction Pathway in Parkinson's Disease

sporadic-familial-pd-comparison

Lysosomal Dysfunction in Neurodegeneration

mitochondrial-dynamics

Endosomal Sorting Defects in Neurodegeneration

Alpha-Synuclein Propagation Mechanism

Autophagy-Lysosomal Pathway in Parkinson's Disease