| Gene Symbol | MOG |
| Full Name | Myelin Oligodendrocyte Glycoprotein |
| Chromosome | 6p22.2 |
| Function | MOG is a type I transmembrane glycoprotein with an immunoglobulin-like domain. |
| Molecular Weight | 28 kDa |
| Pathways | Complement, Oxidative Phosphorylation |
| NCBI Gene ID | 4340 |
| Ensembl ID | ENSG00000137355 |
| GeneCards | MOG |
| Human Protein Atlas | MOG |
| Myelin surface localization | MOG is located on the outer surface of the myelin sheath, making it accessible to immune cells |
| Cell adhesion | MOG participates in oligodendrocyte process extension and myelin compaction |
| Complement activation | The extracellular domain can activate the complement cascade |
| Immunomodulation | Interacts with immune cells and may regulate T cell responses |
| Axon-oligodendrocyte signaling | May participate in bidirectional communication |
| Associated Diseases | AD, Aging, Als, Autoimmune, MOGAD |
| Known Drugs/Compounds | metformin |
| Interactions | AMPK, APOPTOSIS, AQP4, ATG5, ATP, AXON |
| SciDEX Hypotheses | Oligodendrocyte White Matter Vulnerability |
| KG Connections | 277 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
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